Laboratoire de Génétique et de biologie cellulaire (LGBC)

Présentation du laboratoire

Les principaux thèmes de recherche développés au LGBC concernent d'une part les modalités et la régulation des processus de mort cellulaire, en particulier au niveau mitochondrial, et d'autre part, les mécanismes compensatoires impliqués dans le maintien de l'homéostasie tissulaire à la suite de stress impliquant la mitochondrie ou le réticulum endoplasmique. Pour cela, nous utilisons des modèles cellulaires de mammifères et les drosophiles..

En parallèle, nous menons des projets en collaboration qui utilisent notamment des modèles mimant des pathologies chez la drosophile.

Les 20 dernières publications

Titre Auteurs Date de publication Source
A High-Throughput Search for SFXN1 Physical Partners Led to the Identification of ATAD3, HSD10 and TIM50 Nesrine Tifoun, Mourad Bekhouche, José M. De las Heras, Arnaud Guillaume, Sylvina Bouleau, Isabelle Guénal, Bernard Mignotte, Nathalie Le Floch 01/09/2022 Biology
Apoptosis quantification in tissue: Development of a semi-automatic protocol and assessment of critical steps of image processing Juliette de Noiron, Marion Hoareau, Jessie Colin, Isabelle Guénal 01/10/2021 Biomolecules
Lessons on SpA pathogenesis from animal models Aurore Rincheval-Arnold, Sébastien Gaumer, Isabelle Guénal 01/04/2021 Seminars in Immunopathology
HLA-B27 alters BMP/TGFβ signalling in Drosophila, revealing putative pathogenic mechanism for spondyloarthritis Benjamin Grandon, Aurore Rincheval-Arnold, Jean Marc Corsi, Erwann Prevost, Delphine Roche, Isabelle Guénal, Sébastien Gaumer 01/12/2019 Annals of the Rheumatic Diseases
Investigating the effects of different natural molecules on the structure and oligomerization propensity of hen egg-white lysozyme Ali Chaari 01/08/2019 International Journal of Biological Macromolecules
The endoplasmic reticulum unfolded protein response varies depending on the affected region of the tissue but independently from the source of stress Jessica Perochon, Benjamin Grandon, Delphine Roche, Christine Wintz, Yohan Demay, Bernard Mignotte, Sébastien Szuplewski, Sébastien Gaumer 01/07/2019 Cell Stress and Chaperones
High-resolution transcription maps reveal the widespread impact of roadblock termination in yeast Jessie Colin 15/02/2018 EMBO Journal
FGF1 induces resistance to chemotherapy in ovarian granulosa tumor cells through regulation of p53 mitochondrial localization Sevasti Manousakidi, Arnaud Guillaume, Caroline Pirou, Sylvina Bouleau, Bernard Mignotte, Flore Renaud, Nathalie Le Floch 01/02/2018 Oncogenesis
Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity Delphine Sitterlin 01/10/2017 Journal of Hepatology
FGF1 protects neuroblastoma SH-SY5Y cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation Caroline Pirou, Fatemeh Montazer-Torbati, Nadège Jah, Elisabeth Delmas, Christelle Lasbleiz, Bernard Mignotte, Flore Renaud 01/08/2017 Cell Death and Disease
Clone war: tumour-suppressive cell competition Bernard Mignotte 01/06/2017 Medecine/sciences
Evolutionary conservation of Notch signaling inhibition by TMEM131L overexpression Sébastien Szuplewski, Bernard Mignotte, Isabelle Guénal 13/05/2017 Biochemical and Biophysical Research Communications
The comeback of mitochondria in Drosophila apoptosis Amandine Clavier, Aurore Rincheval-Arnold, Bernard Mignotte, Isabelle Guénal 01/05/2016 Medecine/sciences
Apoptosis in Drosophila: Which role for mitochondria? Amandine Clavier, Aurore Rincheval-Arnold, Jessie Colin, Bernard Mignotte, Isabelle Guénal 01/03/2016 Apoptosis : an international journal on programmed cell death
FGF1 C-terminal domain and phosphorylation regulate intracrine FGF1 signaling for its neurotrophic and anti-apoptotic activities Elisabeth Delmas, Nadège Jah, Caroline Pirou, Sylvina Bouleau, Nathalie Le Floch, J. L. Vayssière, Bernard Mignotte, Flore Renaud 04/02/2016 Cell Death and Disease
Two different specific JNK activators are required to trigger apoptosis or compensatory proliferation in response to Rbf1 in Drosophila Amandine Clavier, Aurore Rincheval-Arnold, Adrienne Baillet, Bernard Mignotte, Isabelle Guénal 17/01/2016 Cell Cycle
A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1 Frédéric Canal 29/12/2015 BMC Cancer
Insights into kinetics of agitation-induced aggregation of hen lysozyme under heat and acidic conditions from various spectroscopic methods Ali Chaari 01/11/2015 PLoS ONE
Quantification of Ataxin-3 and Ataxin-7 aggregates formed in vivo in Drosophila reveals a threshold of aggregated polyglutamine proteins associated with cellular toxicity Gérald Vinatier, Jean Marc Corsi, Bernard Mignotte, Sébastien Gaumer 04/09/2015 Biochemical and Biophysical Research Communications
Inactivation of p53 is sufficient to induce development of pulmonary hypertension in rats Vincent Rincheval, Bernard Mignotte 29/06/2015 PLoS ONE

Nombre de publications du laboratoire par domaine scientifique (2016-2021)

Chaque publication du laboratoire peut être rangée dans une ou plusieurs disciplines scientifiques : la figure ci-dessus présente le nombre de publications du laboratoire pour chaque discipline de la classification ASJC (Elsevier)