Lipides : systèmes analytiques et biologiques (Lip(Sys)²)

Laboratory presentation

The Lip(Sys)² is a research unit at the interface between biology, analytical chemistry and biochemistry that seeks to dissect the mechanisms of lipid homeostasis, in particular as regards lipids membranaires with applications in the fields of the atherosclerosis, the dermatology and the cosmetic. It also participates in anthropological projects in which it analyzes lipids from waxes, balms or ointments used by past civilizations. The unit is subdivided into three distinct groups: the atherosclerosis: homeostasis and trafficking of macrophages cholesterol team, the pharmaceutical analytical chemistry team and the LETIAM. Located on the site of the faculty of pharmacy, it benefits from the accessibility and expertise of the technical platforms of IPSIT. Its close connection with the European Hospital George Pompidou ensures a highly competitive translational research.

The 20 latest publications

Title Authors Publication date Source
In vitro Raman imaging of human macrophages: Impact of eicosapentaenoic acid on the hydrolysis of cholesterol esters in lipid droplets Ali Muhieddine, Natalie Fournier, Hani Dakroub, Ali Assi, Jean Louis Paul, Ali Tfayli, Pierre Chaminade, Sana Tfaili 05/01/23 Talanta
Bioinspired Synthesis of Pulvinic Acids Including Xerocomic Acid and Fluorescence Properties of Bis-lactone Intermediates Martin Souce, Athena Kasselouri 02/17/23 European Journal of Organic Chemistry
Glycerol and natural sugar-derived complex modulate differentially stratum corneum water-binding properties and structural parameters in an in vitro Raman-desorption model Ali Tfayli 01/01/23 Journal of Biophotonics
Effects of solar radiations on stratum corneum hydration: Part I, protective role of skin surface lipids Ali Assi, Rime Michael-Jubeli, Arlette Baillet-Guffroy, Ali Tfayli 01/01/23 Journal of Biophotonics
Photosensitizers incorporation in SOPC films at different hydration levels Martin Souce, Ali Tfayli, Athena Kasselouri 01/01/23 Biochimica et Biophysica Acta - Biomembranes
New Cocrystallization Method: Non-photochemical Laser-Induced Nucleation of a Cocrystal of Caffeine-Gallic Acid in Water Dania Mellah, Béatrice Nicolaï, Bertrand Fournier, Nada Bošnjaković-Pavlović, Pascale Gemeiner, Vincent Boemare, Nicolas Guiblin, Anne Spasojević-De Biré 10/05/22 Crystal Growth & Design
Pharmacokinetics, biodistribution, and activity of Amphotericin B-loaded nanocochleates on the Leishmania donovani murine visceral leishmaniasis model Natalie Fournier 08/25/22 International Journal of Pharmaceutics
Estimating the Analytical Performance of Raman Spectroscopy for Quantification of Active Ingredients in Human Stratum Corneum Ali Tfayli 05/01/22 Molecules
Discriminative and quantitative analysis of norepinephrine and epinephrine by surface-enhanced Raman spectroscopy with gold nanoparticle suspensions Antoine Dowek, Marion Berge, Patrice Prognon, Ali Tfayli, Laetitia Minh Mai Lê, Eric Caudron 01/01/22 Analytical and Bioanalytical Chemistry
Towards harmonization of solutions used for cystic fibrosis diagnosis by nasal potential difference measurements: A formulation approach with CHESS® software Eric Caudron, Patrice Prognon 01/01/22 Annales Pharmaceutiques Francaises
The linoleic acid content of the stratum corneum of ichthyotic golden retriever dogs is reduced as compared to healthy dogs and a significant part is oxidized in both free and esterified forms Audrey Solgadi 12/01/21 Metabolites
Investigation of stationary phases performance for eicosanoids profiling in RP-HPLC Kodjo Nouwade, Sana Tfaili, Pierre Chaminade 11/01/21 Analytical and Bioanalytical Chemistry
Eicosapentaenoic acid membrane incorporation stimulates ABCA1-mediated cholesterol efflux from human THP-1 macrophages Benoît Noël 11/01/21 Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Rapid assessment of triacylglycerol fatty acyls composition by LC-APPI<sup>+</sup>-HRMS using monoacylglycerol like fragments intensities Audrey Solgadi 09/15/21 Analytica Chimica Acta
Raman confocal microscopy and biophysics multiparametric characterization of the skin barrier evolution with age Aline Rigal, Rime Michael-Jubeli, Arlette Baillet-Guffroy, Ali Tfayli 09/01/21 Journal of Biophotonics
Prenatal air pollution exposure to diesel exhaust induces cardiometabolic disorders in adulthood in a sex-specific manner Natalie Fournier 09/01/21 Environmental Research
Comprehensive characterization of the structure and properties of human stratum corneum relating to barrier function and skin hydration: modulation by a moisturizer formulation Ali Tfayli, Arlette Baillet-Guffroy 09/01/21 Experimental Dermatology
Assessment of the skin barrier function in the reconstructed human epidermis using a multimodal approach at molecular, tissue and functional levels Joudi Bakar, Rime Michael-Jubeli, Rindala El Khoury, Sabrina Hamla, Ali Assi, Arlette Baillet-Guffroy, Ali Tfayli 07/21/21 The Analyst
The stratum corneum water content and natural moisturization factor composition evolve with age and depend on body site Arlette Baillet-Guffroy 07/01/21 International Journal of Dermatology
Biomolecular modifications during keratinocyte differentiation: Raman spectroscopy and chromatographic techniques Joudi Bakar, Rime Michael-Jubeli, Sana Tfaili, Ali Assi, Arlette Baillet-Guffroy, Ali Tfayli 05/07/21 The Analyst

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)