Intégrité du Génome, ARN et Cancer (GIRC)

Laboratory presentation

The GSC laboratory studies the genetic and genotoxic events that occur in the development of cancers. The work is shared among 8 teams working in synergy on DNA replication, its repair, recombination phenomena, RNA and miRNA regulation, oxidative stress and radiation response.
Integrated in the Orsay Research Center, the GSC benefits from an integrated imaging platform and the numerous technical platforms of the Institut Curie (SGA, experimental radiotherapy, high-throughput DNA sequencing, etc.).

The 20 latest publications

Title Authors Publication date Source
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation Armelle Gesnik, Paloma Fernández-Varela, Virginie Ropars, Jean Baptiste Charbonnier 04/06/23 Molecular Cell
Post-transcriptional polyadenylation site cleavage maintains 3′-end processing upon DNA damage Rym Sfaxi, Biswendu Biswas, Galina Boldina, Mandy Cadix, Martin Dutertre, Stéphan Vagner 04/03/23 EMBO Journal
The tubulin code in mammalian sperm development and function Sudarshan Gadadhar, Carsten Janke 03/15/23 Seminars in Cell and Developmental Biology
Microtubule and auditory function – an underestimated connection Carsten Janke 03/15/23 Seminars in Cell and Developmental Biology
The tubulin code: Empowering microtubules Maria M. Magiera 03/15/23 Seminars in Cell and Developmental Biology
Tubulin polyglutamylation differentially regulates microtubule-interacting proteins Mariya Genova, Maria M. Magiera, Carsten Janke 03/01/23 EMBO Journal
Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells Giulio Prevedello 03/01/23 Journal of Visualized Experiments
Cytidine deaminase deficiency in mice enhances genetic instability but limits the number of chemically induced colon tumors Rosine Onclercq-Delic, Géraldine Buhagiar-Labarchède, Sophie Leboucher, Mounira Amor-Guéret 02/28/23 Cancer Letters
VASH1–SVBP and VASH2–SVBP generate different detyrosination profiles on microtubules Carsten Janke, Maria M. Magiera 02/06/23 Journal of Cell Biology
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus Albertas Navickas 01/01/23 Nature Cell Biology
Loss of primary cilia promotes inflammation and carcinogenesis Carsten Janke 12/06/22 EMBO Reports
Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11 Carsten Janke 12/01/22 Nature Communications
Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations Maria M. Magiera, Carsten Janke 12/01/22 Nature Communications
The multiple roles of LDH in cancer Stéphan Vagner 12/01/22 Nature Reviews Clinical Oncology
Using genetics to predict toxicity of cancer immunotherapy Stéphan Vagner 12/01/22 Nature Medicine
Cytidine deaminase activity increases in the blood of breast cancer patients Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Mounira Amor-Guéret 12/01/22 Scientific Reports
Author Correction: Cytidine deaminase activity increases in the blood of breast cancer patients (Scientific Reports, (2022), 12, 1, (14062), 10.1038/s41598-022-18462-8) Géraldine Buhagiar‑Labarchède, Rosine Onclercq‑Delic, Mounira Amor‑Guéret 12/01/22 Scientific Reports
Preclinical Evaluation of a Novel Small Molecule Inhibitor of LIM Kinases (LIMK) CEL_Amide in Philadelphia-Chromosome Positive (BCR::ABL+) Acute Lymphoblastic Leukemia (ALL) Jacques Ghysdael 11/01/22 Journal of Clinical Medicine
Novel Insights into Redox-Based Mechanisms for Auranofin-Induced Rapid Cancer Cell Death Elie Hatem, Nadine El Banna, Amélie Heneman-Masurel, Dorothée Baïlle, Laurence Vernis, Meng Er Huang 10/01/22 Cancers
Cytidine deaminase deficiency in tumor cells is associated with sensitivity to a naphthol derivative and a decrease in oncometabolite levels Céline Corcelle, Claire Beauvineau, Florence Mahuteau-Betzer 08/01/22 Cellular and Molecular Life Sciences

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)