M2 Development of Drugs and Health Products

Co coordinator virology: Pr A Esclatine co coordinator bacteriology: Pr I Kansau co coordinator parasitology: Pr P Loiseau Dr D. Bonte, Dr T. Candela, Pr A. Esclatine, Pr C. Janoir, Pr I. Kansau, Dr P. Loiseau, Dr M. Lussignol, Dr J.-C. Marvaud, Dr N. Nicolaos-Bourgeois, and Dr S. Pomel.

A. Virology Knowledge on commercialized antiviral molecules and vaccinal approaches Update on treatment strategies for HIV, hepatitis viruses, herpesvirus, influenza viruses, and arboviruses Viral resistance Tutorials: publication analyses B. Bacteriology - Bacterial virulence factors and host response The Bacillus and Pneumococci capsules, botulinic and tetanic toxins, vaccinal approaches The intracellular bacteria: Mycobacterium Salmonella Listeria Shigella spp. - Bacterial resistance to antibiotics Gene support and gene transfer - The human microbiota The intestinal, cutaneous and other microbiota Study tools, functional metagenomic Tutorials: publication analyses C. Parasitology and medical mycology - Mechanisms of action of antileishmanial agents and drug resistance - Research of antileishmanials based on parasite targets Tutorials: Analysing literature and building projects on drug resistance and new drugs, workshop.

The courses, seminars and training in virology, bacteriology, parasitology and medical mycology aim to present the current and up-to-date strategies developed for the control of viruses, bacteria, parasites and fungi, mainly focusing on the design of drugs and the approaches to decipher their mechanisms of action and drug resistance. The challenges to face emergent infectious diseases will be also addressed.
Tutorials will be devoted to the presentation of articles by students and propositions of scientific projects to go further including innovative and realistic developments.
Teaching will allow students to understand the strategies developed for the control of infectious diseases and drug resistance, including the research of new drugs and the development of strategies to overcome the current drug resistance issues.
Classes and seminars will allow the students to be aware of the new challenges due to emergent diseases.
Critical analysis of literature documents: courses will be completed by the reading of scientific papers, followed by a large global discussion.
Relational, collaborative, and communication skills (written and oral): publication analyses in virology and bacteriology, workshop in parasitology and medical mycology organised with a round table to facilitate exchanges on different projects.

Being registered to the M2 master's degree.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

Pr S. Ongeri, Pr D. David, invited clinicians.

Courses and group works.

Up-to-date knowledge on therapies for neurodegenerative and psychiatric diseases:
- Advanced therapies for Multiple Sclerosis, Parkinson's and Alzheimer's Diseases
- Advanced therapies against depression, anxiety and psychiatric disorders.

Being registered in the M2 master's degree.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

Co coordinator: Pr C. Poüs Dr A. Baillet, Dr B. Benoit, Dr N Chaput, Dr N. Charef, Dr S Edhery, Dr J Hamelin, Dr E Morel, Dr K Olausssen, Dr A. Pilon, and Pr C. Poüs.

The following program will be presented to the students: - Updates in tumor characterization and theranostic - Canonical and advanced cancer treatment (ie: targeted doxorubicin, I-Bet) - Detailed side effects of cancer treatment, resistance and current protection in clinics (chemotherapies, radiotherapies, targeted therapies, combined therapies) - Radiotherapy: low doses, flash radiation delivery, heavy ion radiotherapy.

This teaching unit follows the TU Oncology in M1 and propose advanced knowledge in cancer therapy in 4 different and complementary ways: diagnosis, treatments, side effects and focus on new technics (radiotherapy, immunomodulation,...).
Students will acquire:
- Advanced knowledge of the general principles and parameters analized in oncology
- Critical analysis of bibliographical experimental data related to cancer
- Understanding of the diagnosis and therapeutic strategies currently used in cancer
- Access to the basic knowledge necessary to work efficiently in the field of cardio-oncology
- Efficient interactions with healthcare professionals in the field of oncology.

Being registered to the M2 master's degree D2HP.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

Co-coordinator : Dr E Bianchini Dr L. de Chaisemartin, Dr F. Saller, Pr M. Vasse, Pr N. Chaput, Pr S Chollet-Martin.

A- Immunology (10h) -Allergenic immunotherapy, immunosuppressive drugs, cancer immunotherapy, auto-immune disease immunotherapy.

B-Hematology (6h courses, 4h tutorials) - coagulation disorders associated with inflammation : coagulation and vascular dysfunction, associated septic/ sterile inflammation, - NETosis and immunothrombosis: NETs formation, structure and function, immunothrombosis. tutorial : writting a project to apply for a grant in field of hemostasis.

Up-to-date knowledge on immune intervention strategies, hemostasis and inflammation :
Students will be able to discss current therapeutic approaches to immune and hematologic diseases. Students will be able to write a grant application in the field of hemostasis.

To be enrolled in the M2 "Development of Drugs and Health Products".

Septembre - Octobre - Novembre - Décembre.

CHATENAY

Dr J.P. Benitah, Dr M.-C. Chaumais, Pr D. David, Dr S. Edhery, Dr R. Fischmeister, Pr A. Gardier, Dr A.-M. Gomez, Pr M. Humbert, Dr C. Lemaire, Dr J. Leroy, Dr B. Manoury, Pr J.J. Mercadier, Dr M. Merickskay, Dr D. Mika, Dr E. Morel, Dr L Pereira, Dr J Piquereau, Pr V. Vecksler, Dr R. Ventura-Clapier.

Students will have access to courses and seminars of specialists in the following research fields : - Clinical pharmacy, heart and cardiovascular system - Lung and PAHT - Neuropharmacology - Advanced treatments in cardiovascular diseases - Reduced and preserved ejection fraction in heart failure - Future treatments in cardio-oncology.

This TU is in the continuity of the M1 courses focusing on the main major functions of human physiology. Students will thus extend and deepen their knowledge of main function dysregulations seen in M1 and the associated physiopathology, diagnosis, current and future treatments.
- Student’s knowledge will be improved on classical therapies and molecular signaling involved in each of these major physiopathologies.
- Students will gain knowledge of the models used in pathology in order to handle PK/PD analysis, perform quantitative and qualitative analyses (clinical parameters, biomarkers) and test future pharmaceutical treatments.
- Students will acquire critical analysis of bibliographical experimental data related to physiopathology, organ dysfunction, and signaling pathways.

Being registered in the master D2HP.

- Robbins and Cotran, Pathologic Basis of Disease, 9th Edition, Elsevier 2019 - Michael Zigmond Joseph Coyle Lewis Rowland, Neurobiology of Brain Disorders, 1st Edition, Academic Press 2015 - Neil Herring, David J. Paterson, Levick's Introduction to Cardi.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

Co coordinator: Dr E Morel Pr N. Chaput, Dr D. Bonte, Dr F Fay, Dr E. Morel, and Dr I. Turbica.

A. Gene and cell therapies (14h) Applied molecular biology, current treatments in gene and cell therapies, upscale processes in pharmaceutics, development of a candidate drug from bench to bedside, research options in gene therapy and cell therapies B. Upstream and downstream biomedicine processes (13h) Bioprocesses, biosimilars, bioproduction II, vectorisation II C. Advanced biotechnology II (13h) New technics in biotechnology, new targets in therapy II (identification and validation of new molecules), new targets in therapy II (preclinical and clinical steps), new medicine (conception and development), medicinal products derived from human blood and plasma.

This teaching unit is the continuity of the Biotechnology I from the M1. Students will obtained an in depth knowledge in biotechnology with access to more complex and advanced notions in the field of biotechnologies under the form of research seminar:
- Gene and cell therapies
- Upstream and downstream biomedicine processes
- Targets in therapies (identification, conception, development, and clinics).

Being registered in the M2 master's degree D2HP.

Daan J. A. Crommelin, Robert D. Sindelar, Bernd Meibohm. Pharmaceutical Biotechnology: Fundamentals and Applications, Springer, 5th ed. 2019.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

K. Bouchemal V. Faivre H. Hillaireau F.-X. Legrand A. Makky J.-P. Michel S. Mura V. Rosilio M. Varna J. Vergnaud + Invited lecturers from companies, CNRS and foreign universities.

Theory, tutorials, project.

Advanced teaching unit on the innovative formulation strategies for the delivery of small chemical molecules, peptides, proteins and siRNA. Issues related to the formulation of biomolecules. Nanotoxicity.

Programme:
A.Advanced formulation strategies and innovative drug delivery systems (self-assembled systems, lipid systems, nanoparticles)
B.In vitro and in vivo evaluation of targeted and theranostic systems
C.Case study.

To be enrolled in the M1 Development of drugs and health products.

- C. Vauthier, G. Ponchel: Polymer nanoparticles for nanomedicines, 2017 - DIRECTIVE 2010/63/EU - 22 September 2010 on the protection of animals used for scientific purposes - Décret no 2013-118 du 1er février 2013 relatif à la protection des animaux util.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

M. Beniddir E. Drège L. Evanno N. Gigant A. Hamze D. Joseph J. Kaffy P. Le Pogam-Alluard T. Milcent S. Ongeri E. Poupon.

Theory.

Objectives: Covers the most important current synthetic approaches within the field of organic synthesis, including catalysis and asymmetric synthesis. Emphasizes organic chemistry to biomimetic natural product synthesis. Provides the tools necessary for deducing the three-dimensional structure of organic compounds through a combination of advanced spectroscopy techniques.

Content:
A.Advanced synthetic approaches for the preparation of natural and synthetic drugs
A.1.Catalytic C-C bond formation in total synthesis of natural products and drugs
A.2.Advanced stereochemical aspects in the synthesis of natural and synthetic drugs
A.3.C-X bond formation applied to the synthesis of therapeutic peptides and pharmaceuticals
B.Biomimetic natural product synthesis
C.Advanced structural elucidation of natural and synthetic drugs.

To be enrolled in the M2 Development of Drugs and Health Products.

- Organic Chemistry by J. Clayden, N. Greeves and S. Warren, 2012, OUP Oxford - Applications of Transition Metal Catalysis in Drug Discovery and Development: An Industrial Perspective by M. L. Crawley and B. M. Trost, 2012, John Wiley & Sons, Inc. - Stere.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

S. Karolak A. Kasselouri R. Michael-Jubeli S. Tfaili A. Tfayli T. Duc Mai L. Oziol.

The students choose one of the two paths: Analytical sciences or Environment 2

In the teaching unit on Analytical Sciences, they participate to small group projects in research laboratories/ platforms with the appropriate equipment. Collaboration with specialized teams.

The teaching unit on Environment 2 consists in small group bibliographical projects on case studies.

The students choose either the programme A or B.

A: Practical immersion of students in laboratory work by realization of an integrated project in analytical sciences.
B: Case study on an environmental issue related to drugs, endocrine disruptors and nanotechnologies.

A.Analytical sciences and data evaluation
Integrated project for products detection
Compact and inexpensive analytical instrumentation/device conception for quick analyses of counterfeit drugs/doping/ illegal drugs; Molecular screening (omic) of diseases; Biomolecule analysis and drug detection and follow-up; Analytical chemistry for dermatology and cosmetic science; Chemometrics for process analytical technology (PAT); Integrated project on the analysis of a finished product: Raw material analysis, final product analysis, etc.

B.Environmental issues
Issues specific to new drugs, nanoparticles or other environmental organic pollutant. Analysis or risk assessment, according to a therapeutic class.

To be enrolled in the M2 Development of Drugs and Health Products.

- Introduction to Modern Liquid Chromatography, 3rd Edition; Lloyd R. Snyder, et al.; Wiley, 2011

- Principles of Instrumental Analysis; Douglas A. Skoog, F. James Holler, Stanley R. Crouch; Cengage Learning, 2017.

- J. Kim H. Esbensen, et al. (2018).

Septembre - Octobre - Novembre - Décembre.

CHATENAY

T. Ha-Duong.

Theory, practical works, project.

In this teaching unit, students are asked to choose one or the other of the two options proposed below.

A.Biomolecular modeling
-Biomolecular forces fields: From atoms to coarse grains
-Simulation techniques (molecular docking, molecular dynamics...)
-Structure and dynamics of biomolecules
-Complexes and aggregates of biomolecules
-Biomolecule - small compound interactions

B.Bioinformatics
-Molecular databases and chemical libraries
-Structural bioinformatics
-QSAR
-Pharmacophore screening
-ADMET prediction.

Registration to the master D2HP.

- Leach A., Molecular Modelling: Principles and Applications, 2nd Edition, 2001 - Höltje H-D., Sippl W., Rognan D., Folkers G., Molecular Modeling, Basic Principles and Applications, 2008.

Septembre - Octobre - Novembre.

CHATENAY

A. Gardier, S. Kerdine-Römer, Marc Pallardy, Armelle Biola-Vidamment, Kevin Hardonnière, Jean-Philippe Guilloux, Laurent Tritschler, Boris Manoury, Denis David, Véronique Leblais.

Courses, Scenario and personal project work.

The program conveys comprehensive knowledge about toxicants including their impact on living organisms. Students will gain a deep understanding in general toxicology and organ toxicology. They will understand the close links between pharmacological activity and the toxicity of health products. Students will also acquire substantial knowledge on national and international legislative and regulatory processes.
Pharmacology:
- Concepts and strategies used in research as well as the complementary experimental in vitro and in vivo methodologies: in vitro cellular models, in vivo models (neurochemistry and behavioral tests) of a pathology.
- Designing experimental protocols appropriate for drug research and development.
- Analyzis of the scientific literature and results.
Toxicology:
- Mechanisms of toxicity: cellular toxicology, oxidative stress, inflammatory mechanisms, molecular bases of immunotoxicity, hepatotoxicity and genotoxicity
- Target organ toxicology: Liver, kidney, lungs, blood and heart, and toxicants.
- Regulatory toxicity testing
- Project work: a 20-page report on the themes addressed.

To be enrolled in the M2 "Development of Drugs and Health Products".

- Casarett & Doull’s Toxicology: The Basic Science of Poisons (Curtis D. Klassen) - Principles and Methods of Toxicology ( A. Wallace Hayes, Claire L. Kruger) - The Pharmacological Basis of Therapeutics (Goodman & Gilman, Ed. McGraw-Hill) 2017.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

Co coordinator: Dr D Bonte Dr E Bianchini, Dr D Bonte, Dr F Fay, Pr P Gaussem, Dr M Lussignol, Dr E Morel, and Pr V Rosilio.

This research unit is a scientific and tutored preparation to the M2 lab internship with the aim to prepare the students to their future career as a researcher: - Appropriation of the bibliographical background of their research topic - Writing of a well-known European grant on their project with PI interaction - Defense of their project in front of a multidisciplinary jury composed of academic and industrials The frame is the following: 1 introductory course 4 appointments to work on the slides and talks of the students with the tutors 1 tutored session to help on the grant writing 1 session in front of the multidisciplinary jury for the final defense, jury composed of tutors and other members from various fields.

Students will be trained to the researcher's career with the objectives of:
- handling the literature data linked to their next research topic/M2 lab internship
- improving communication skills and team communication due to early and strong interaction with team and supervisor of the lab internship
- building and managing a research project with the overview starting from the literature, experimental aspects and strategic orientation in agreement with their lab supervisor
- managing networks, human resources, materials and instrumentation to fulfill the final research aim
- planning ahead their research project: building Gantt and PERT diagrams
- performing financial planning and budget estimation
- seeking financial funding with application to the most classical European grants
- improving oral and writing communication by a defense and Grant writing before they start their lab internship.

Being registered to the M2 master's degree D2HP.

Octobre - Novembre - Décembre.

CHATENAY

C. Aymes-Chodur J.P. Michel V. Rosilio J. Vergnaud F. Agnely N. Huang + invited professionals from the industry.

Theory and project.

Overview of materials used for biomedical applications (tissue engineering, 3D-printed systems, medical devices, etc.) Methods of characterization of biomaterials. Biological interactions between biomaterials and living tissues.

To be enrolled in the M2 Development of Drugs and Health Products.

- Biomaterials in Clinical Practice - Advances in Clinical Research and Medical Devices, Springer International Publishing. Zivic, F. et al. (2018) - Biopolymers and Biomaterials, Apple Academic Press. Padinjakkara A. et al. (2018) - Biomaterials Science.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

Co coordinator: Dr E Morel Dr D Bonte, Dr C Deloménie, Dr F Fay, Dr M Lussignol, Dr E Morel, and Dr I Turbica.

This teaching unit is entirely composed of practical courses: The subject and objectives of the practical works will be explained to the students so that they can work in half-group on the project and propose protocols, experiments to answer the asked scientific questions. They will present their experimental strategies orally to the practical course stakeholders and will be corrected Then the experimentation part takes place on 5 days with : - measure of cell (CHO) viability and plating in appropriate density - infection with adenovirus serotype 5, AAV serotype 2 of CHO cells with dose response MOI determined by the students in regard to the literature data - transfection of the same cell type (CHO) with jet PEI and lipofectamine protocol - titration of a virus - Gene transfer wil be evaluated by cell GFP expression and morphological cell structure by F actin staining will be evaluated The students present their results orally at the end of the practical works.

This teaching unit includes practical works on the application of knowledge acquired in the different theoretical courses received in gene therapy. Students will apply viral and non viral gene transfer methods used in biotechnology in L2 laboratory aseptic conditions that they could encounter in their professional life. Classical read out of transfected/infected cell morphology will be evaluated in order to find the fit between expression efficiency and cell model alteration.

Being registered in the M2 degree's master D2HP.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

Co coordinator: Dr E Morel Dr D Bonte, Dr C Deloménie, Dr F Fay, Dr M Lussignol, Dr E Morel, and Dr I Turbica.

During the practical courses, students will perform: Production and quality control of murine erythropoietin (EPO) Biological part - Control of transgene integration in host genome cell - Control of transfered gene expression - EPO purification Used technics: mRNA and DNA extraction, RT-qPCR, DEAE chromatography Analytical part Quality control of purified and pharmaceutical EPO Used technics: SDS-PAGE and WB, ELISA

Oral presentations will be given by the students in the frame of prospective works for practical works preparation and at the end of the experimentation as a conclusion.

This teaching unit includes practical works on the application of the knowledge acquired in the different theoretical courses done in bioproduction, quality control and analytical chemistry. Students will acquire a practical mastery of the production and purification techniques of a therapeutic protein (EPO) and analytical techniques for the quality control of a pharmaceutical formulation.

Being registered in the M2 master's degree D2HP.

Monograph Erythropoietin Concentrated Solution, European Pharmacopoeia 9th Edition, 1/2019: 1316.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

A. Tfayli (co-coordinator of the teaching unit) D. Mai C. Smadja S. Tfaili T. Tran.

Theory and practical works.

Emerging analytical approaches with highlights on miniaturization, simple and fast operation as well as high detection performance :
Biosensors and magneto-immunoassays: electrokinetic and microfluidic systems (lab-on-chip, droplet systems, capillary electrophoresis); enrichment and separation in microchips (monolithic supports, solid support extraction, electrokinetic separation)
Spectral techniques : Raman derived techniques, SERS, CARS, SRS ; Terahertz ; Handheld spectroscopies, application domains, performance and limitations.

To be enrolled in the M2 Development of Drugs and Health Products.

- Frank S. Parker (1983) Applications of Infrared, Raman, and Resonance Raman Spectroscopy in Biochemistry, Plenum Press, New York and London 1983 (ISBN-13: 978-0306412066). - Luka et al. Microfluidics integrated biosensors: A leading technology towards l.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

G. Bernadat P. Chaminade H. Diarra A. Kasselouri S. Tfaili A. Tfayli.

Theory and practical works.

General concepts concerning experimental approach, data processing and chemometrics:
1. Statistics and open source software accessible to research and industrial laboratories: Statistical and mathematical tools for the exploration of experimental data
2. Generate data: experimental approach, experimental designs and available tools: Introduction to experimental designs and their application
3. Make the data talk: chemometrics, multivariate methods applied to industrial and research issues:
a. Introduction to chemometrics
b. Example of a descriptive multivariate method: Principal Component Analysis
c. Example of an Explicit Multivariate Method: Partial Least Squares Regression

4. Organizing Data: Databases and Data Management:
a. Different types of databases: theory and practice
b. Virtual research environment (VRE).

To be enrolled in the M2 Development of Drugs and Health Products.

- J. Kim H. Esbensen, Brad Swarbrick, Frank Westad, Pat Whitcomb, Mark Anderson (2018). Multivariate data analysis: an introduction to multivariate analysis, process analytical technology and quality by design. CAMO Software AS; 6th Edition edition (ISBN:.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

Co coordinator: Dr M Lussignol Dr M.-F. Bernet-Camard, Dr D. Bonte, Dr M.-C. Chaumais, Pr A. Esclatine, Dr M. Lussignol, Dr V. Marin-Esteban, and Dr S. Pomel.

Class: Generalities about immunosuppression and infections (2h) A- Causes of immunosuppression Pretransplantation check-up: HLA compatibility (1h of class / tutorials) Immunosuppressive therapy (2h of class / tutorials) Infection by human immunodeficiency virus and antiretroviral treatment, different clinical cases to be treated (1h30 of class/tutorials + 1h30 of tutorials (clinical cases)) B- Infections and immunosuppression Adenovirus and immunosuppression, comparison of 2 diagnostic methods: viral titration and qPCR (5h of practical works + 2h of result analysis and discussion) Syphilis - Bacterial infections and immunosuppression (2h of tutorials) Parasite infections and immunosuppression (2h of tutorials).

The theoretical part of this unit will give students an update about immunocompromised patients. Two causes of immunosuppression will be described: transplantation and human immunodeficiency virus infection. The management of those patients will be addressed. The main infectious risks for immunocompromised patients will be treated under tutorials, mainly working on clinical cases.
Immunocompromised patients are at higher risks of infections, so examples of infections linked to immunosuppression will be given. In virology, the example of the adenovirus will be exposed. This virus can be easily diagnosed in patients, thus, the practical part will permit the students to manipulate and master two classical diagnostic methods of the adenovirus infection: viral titration and qPCR. The syphilis and other bacteria infections will be presented, same for parasite infections during immunosuppression.
Students should acquire the theoretical part concerning the immunocompromised status of the patients (causes, treatment and infectious risks)
Student should be able to manipulate viruses in aseptic conditions
Students should be able to adapt properly protocols
Critical analysis of their experimental results
Critical analysis of literature documents
Relational, collaborative, and communication skills (oral and written).

Being registered to the M2 master's degree D2HP.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

Caroline MASCRET Sylvain FORGET (Blue Dil).

Theory and Project.

Business model
Business plan
Budget management for marketers
The art of creating smart goals
Interactions with HCPs
Targeting and segmenting a market
Interaction of a Marketing department with other parts of a pharma organization.

To be enrolled in the M2 Development of Drugs and Health Products.

Octobre - Novembre - Décembre.

CHATENAY

H. Hillaireau J. Vergnaud.

Theory and project.

Preparation and characterization of basic nanosystems (liposomes, nanoparticles).

To be enrolled in the M2 Development of Drugs and Health Products.

- C. Vauthier & G. Ponchel: Polymer nanoparticles for nanomedicines, 2017 - L. Hovgaard, S. Frokjaer, M. van de Weert, Pharmaceutical Formulation, development of peptide and proteins, 2012.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

M. Beniddir P. Champy L. Evanno P. Le Pogam-Alluard A. Maciuk E. Poupon.

Tutorials.

Objective: Understanding the logic underlying chemodiversity of specialized metabolites in Nature. Being able to choose specific analytical and spectroscopic tools and approaches in the fields of dereplication and structural elucidation.

Content:
Diversity of natural products and of their biosynthetic pathways
Chemotaxonomy and structural selection in Nature
Specific analytical tools (in line tools / spectroscopic tools / anticipation tools).

Registration to the master D2HP.

Septembre - Octobre - Novembre - Décembre.

CHATENAY

Dr M. Braibant (Tour University), Dr M-L Gougeon (pasteur institute), Pr C. Janoir, (Paris Saclay), Dr N. Naffakh (Pasteur Insitute), and Dr S. Péchiné (Paris Saclay).

Courses: 10h Introduction to vaccinology Immune response to vaccines Vaccine against Streptococcus pneumoniae Vaccine development against HIV Vaccine development against influenza

Case study: 4 students per group, 10h Oral presentations based on article analysis on new vaccine development or efficacy improvement of existing vaccines.

The objective of this OTU is to sensibilize students to the field of vaccinology. Several recognized specialists will perform courses for the M2 students covering basic knowledge, up-to-date treatments and vaccines currently in development.

Being registered to the M2 master's degree.

Innovation in Vaccinology from design, through to delivery and testing, Selene Baschieri, Springer 2012.

Octobre - Novembre - Décembre.

CHATENAY

Co coordinator: Dr E. Morel Dr D Bonte Prof. V. Rosilio Prof. I. Kansau.

Cultural activities to promote interactions between students from different cultures.
Introduction to French culture
Team-building activities
Acclimation period.

Octobre - Novembre - Décembre.

CHATENAY

Co coordinators: Dr D Bonte, Dr E Morel, and Pr V Rosilio.

The lab internship must last 6 months under he direction of a research supervisor. The research work will be the subject of a written report and an oral defense in the frame of the symposium. The M2 communication will be evaluated by a multidisciplinary jury as part of their grade.

The aim is to complete classical scholar education by a training by research. Students will have to find and perform a lab internship for 6 months. Research subjects selected by the students will be validated by D2HP organizing committee.
The M2 students will present their final defense during the symposium organized by the M1 students.

Being registered to the M2 master's degree D2HP.

Janvier - Février - Mars - Avril - Mai - Juin - Juillet.

CHATENAY