Intégrité du génome et cancers (IGC)

Laboratory presentation

The Laboratory Genetic Stability and Oncogenesis works on the cellular and molecular response to DNA alteration. These alterations may be responsible for developmental abnormalities, premature aging, predisposition for the onset of cancer or cell death. The research therefore focuses on understanding the repair mechanisms of human and murine cellular DNA from biochemical, genetic, molecular and cellular analyzes. This work has already led to the creation of numerous innovations protected by 4 patents.

The 20 latest publications

Title Authors Publication date Source
A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner Sandrine Ragu, Gabriel Matos-Rodrigues, Gabriella Zarkovic, Elodie Dardillac, Josée Guirouilh-Barbat, Alexander A. Ishchenko, Bernard S. Lopez 05/01/23 Cell Death and Differentiation
New insights in the molecular regulation of the NADPH oxidase 2 activity: Negative modulation by Poldip2 Ruy A.N. Louzada, Corinne Dupuy 04/01/23 Free Radical Biology and Medicine
Genome-wide measurement of DNA replication fork directionality and quantification of DNA replication initiation and termination with Okazaki fragment sequencing Nataliya Petryk 04/01/23 Nature Protocols
From normal hematopoiesis to malignancies: Highlights from the 2021 Meeting of the Club Hematopoiesis and Oncogenesis Dominique Bluteau 03/01/23 Bulletin du Cancer
Fluorescently labeled human apurinic/apyrimidinic endonuclease APE1 reveals effects of DNA polymerase β on the APE1-DNA interaction Alexander A. Ishchenko, Murat Saparbaev 03/01/23 DNA Repair
From honeymoon to dysfunction: brown fat remodelling in obesity Caroline Coelho de Faria 02/15/23 Journal of Physiology
Targeting M2 Macrophages with a Novel NADPH Oxidase Inhibitor Sébastien Dilly, Anny Slama Schwok 02/01/23 Antioxidants
Caspase Inhibition Modulates Monocyte-Derived Macrophage Polarization in Damaged Tissues Corinne Dupuy, Anny Slama Schwok 02/01/23 International Journal of Molecular Sciences
Preimplantation genetic testing in patients with genetic susceptibility to cancer Stephane Richard 01/01/23 Familial Cancer
Monitoring Chk1 kinase activity dynamics in live single cell imaging assays Olivier Gavet 01/01/23 Methods in Cell Biology
Structural Insights of the DciA Helicase Loader in Its Relationship with DNA Sonia Baconnais, Eric Le Cam 01/01/23 International Journal of Molecular Sciences
Pre-steady-state kinetic and mutational insights into mechanisms of endo- and exonuclease DNA processing by mutant forms of human AP endonuclease Alexander A. Ishchenko, Murat Saparbaev 12/01/22 Biochimica et Biophysica Acta - General Subjects
Increased risk of internal tumors in DNA repair-deficient xeroderma pigmentosum patients: analysis of four international cohorts Alain Sarasin 12/01/22 Orphanet Journal of Rare Diseases
The mechanism of damage recognition by apurinic/apyrimidinic endonuclease Nfo from Escherichia coli Alexander A. Ishchenko, Murat Saparbaev 11/01/22 Biochimica et Biophysica Acta - General Subjects
Cloning and characterization of the major AP endonuclease from Staphylococcus aureus Murat Saparbaev 11/01/22 DNA Repair
Prognostic of recurrence and survival in poorly differentiated thyroid cancer Corinne Dupuy 11/01/22 Endocrine-Related Cancer
Kinetic Features of 3′–5′–Exonuclease Activity of Apurinic/Apyrimidinic Endonuclease Apn2 from Saccharomyces cerevisiae Alexander A. Ishchenko, Murat Saparbaev 11/01/22 International Journal of Molecular Sciences
Predicting immunotherapy outcomes in patients with MSI tumors using NLR and CT global tumor volume Laetitia Nebot-Bral, Patricia Kannouche, N. Chaput 10/25/22 Frontiers in Oncology
Percutaneous Thermal Ablation for Renal Tumors in Patients with Birt–Hogg–Dubé Syndrome Stephane Richard 10/01/22 Cancers
The Kinetic Mechanism of 3′-5′ Exonucleolytic Activity of AP Endonuclease Nfo from E. coli Alexander A. Ishchenko, Murat Saparbaev 10/01/22 Cells

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)