Biomolécules : conception, isolement, synthèse (BioCIS)

Laboratory presentation

The CNRS BioCIS UMR (Biomolecules: Design, Isolation, Synthesis) is a major player in academic research within the Pharmacy UFR (Paris-Saclay University). It has solid expertise in the field of biologically active natural substances, the development of synthesis methodologies and the rational design of new chemical entities (NECs) for therapeutic purposes. Our research efforts in therapeutic innovation focus primarily on neurodegenerative diseases (eg, synucleinopathies, tauopathies) and rare diseases (PAH, epilepsies), anti-infectious, antiparasitic and anti-tumor agents (eg, immuno-oncology, immunoconjugates). The scientific objective is the search for bioactive NECs in the aforementioned fields. With the establishment of a screening platform (CIBLOT) and the possession of a chemical library (approximately 2000 molecules), the scientific expertise of BioCIS is recognized in the fields of natural and synthetic substances. Our partnership approach with biotechnology companies or national and international pharmaceutical groups on eminently topical research projects and our ability to develop our activity at the chemistry-biology interface (filing of patents) clearly illustrate the successes achieved by BioCIS in the field of therapeutic innovation.

The 20 latest publications

Title Authors Publication date Source
Inviting C5-Trifluoromethylated Pseudoprolines into Collagen Mimetic Peptides Keyvan Rahgoshay, Emelyne Renaglia, Nathalie Lensen, Thierry Brigaud, Grégory Chaume 04/10/23 Biomacromolecules
Iron-catalyzed reductive cyclization of nitroarenes: Synthesis of aza-heterocycles and DFT calculations Christine Tran, Aïcha Abdallah, Valentin Duchemann, Abdallah Hamze 03/01/23 Chinese Chemical Letters
Rescue of Dopamine Neurons from Iron-Dependent Ferroptosis by Doxycycline and Demeclocycline and Their Non-Antibiotic Derivatives Laurent Férrié, Bruno Figadère 03/01/23 Antioxidants
Transient imine as a directing group for the Pd-catalyzed anomeric C(sp<sup>3</sup>)-H arylation of 3-aminosugars Juba Ghouilem, Sokna Bazzi, Samir Messaoudi 01/31/23 Chemical Communications
Recent Advances in the Syntheses of N-CF<inf>3</inf> Scaffolds up to Their Valorization Benoît Crousse 01/01/23 Chemical Record
1,2,3-triazenes and 1,2,3-triazoles as antileishmanial, antitrypanosomal, and antiplasmodial agents Bruno Figadère, Blandine Séon-Méniel, Sandrine Cojean, Sébastien Pomel, Philippe M. Loiseau 01/01/23 Medicinal Chemistry Research
Structure-based molecular networking, molecular docking, dynamics simulation and pharmacokinetic studies of Olax subscorpioidea for identification of potential inhibitors against selected cancer targets Mehdi A. Beniddir 01/01/23 Journal of Biomolecular Structure and Dynamics
Site-Selective Palladium(II)-Catalyzed Methylene C(sp<sup>3</sup>)-H Diarylation of a Tropane Scaffold Mayssa Zayene, Franck Le Bideau, Mouad Alami, Samir Messaoudi 12/16/22 Journal of Organic Chemistry
Density functional theory-nuclear magnetic resonance-validated full structure elucidation of theionbrunonine C, an unstable N-oxide theionbrunonine from Mostuea brunonis Elvis Otogo N'Nang, Pierre Champy, Pierre Le Pogam, Mehdi A. Beniddir 12/01/22 Magnetic Resonance in Chemistry
Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application Guillaume Bernadat 12/01/22 Nature Communications
Implementation of a MS/MS database for isoquinoline alkaloids and other annonaceous metabolites Salemon Akpa Agnès, Yvette Affoué Kouadio, Adrien Jagora, Pierre Champy, Mehdi A. Beniddir, Pierre Le Pogam 12/01/22 Scientific data
In vitro efficacy of essential oils against Sarcoptes scabiei Valérie Andriantsoanirina, Rémy Durand 12/01/22 Scientific Reports
Bacteroides fragilis derived metabolites, identified by molecular networking, decrease Salmonella virulence in mice model Pierre Le Pogam 11/10/22 Frontiers in Microbiology
Carbon dots surface chemistry drives fluorescent properties: New tools to distinguish isobaric peptides Kwang Jin Lee, Olivier Monasson, Elisa Peroni 11/01/22 Journal of Colloid and Interface Science
Leptospirosis: A growing health threat to fish farming and recreational activities Philippe M. Loiseau 11/01/22 Annales Pharmaceutiques Francaises
GluN2C selective inhibition is a target to develop new antiepileptic compounds Jean Daniel Brion, Samir Messaoudi, Mouad Alami 11/01/22 Epilepsia
Synthesis and Anti-Leishmanial Properties of Quinolones Derived from Zanthosimuline Indira Dennemont, Sébastien Pomel 11/01/22 Molecules
5-Fluoro-1,2,3-triazole motif in peptides and its electronic properties Jean Michel Gillet, Nour Eddine Ghermani 10/17/22 Organic and Biomolecular Chemistry
Computer-Assisted Design of Sustainable Syntheses of Pharmaceuticals and Agrochemicals from Industrial Wastes Pierre Le Pogam, Mehdi A. Beniddir 10/10/22 ChemSusChem
Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors Camille Hauguel, Olivier Provot, Nada Ibrahim, Diana Lamaa, Coline Balcerowiak, Boris Letribot, Vincent Blanchard, Dolor Renko, Christine Tran, Mouad Alami, Abdallah Hamze 10/05/22 European Journal of Medicinal Chemistry

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)