Hémostase, inflammation, thrombose (HITh)

Laboratory presentation

The Hemostasis, Inflammation and Thrombosis Unit is interested in the platelets biology and associated cardiovascular diseases. This well-defined research perimeters, hospital involvement and the I2B's technical resources at the Bicêtre hospital site offer high international visibility. It brings together two synergistic teams, each made up of biologists and clinicians. Team 1 studies the physiology of haemostasis and its pathological aspects, focusing particularly on haemorrhagic pathologies, such as hemophilia, Willebrand disease, filaminopathies, gray platelet syndrome or Scott\'s syndrome. In addition, this team is in charge of the nanobodies synthesis, new tools created from antibodies for the study of biological phenomena and the treatment of pathologies. Team 2 is interested in the communication between inflammation and hemostasis and its implications in vascular pathologies as well as in platelet and endothelial calcium homeostasis. Some projects are of a fundamental nature while another aspect aims to develop new therapies.

The 20 latest publications

Title Authors Publication date Source
von Willebrand factor: from figurant to main character in the scene of inflammation Peter J. Lenting, Alexis Texier, Caterina Casari 04/01/23 Journal of Thrombosis and Haemostasis
Development of a dual hybrid AAV vector for endothelial-targeted expression of von Willebrand factor Elena Barbon, Solenne Marmier, Aboud Sakkal, Fanny Collaud, Severine Charles, Giuseppe Ronzitti, Federico Mingozzi 04/01/23 Gene Therapy
A nanobody against the VWF A3 domain detects ADAMTS13-induced proteolysis in congenital and acquired VWD Claire Kizlik-Masson, Ivan Peyron, Stéphane Gangnard, Stéphanie Roullet, Olivier D. Christophe, Cécile V. Denis, Caterina Casari, Peter J. Lenting 03/23/23 Blood
Persistent Opacification of the Woven EndoBridge Device: A Conebeam CT Analysis of the Bicêtre Occlusion Scale Score 1 Phenomenon J. Caroff 03/01/23 American Journal of Neuroradiology
Stratification of COVID-19 Severity Using SeptiCyte RAPID, a Novel Host Immune Response Test Tiffany Pascreau, Marc Vasse 02/01/23 Viruses
Prognostic value of cellular population data in patients with COVID-19 Marc Vasse, Tiffany Pascreau 01/01/23 Informatics in Medicine Unlocked
Soluble endoglin reduces thrombus formation and platelet aggregation via interaction with αIIbβ3 integrin Alexandre Kauskot 01/01/23 Journal of Thrombosis and Haemostasis
Niemann-Pick C1 protein regulates platelet membrane–associated calcium ion signaling in thrombo-occlusive diseases in mice Régis Bobe 01/01/23 Journal of Thrombosis and Haemostasis
DOCK11 deficiency in patients with X-linked actinopathy and autoimmunity Alexandre Kauskot, Jean Solarz, Christelle Repérant, Frédéric Adam 01/01/23 Blood
Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in von Willebrand disease murine models Stéphanie Roullet, Jean Solarz, Thibaud Sefiane, Frédéric Adam, Caterina Casari, Olivier D. Christophe, Peter J. Lenting, Cecile V. Denis 01/01/23 Blood
Are Viscoelastometric Assays of Old Generation Ready for Disposal? Comment on Volod et al. Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices. J. Clin. Med. 2022, 11, 860 Stéphanie Roullet 01/01/23 Journal of Clinical Medicine
A gain-of-function filamin A mutation in mouse platelets induces thrombus instability Frédéric Adam, Alexandre Kauskot, Lamia Lamrani, Jean Solarz, Christelle Soukaseum, Christelle Repérant, Cecile V. Denis, Jean Philippe Rosa, Marijke Bryckaert 11/01/22 Journal of Thrombosis and Haemostasis
Challenges facing early career women in thrombosis and hemostasis—meeting the needs of the next generation Caterina Casari 11/01/22 Journal of Thrombosis and Haemostasis
A French Real-World Evidence Study Evaluating the Efficacy, Safety, and Pharmacokinetic Parameters of rVIII-SingleChain in Patients with Hemophilia A Receiving Prophylaxis Roseline D'Oiron 10/04/22 Thrombosis and Haemostasis
Author Correction: Long-term safety and efficacy of lentiviral hematopoietic stem/progenitor cell gene therapy for Wiskott–Aldrich syndrome (Nature Medicine, (2022), 28, 1, (71-80), 10.1038/s41591-021-01641-x) A. Galy 10/01/22 Nature Medicine
Von Willebrand factor and cancer: Another piece of the puzzle Cecile V. Denis, Stéphanie Roullet 10/01/22 Journal of Thrombosis and Haemostasis
How to keep the factor VIII/von Willebrand factor complex in the circulation Cecile V. Denis, Peter J. Lenting 09/01/22 Haematologica
N -Glycosylation Deficiency Reduces the Activation of Protein C and Disrupts Endothelial Barrier Integrity Tiffany Pascreau, François Saller, Elsa P. Bianchini, Dominique Lasne, Christelle Repérant, Cecile V. Denis, Delphine Borgel 08/28/22 Thrombosis and Haemostasis
Antithrombotic potential of a single-domain antibody enhancing the activated protein C-cofactor activity of protein S Josepha C. Sedzro, Frédéric Adam, Claire Auditeau, Elsa P. Bianchini, Allan De Carvalho, Ivan Peyron, Sadyo Daramé, Olivier D. Christophe, Peter J. Lenting, Cecile V. Denis, Delphine Borgel, François Saller 07/01/22 Journal of Thrombosis and Haemostasis
Impact of COVID-19 on Subclinical Placental Thrombosis and Maternal Thrombotic Factors Marc Vasse 07/01/22 Journal of Clinical Medicine

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)