Institut de Chimie des Substances Naturelles (ICSN)

Laboratory presentation

With a staff of nearly 200 people, ICSN is the chemistry center of the CNRS campus of Gif-sur-Yvette. The Institute is located on the edge of the future Paris-Saclay campus, which will bring together nearly 10% of French research, and is an integral part of this new University. The ICSN develops activities at the chemistry-biology interface, with natural substances as object of study and main source of inspiration.
Organized in four departments, it has multidisciplinary expertise in organic exploratory chemistry, medicinal chemistry and natural substances, biological chemistry, and structural and analytical biology and chemistry. It relies on state-of-the-art equipment and researchers and engineers with unique know-how.
Internationally, it coordinates numerous national and European research projects. At the origin of many valued patents and startups, the ICSN regularly collaborates with small and large companies in the pharmaceutical and agro-food fields.

The 19 latest publications

Title Authors Publication date Source
Total Synthesis of (−)-HM-3 and (−)-HM-4 Using an Asymmetric Gold-Catalyzed [3,3]-Sigmatropic Rearrangement of Sulfonium Weiping Zhou, Arnaud Voituriez 05/02/23 European Journal of Organic Chemistry
PSL Chemical Biology Symposia Third Edition: A Branch of Science in its Explosive Phase Boris Vauzeilles, Géraldine Masson 04/17/23 ChemBioChem
EFMC: Trends in Medicinal Chemistry and Chemical Biology Boris Vauzeilles 04/03/23 ChemBioChem
Design and Synthesis of Chemiluminescent Cassettes Based on Energy Transfer Philippe Durand 04/03/23 European Journal of Organic Chemistry
Redox-Based Strategies against Infections by Eukaryotic Pathogens Cindy Vallières, Marie Pierre Golinelli-Cohen, Olivier Guittet, Michel Lepoivre, Meng Er Huang, Laurence Vernis 04/01/23 Genes
Clarifying the Configuration of Pandamine by an Extensive Spectroscopic Reinvestigation of the Authentic 1964 Sample Pascal Retailleau, Jean François Gallard 04/01/23 Metabolites
Structural basis of odorant recognition by a human odorant receptor Claire A. de March 03/23/23 Nature
Heteroaryl-Substituted Bis-Anils: Aggregation-Induced Emission (AIE) Derivatives with Tunable ESIPT Emission Color and pH Sensitivity Pascal Retailleau 03/07/23 Chemistry - A European Journal
A molecular device for the redox quality control of GroEL/ES substrates Bogdan I. Iorga 03/02/23 Cell
Investigation of the Influence of Functionalization Strategy on Urea 2D MOF Catalytic Performance Pascal Retailleau 02/27/23 Inorganic Chemistry
Tuning the nuclearity of [Mo<inf>2</inf>O<inf>2</inf>S<inf>2</inf>]<sup>2+</sup>-based assemblies by playing with the degree of flexibility of bis-thiosemicarbazone ligands Vincent Guérineau, David Touboul 02/07/23 Dalton Transactions
N-Metallocenyl Ynamides: Preparation, Reactivity, and Synthesis of ansa[3]-Ferrocenylamides Capucine Mahe 02/03/23 Organic Letters
Rim-differentiation vs. mixture of constitutional isomers: A binding study between pillar[5]arene-based glycoclusters and lectins from pathogenic bacteria Sébastien Vidal 02/01/23 Chinese Chemical Letters
Structural and Biochemical Features of OXA-517: a Carbapenem and Expanded-Spectrum Cephalosporin Hydrolyzing OXA-48 Variant Laura Dabos, Delphine Girlich, Rémy A. Bonnin, Laurent Dortet, Aurélie Peyrat, Thierry Naas 02/01/23 Antimicrobial Agents and Chemotherapy
Ominoxanthone-The First Xanthone Linearly Fused to a γ-Lactone from Cortinarius ominosus Bidaud Basidiomata. CASE- and DFT-Based Structure Elucidation Jean François Gallard 02/01/23 Molecules
Transient imine as a directing group for the Pd-catalyzed anomeric C(sp<sup>3</sup>)-H arylation of 3-aminosugars Juba Ghouilem, Sokna Bazzi, Samir Messaoudi 01/31/23 Chemical Communications
Multi-functionalized MOFs with large-pore apertures as luminescent probes for efficient sensing of quinones Pascal Retailleau 01/26/23 New Journal of Chemistry
VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites Fanny Roussi 01/23/23 Developmental Cell
In vitro evaluation of NA1-115-7-loaded nanoemulsions, an MCL-1-specific inhibitor of natural origin, intended to treat B-cell lymphoproliferative disorders after oral administration Florian Daressy, Vincent Dumontet, Marc Litaudon, Cécile Appel, Fanny Roussi 01/05/23 International Journal of Pharmaceutics

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)