Biomolécules : conception, isolement, synthèse (BioCIS)

Laboratory presentation

The CNRS BioCIS UMR (Biomolecules: Design, Isolation, Synthesis) is a major player in academic research within the Pharmacy UFR (Paris-Saclay University). It has solid expertise in the field of biologically active natural substances, the development of synthesis methodologies and the rational design of new chemical entities (NECs) for therapeutic purposes. Our research efforts in therapeutic innovation focus primarily on neurodegenerative diseases (eg, synucleinopathies, tauopathies) and rare diseases (PAH, epilepsies), anti-infectious, antiparasitic and anti-tumor agents (eg, immuno-oncology, immunoconjugates). The scientific objective is the search for bioactive NECs in the aforementioned fields. With the establishment of a screening platform (CIBLOT) and the possession of a chemical library (approximately 2000 molecules), the scientific expertise of BioCIS is recognized in the fields of natural and synthetic substances. Our partnership approach with biotechnology companies or national and international pharmaceutical groups on eminently topical research projects and our ability to develop our activity at the chemistry-biology interface (filing of patents) clearly illustrate the successes achieved by BioCIS in the field of therapeutic innovation.