Intégrité du génome et cancers (IGC)

Présentation du laboratoire

Le laboratoire Stabilité génétique et oncogenèse travaille sur la réponse cellulaire et moléculaire à l'altération de l'ADN. Ces altérations peuvent être responsables d'anomalies du développement, au vieillissement prématuré, à une prédisposition de l'apparition de cancer ou encore une mort cellulaire. Les recherches portent donc sur la compréhension des mécanismes de réparation de l'ADN de cellulaire humaines et murines à partir d'analyses biochimiques, génétiques, moléculaires et cellulaires. Ces travaux ont déjà permis la création de nombreuses innovations protégées par 4 brevets.

Les 20 dernières publications

Titre Auteurs Date de publication Source
A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner Sandrine Ragu, Gabriel Matos-Rodrigues, Gabriella Zarkovic, Elodie Dardillac, Josée Guirouilh-Barbat, Alexander A. Ishchenko, Bernard S. Lopez 01/05/2023 Cell Death and Differentiation
New insights in the molecular regulation of the NADPH oxidase 2 activity: Negative modulation by Poldip2 Ruy A.N. Louzada, Corinne Dupuy 01/04/2023 Free Radical Biology and Medicine
Genome-wide measurement of DNA replication fork directionality and quantification of DNA replication initiation and termination with Okazaki fragment sequencing Nataliya Petryk 01/04/2023 Nature Protocols
From normal hematopoiesis to malignancies: Highlights from the 2021 Meeting of the Club Hematopoiesis and Oncogenesis Dominique Bluteau 01/03/2023 Bulletin du Cancer
Fluorescently labeled human apurinic/apyrimidinic endonuclease APE1 reveals effects of DNA polymerase β on the APE1-DNA interaction Alexander A. Ishchenko, Murat Saparbaev 01/03/2023 DNA Repair
From honeymoon to dysfunction: brown fat remodelling in obesity Caroline Coelho de Faria 15/02/2023 Journal of Physiology
Targeting M2 Macrophages with a Novel NADPH Oxidase Inhibitor Sébastien Dilly, Anny Slama Schwok 01/02/2023 Antioxidants
Caspase Inhibition Modulates Monocyte-Derived Macrophage Polarization in Damaged Tissues Corinne Dupuy, Anny Slama Schwok 01/02/2023 International Journal of Molecular Sciences
Preimplantation genetic testing in patients with genetic susceptibility to cancer Stephane Richard 01/01/2023 Familial Cancer
Monitoring Chk1 kinase activity dynamics in live single cell imaging assays Olivier Gavet 01/01/2023 Methods in Cell Biology
Structural Insights of the DciA Helicase Loader in Its Relationship with DNA Sonia Baconnais, Eric Le Cam 01/01/2023 International Journal of Molecular Sciences
Pre-steady-state kinetic and mutational insights into mechanisms of endo- and exonuclease DNA processing by mutant forms of human AP endonuclease Alexander A. Ishchenko, Murat Saparbaev 01/12/2022 Biochimica et Biophysica Acta - General Subjects
Increased risk of internal tumors in DNA repair-deficient xeroderma pigmentosum patients: analysis of four international cohorts Alain Sarasin 01/12/2022 Orphanet Journal of Rare Diseases
The mechanism of damage recognition by apurinic/apyrimidinic endonuclease Nfo from Escherichia coli Alexander A. Ishchenko, Murat Saparbaev 01/11/2022 Biochimica et Biophysica Acta - General Subjects
Cloning and characterization of the major AP endonuclease from Staphylococcus aureus Murat Saparbaev 01/11/2022 DNA Repair
Prognostic of recurrence and survival in poorly differentiated thyroid cancer Corinne Dupuy 01/11/2022 Endocrine-Related Cancer
Kinetic Features of 3′–5′–Exonuclease Activity of Apurinic/Apyrimidinic Endonuclease Apn2 from Saccharomyces cerevisiae Alexander A. Ishchenko, Murat Saparbaev 01/11/2022 International Journal of Molecular Sciences
Predicting immunotherapy outcomes in patients with MSI tumors using NLR and CT global tumor volume Laetitia Nebot-Bral, Patricia Kannouche, N. Chaput 25/10/2022 Frontiers in Oncology
Percutaneous Thermal Ablation for Renal Tumors in Patients with Birt–Hogg–Dubé Syndrome Stephane Richard 01/10/2022 Cancers
The Kinetic Mechanism of 3′-5′ Exonucleolytic Activity of AP Endonuclease Nfo from E. coli Alexander A. Ishchenko, Murat Saparbaev 01/10/2022 Cells

Nombre de publications du laboratoire par domaine scientifique (2016-2021)

Chaque publication du laboratoire peut être rangée dans une ou plusieurs disciplines scientifiques : la figure ci-dessus présente le nombre de publications du laboratoire pour chaque discipline de la classification ASJC (Elsevier)