M1 International Track, sino-french program

Students are expected to have a strong background in molecular biology and physiology, including animal reproduction, cell and organ functions, molecular signaling, RNA, DNA and protein structure and functions… notions of microbiology, vegetal biology and organic chemistry will be required too.

Basic Cell Biology – Year 3 Undergraduate, Life Sciences Bachelor’s Degree

I – Introduction to Tissue Engineering
From stem cells to organoids: key concepts and fundamental principles.
II – Applications of Tissue Engineering in Regenerative Medicine
Skin models and tissue regeneration strategies.
III – Applications of Organoids
Modeling neurodegenerative diseases and therapeutic perspectives.

At the end of the unit, the student should be able to analyze and apply the principles and challenges of stem cell- and organoid-based biotherapies in the context of regenerative medicine.

In-person: Lectures, Tutorials, and Laboratory Sessions

12h TP

Acquire fundamental knowledge, apply experimental approaches, analyze scientific data, and collaborate in a team.

Upstream of this course, students should have acquired the basic bases of Immunology, in particular by having followed the unit "Physiology of the Immune System" (UEVE) or another unit of fundamental immunology (M1 and/or Licence-Bachelor). In particular, students should be able to identify the main cells and molecules involved in immune responses. They should also be able to describe the main physiological mechanisms of innate and adaptive immunity.

This course provides a thorough knowledge of genome-wide studies from experimental design to integrative data analysis: Explore genomic variations in both health and disease to understand gene function and regulation of expression at epigenetic and transcriptonal levels, decipher pathogenesis mechanisms, identify therapeutic opportunities and treatments in the context of precision medicine.

-Enumerate and differentiate large-scale sequencing technology driven-approaches at different levels, i.e. genomics, transcriptomics, epigenetic landscapes.
-Determine which technology to use among a broad spectrum of functional genomics methods to address specific biological questions
-Precise the main classification methods œfor patient stratification and identification of co-regulated genes
-Interpret results of large-scale experimental datasets in a scientifically stringent manner
-Critically examine research publications dealing with functional genomics
-Understand how to identify altered signaling pathways, biological process and biomarkers from genes list by functional annotation tools,
-Specify the advantages of single-cell approaches regarding the dynamic of transcriptome, tissue complexity or polyclonal sample content.

présentiel, CM, TD

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