Laboratoire de Génétique et de biologie cellulaire (LGBC)

Laboratory presentation

The main research themes developed at LGBC concern on the one hand the modalities and regulation of cell death processes, in particular at the mitochondrial level, and on the other hand, the compensatory mechanisms involved in the maintenance of tissue homeostasis at following stress involving the mitochondria or endoplasmic reticulum. For this, we use cellular models of mammals and Drosophila.

At the same time, we are carrying out collaborative projects which notably use models mimicking pathologies in Drosophila.

The 20 latest publications

Title Authors Publication date Source
A High-Throughput Search for SFXN1 Physical Partners Led to the Identification of ATAD3, HSD10 and TIM50 Nesrine Tifoun, Mourad Bekhouche, José M. De las Heras, Arnaud Guillaume, Sylvina Bouleau, Isabelle Guénal, Bernard Mignotte, Nathalie Le Floch 09/01/22 Biology
Apoptosis quantification in tissue: Development of a semi-automatic protocol and assessment of critical steps of image processing Juliette de Noiron, Marion Hoareau, Jessie Colin, Isabelle Guénal 10/01/21 Biomolecules
Lessons on SpA pathogenesis from animal models Aurore Rincheval-Arnold, Sébastien Gaumer, Isabelle Guénal 04/01/21 Seminars in Immunopathology
HLA-B27 alters BMP/TGFβ signalling in Drosophila, revealing putative pathogenic mechanism for spondyloarthritis Benjamin Grandon, Aurore Rincheval-Arnold, Jean Marc Corsi, Erwann Prevost, Delphine Roche, Isabelle Guénal, Sébastien Gaumer 12/01/19 Annals of the Rheumatic Diseases
Investigating the effects of different natural molecules on the structure and oligomerization propensity of hen egg-white lysozyme Ali Chaari 08/01/19 International Journal of Biological Macromolecules
The endoplasmic reticulum unfolded protein response varies depending on the affected region of the tissue but independently from the source of stress Jessica Perochon, Benjamin Grandon, Delphine Roche, Christine Wintz, Yohan Demay, Bernard Mignotte, Sébastien Szuplewski, Sébastien Gaumer 07/01/19 Cell Stress and Chaperones
High-resolution transcription maps reveal the widespread impact of roadblock termination in yeast Jessie Colin 02/15/18 EMBO Journal
FGF1 induces resistance to chemotherapy in ovarian granulosa tumor cells through regulation of p53 mitochondrial localization Sevasti Manousakidi, Arnaud Guillaume, Caroline Pirou, Sylvina Bouleau, Bernard Mignotte, Flore Renaud, Nathalie Le Floch 02/01/18 Oncogenesis
Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity Delphine Sitterlin 10/01/17 Journal of Hepatology
FGF1 protects neuroblastoma SH-SY5Y cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation Caroline Pirou, Fatemeh Montazer-Torbati, Nadège Jah, Elisabeth Delmas, Christelle Lasbleiz, Bernard Mignotte, Flore Renaud 08/01/17 Cell Death and Disease
Clone war: tumour-suppressive cell competition Bernard Mignotte 06/01/17 Medecine/sciences
Evolutionary conservation of Notch signaling inhibition by TMEM131L overexpression Sébastien Szuplewski, Bernard Mignotte, Isabelle Guénal 05/13/17 Biochemical and Biophysical Research Communications
The comeback of mitochondria in Drosophila apoptosis Amandine Clavier, Aurore Rincheval-Arnold, Bernard Mignotte, Isabelle Guénal 05/01/16 Medecine/sciences
Apoptosis in Drosophila: Which role for mitochondria? Amandine Clavier, Aurore Rincheval-Arnold, Jessie Colin, Bernard Mignotte, Isabelle Guénal 03/01/16 Apoptosis : an international journal on programmed cell death
FGF1 C-terminal domain and phosphorylation regulate intracrine FGF1 signaling for its neurotrophic and anti-apoptotic activities Elisabeth Delmas, Nadège Jah, Caroline Pirou, Sylvina Bouleau, Nathalie Le Floch, J. L. Vayssière, Bernard Mignotte, Flore Renaud 02/04/16 Cell Death and Disease
Two different specific JNK activators are required to trigger apoptosis or compensatory proliferation in response to Rbf1 in Drosophila Amandine Clavier, Aurore Rincheval-Arnold, Adrienne Baillet, Bernard Mignotte, Isabelle Guénal 01/17/16 Cell Cycle
A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1 Frédéric Canal 12/29/15 BMC Cancer
Insights into kinetics of agitation-induced aggregation of hen lysozyme under heat and acidic conditions from various spectroscopic methods Ali Chaari 11/01/15 PLoS ONE
Quantification of Ataxin-3 and Ataxin-7 aggregates formed in vivo in Drosophila reveals a threshold of aggregated polyglutamine proteins associated with cellular toxicity Gérald Vinatier, Jean Marc Corsi, Bernard Mignotte, Sébastien Gaumer 09/04/15 Biochemical and Biophysical Research Communications
Inactivation of p53 is sufficient to induce development of pulmonary hypertension in rats Vincent Rincheval, Bernard Mignotte 06/29/15 PLoS ONE

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)