Laboratoire Européen de Recherche pour la Polyarthrite rhumatoïde (GENHOTEL)

Laboratory presentation

GenHotel's goal is to clarify the multifactorial determinism of rheumatoid arthritis. In this context, research activities focus on characterization of sequencing, structural and expression variants from genomic data of patients and their families. Interaction between risk factors is also investigated.

We also develop a computational systems biology approach with the reconstruction of a disease-specific interaction network by integrating small scale and multi-omic data, and the automatic inference of a large scale boolean model in order to perform dynamical studies and in silico simulations.

The final purpose is to contribute to new drug target development, with a view to prevent and cure this disease. The research methodology will be extended to other diseases having a major impact on public health, through national and international collaborations.

The 20 latest publications

Title Authors Publication date Source
Metabolic reprogramming in Rheumatoid Arthritis Synovial Fibroblasts: A hybrid modeling approach Sahar Aghakhani, Anna Niarakis 12/01/22 PLoS Computational Biology
Addressing barriers in comprehensiveness, accessibility, reusability, interoperability and reproducibility of computational models in systems biology Henning Hermjakob 07/01/22 Briefings in Bioinformatics
Toehold switch based biosensors for sensing the highly trafficked rosewood Dalbergia maritima Anna Niarakis 06/01/22 Synthetic and Systems Biotechnology
Temporal Gene Expression Profiles Reflect the Dynamics of Lymphoid Differentiation Diana Tronik-Le Roux 02/01/22 International Journal of Molecular Sciences
Boolean modelling as a logic-based dynamic approach in systems medicine Anna Niarakis 01/01/22 Computational and Structural Biotechnology Journal
COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms Anna Niarakis, Vidisha Singh 10/01/21 Molecular Systems Biology
Inference of an integrative, executable network for rheumatoid arthritis combining data-driven machine learning approaches and a state-of-the-art mechanistic disease map Quentin Miagoux, Vidisha Singh, Dereck de Mézquita, Valerie Chaudru, Elisabeth Petit-Teixeira, Anna Niarakis 08/01/21 Journal of Personalized Medicine
A practical guide to mechanistic systems modeling in biology using a logic-based approach Anna Niarakis 07/01/21 Briefings in Bioinformatics
The status of causality in biological databases: Data resources and data retrieval possibilities to support logical modeling Anna Niarakis 07/01/21 Briefings in Bioinformatics
Identification of biological pathways specific to phases preceding rheumatoid arthritis development through gene expression profiling Maëva Veyssiere, Elisabeth Petit-Teixeira 06/01/21 International Journal of Immunogenetics
Metabolic reprogramming of fibroblasts as therapeutic target in rheumatoid arthritis and cancer: Deciphering key mechanisms using computational systems biology approaches Sahar Aghakhani, Naouel Zerrouk, Anna Niarakis 01/01/21 Cancers
Identification of putative master regulators in rheumatoid arthritis synovial fibroblasts using gene expression data and network inference Naouel Zerrouk, Quentin Miagoux, Anna Niarakis 12/01/20 Scientific Reports
Automated inference of Boolean models from molecular interaction maps using CaSQ Sara Sadat Aghamiri, Vidisha Singh, Anna Niarakis 08/15/20 Bioinformatics
Computational complexity: An empirical view Maël Pégny 12/01/13 6th AISB Symposium on Computing and Philosophy: The Scandal of Computation - What is Computation? - AISB Convention 2013
RA-map: building a state-of-the-art interactive knowledge base for rheumatoid arthritis Vidisha Singh, Maëva Veyssiere, Elisabeth Petit-Teixeira, Anna Niarakis 01/01/20 Database : the journal of biological databases and curation
Association study of copy number variants in CCL3L1, FCGR3A and FCGR3B genes with risk of ankylosing spondylitis in a West Algerian population Elisabeth Petit-Teixeira 12/01/19 International Journal of Immunogenetics
Community-driven roadmap for integrated disease maps Anna Niarakis 03/22/19 Briefings in Bioinformatics
A novel nonsense variant in SUPT20H gene associated with Rheumatoid arthritis identified by whole exome sequencing of multiplex families Maëva Veyssiere, Javier Perea, Elisabeth Petit-Teixeira, Valerie Chaudru 03/01/19 PLoS ONE
Effects of proteasome inhibitors on cytokines, metalloproteinases and their inhibitors and collagen type-I expression in periprosthetic tissues and fibroblasts from loose arthroplasty endoprostheses Anna Niarakis 01/01/19 Connective Tissue Research
Measurement of absolute copy number variation of Glutathione S-Transferase M1 gene by digital droplet PCR and association analysis in Tunisian Rheumatoid Arthritis population Mohamed Sahbi Ben Kilani, Elisabeth Petit-Teixeira 03/01/18 Journal of Clinical Laboratory Analysis

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)