Signalisation et physiopathologie cardiovasculaire (CARPAT)

Laboratory presentation

The SPC revolves around three teams developing complementary themes on animal and cell models to study the mechanisms involved in cardiac function through membrane receptors, ion channels, cyclic nucleotides, energy metabolism, calcium, and intracellular compartments. The unit aims to elucidate new pathophysiological mechanisms and identify new therapeutic targets in the treatment of heart failure and arrhythmias. It is in charge of innovative projects within the LabEx LERMIT in partnership with other laboratories of the IPSIT.

The 12 latest publications

Title Authors Publication date Source
Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice Nada J. Habeichi, Mathias Mericskay, Fouad A. Zouein 01/01/23 Clinical Science
Identification of Cx43 variants predisposing to ventricular fibrillation in the acute phase of ST-elevation myocardial infarction Rosa Doñate Puertas 01/01/23 Europace
Machine learning-based scoring system to predict in-hospital outcomes in patients hospitalized with COVID-19 Delphine Mika 12/01/22 Archives of Cardiovascular Diseases
Impacts of a high-fat diet on the metabolic profile and the phenotype of atrial myocardium in mice Marie Lhomme, Mathias Mericskay 11/01/22 Cardiovascular Research
Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension Jessica Sabourin, Jean Pierre Benitah 10/14/22 Circulation Research
Housekeeping Proteins Exhibit a High Level of Expression Variability Within Control Group and Between Ischemic Human Heart Biopsies Anne Sophie Colombe, Pascale Gerbaud, Jean Pierre Benitah, Guillaume Pidoux 09/20/22 Journal of the American Heart Association
Uptake-leak balance of SR Ca<sup>2+</sup> determines arrhythmogenic potential of RyR2<sup>R420Q+/−</sup> cardiomyocytes Pascale Gerbaud, Ana Maria Gómez 09/01/22 Journal of Molecular and Cellular Cardiology
Genomic, Proteomic, and Metabolic Comparisons of Small Animal Models of Heart Failure With Preserved Ejection Fraction: A Tale of Mice, Rats, and Cats Nada J. Habeichi, Fouad A. Zouein 08/02/22 Journal of the American Heart Association
Triazole fungicide tebuconazole induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway Kevin Monceaux, Anissa Belhadef, Ahmed Karoui, Christophe Lemaire 08/01/22 Environmental Toxicology and Pharmacology
Ferulic Acid, Pterostilbene, and Tyrosol Protect the Heart from ER-Stress-Induced Injury by Activating SIRT1-Dependent Deacetylation of eIF2α Kevin Monceaux, Mélanie Gressette, Ahmed Karoui, Julie Pires Da Silva, Jérôme Piquereau, Renée Ventura-Clapier, Anne Garnier, Mathias Mericskay, Christophe Lemaire 06/01/22 International Journal of Molecular Sciences
Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology Rodolphe Fischmeister 05/01/22 Cardiovascular Research
Insights into the modulation of the interferon response and NAD<sup>+</sup> in the context of COVID-19 Nada J. Habeichi, Mathias Mericskay 01/01/22 International Reviews of Immunology

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)