Structure-Activité des Biomolécules Normales et Pathologiques (SABNP)

Présentation du laboratoire

Le laboratoire Structure-Activité des Biomolécules Normales et Pathologiques (SABNP) explore la dynamique et la relation structure-fonction des assemblages macromoléculaires, notamment des complexes ARN-protéines et des microtubules. Les axes de recherche sont les interactions ARN-protéines dans les cancers et les maladies neuronales.

Les 20 dernières publications

Titre Auteurs Date de publication Source
UHMK1 is a novel splicing regulatory kinase Serhii Pankivskyi, Jean de Matha Salone, Alexandre Maucuer 01/04/2023 Journal of Biological Chemistry
An atlas of substrate specificities for the human serine/threonine kinome Alexandre Maucuer 26/01/2023 Nature
Targeting RNA:Protein Interactions with an Integrative Approach Leads to the Identification of Potent YBX1 Inhibitors Krystel El Hage, O. Maciejak, Bénédicte Desforges, Emilie Steiner, Juan Carlos Rengifo-Gonzalez, Hélène Henrie, Marie Jeanne Clément, Vandana Joshi, Ahmed Bouhss, Liya Wang, David Pastré 01/01/2023 eLife
Targeting the Major Groove of the Palindromic d(GGCGCC)<inf>2</inf>Sequence by Oligopeptide Derivatives of Anthraquinone Intercalators Krystel El Hage 26/12/2022 Journal of Chemical Information and Modeling
PARP1 Activation Controls Stress Granule Assembly after Oxidative Stress and DNA Damage Anastasia S. Singatulina, Bénédicte Desforges, Vandana Joshi, David Pastré 01/12/2022 Cells
FUS Microphase Separation: Regulation by Nucleic Acid Polymers and DNA Repair Proteins David Pastré 01/11/2022 International Journal of Molecular Sciences
Physico-chemical properties of aluminum adjuvants in vaccines: Implications for toxicological evaluation Ghidaa Badran, Marie Odile David 05/08/2022 Vaccine
Structural convergence for tubulin binding of CPAP and vinca domain microtubule inhibitors Patrick A. Curmi 10/05/2022 Proceedings of the National Academy of Sciences of the United States of America
A Sub-Micromolar MraY<inf>AA</inf> Inhibitor with an Aminoribosyl Uridine Structure and a (S,S)-Tartaric Diamide: Synthesis, Biological Evaluation and Molecular Modeling Ahmed Bouhss 01/03/2022 Molecules
Identification of a small molecule splicing inhibitor targeting UHM domains Asaki Kobayashi, Marie Jeanne Clément, Krystel El Hage, Jean de Matha Salone, David Pastré, Alexandre Maucuer 01/02/2022 FEBS Journal
YB-1 Structure/Function Relationship in the Packaging of mRNPs and Consequences for Translation Regulation and Stress Granule Assembly in Cells Loic Hamon, David Pastré 01/01/2022 Biochemistry (Moscow)
Meso-substituted cationic 3-and 4-N-Pyridylporphyrins and their Zn(II) derivatives for antibacterial photodynamic therapy Aram G. Gyulkhandanyan 01/01/2022 Journal of Innovative Optical Health Sciences
Publisher Correction: Molecular dynamics of the histamine H3 membrane receptor reveals different mechanisms of GPCR signal transduction (Scientific Reports, (2020), 10, 1, (16889), 10.1038/s41598-020-73483-5) Leonardo David Herrera-Zúñiga, José Correa‑Basurto, David Pastré, Patrick A. Curmi, Rachid C. Maroun 01/12/2021 Scientific Reports
YB-1 unwinds mRNA secondary structures in vitro and negatively regulates stress granule assembly in HeLa cells Karina Budkina, Krystel El Hage, Marie Jeanne Clément, Bénédicte Desforges, Ahmed Bouhss, Vandana Joshi, Alexandre Maucuer, Loic Hamon, David Pastré 27/09/2021 Nucleic Acids Research
The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation Juan Carlos Rengifo-Gonzalez, Krystel El Hage, Marie Jeanne Clément, Emilie Steiner, Vandana Joshi, David Pastré, Ahmed Bouhss 01/09/2021 eLife
Synthesis, biological evaluation and molecular modeling of urea-containing MraY inhibitors Ahmed Bouhss 14/07/2021 Organic and Biomolecular Chemistry
PURE mRNA display and cDNA display provide rapid detection of core epitope motif via high-throughput sequencing Asaki Kobayashi 01/04/2021 Biotechnology and Bioengineering
ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs Serhii Pankivskyi, David Pastré, Emilie Steiner, Vandana Joshi, Loic Hamon 01/02/2021 Cellular and Molecular Life Sciences
Getting to know each other: PPIMem, a novel approach for predicting transmembrane protein-protein complexes Aram Gyulkhandanian, Rachid C. Maroun 01/01/2021 Computational and Structural Biotechnology Journal
Molecular dynamics of the histamine H3 membrane receptor reveals different mechanisms of GPCR signal transduction Leonardo David Herrera-Zúñiga, José Correa-Basurto, David Pastré, Patrick A. Curmi, Rachid C. Maroun 01/12/2020 Scientific Reports

Nombre de publications du laboratoire par domaine scientifique (2016-2021)

Chaque publication du laboratoire peut être rangée dans une ou plusieurs disciplines scientifiques : la figure ci-dessus présente le nombre de publications du laboratoire pour chaque discipline de la classification ASJC (Elsevier)