Laboratoire de biologie et pharmacologie appliquée (LBPA)

Laboratory presentation

The research carried out at LBPA focuses on the fields of anti-tumoral and antiviral pharmacology, and on the study of pathogen bacteria. At the most fundamental level, LBPA studies the molecular mechanisms involved in several pahologies via research ranging from macromolecular interactions to thedaynmics of the interactions in complex nucleoproteic systems. This research is made possible by a considerable technological expertise including, for instance, the use of mass spectrometry, biophotonics and time-resolved fluorescence, molecular photonics, NMR, cellular imaging (multiphoton, FLIM, FCS....), level 2 and 3 cellular growth facilites, and bio-sensor systems.
As an entity, LBPA is attached to IDA (Institut d'Alembert).

The 20 latest publications

Title Authors Publication date Source
Shigella IpaA mediates actin bundling through diffusible vinculin oligomers with activation imprint Benjamin Cocom-Chan, Yosra Zarrouk, Christophe Le Clainche, Guy Tran Van Nhieu 04/25/23 Cell Reports
Defining the role of the N-terminal helix in the Arf1 nucleotide switch transition using pressure perturbation Jacqueline Cherfils 02/10/23 Biophysical Journal
Effect of phosphorylation on the structural dynamics, thermal stability of human dopamine transporter: A simulation study using normal modes, molecular dynamics and Markov State Model D. Perahia 01/01/23 Journal of Molecular Graphics and Modelling
Mechanistic target of rapamycin (mTOR) regulates self-sustained quiescence, tumor indolence, and late clinical metastasis in a Beclin-1-dependent manner Maryline Havard, Fanny Laurent-Tchenio, François Dautry 01/01/23 Cell Cycle
The Autophagy Receptor TAX1BP1 (T6BP) improves antigen presentation by MHC-II molecules Clemence Richetta, Frédéric Subra, Olivier Delelis 12/06/22 EMBO Reports
Different Pathways Conferring Integrase Strand-Transfer Inhibitors Resistance Clemence Richetta, Nhat Quang Tu, Olivier Delelis 12/01/22 Viruses
Recent advances in applying G-quadruplex for SARS-CoV-2 targeting and diagnosis: A review Xu Guang Xi 11/30/22 International Journal of Biological Macromolecules
Bloom Syndrome Helicase Compresses Single-Stranded DNA into Phase-Separated Condensates Xu Guang Xi 09/26/22 Angewandte Chemie - International Edition
Targeting the RNA G-Quadruplex and Protein Interactome for Antiviral Therapy Xu Guang Xi 08/11/22 Journal of Medicinal Chemistry
Recognition of tRNA<sup>Ile</sup> with a UAU anticodon by isoleucyl-tRNA synthetase in lactic acid bacteria Satoko Yoshizawa 08/01/22 FEBS Journal
Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration Clemence Richetta, Frédéric Subra, Hervé Leh, Eric Deprez, Olivier Delelis 07/01/22 Journal of Virology
Investigation of the Low-Populated Excited States of the HIV-1 Nucleocapsid Domain Loussiné Zargarian, Anissa Belfetmi, Marco Pasi, Olivier Mauffret 03/01/22 Viruses
MDexciteR: Enhanced Sampling Molecular Dynamics by Excited Normal Modes or Principal Components Obtained from Experiments Mauricio G.S. Costa, D. Perahia 01/01/22 Journal of Chemical Theory and Computation
Sequence-dependent structural properties of B-DNA: what have we learned in 40 years? Marco Pasi 12/01/21 Biophysical Reviews
Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations Balint Dudas, D. Perahia 12/01/21 Scientific Reports
Antitumor activity and mechanism of action of hormonotoxin, an lhrh analog conjugated to dermaseptin-b2, a multifunctional antimicrobial peptide Loussiné Zargarian 11/01/21 International Journal of Molecular Sciences
G-quadruplex DNA: a novel target for drug design Xu Guang Xi 10/01/21 Cellular and Molecular Life Sciences
Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor Mauricio G.S. Costa, D. Perahia 09/01/21 eLife
Multimolecular complexes of the phosphodiester anion with Zn(II) or Mg(II) and water molecules—Preliminary validations of a polarizable potential by ab initio quantum chemistry D. Perahia 07/30/21 Journal of Computational Chemistry
Modulation of Cellular Fate of Vinyl Triarylamines through Structural Fine Tuning: To Stay or Not To Stay in the Mitochondria? Rahima Chennoufi, Eric Deprez 07/15/21 ChemBioChem

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)