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M2 Systems and Synthetic Biology

Apply for the degree
  • Places available
    15
  • Language(s) of instruction
    English
Présentation
Objectives

The vigorous development of Systems and Synthetic Biology constitutes a huge challenge that must be met both from the research and education perspectives. M2 SSB represents the first step towards nurturing a new brand of researchers and engineers to face up to the challenge.
The aim of M2 SSB is to provide students from the Life Sciences, Mathematics, Engineering, Chemistry, Physical and Computer Sciences a mean to fruitfully engage in collaborative work across disciplinary boundaries, with applications in Systems & Synthetic Biology. Students undertaking the course will gain hands-on experience in experimental biology, modeling and designing. They will also enhance transversal capacities including planning a project, giving a seminar, perceiving the industrial, economical and ethical issues associated with these developing fields.

Location
EVRY
Course Prerequisites

Applicants may come from Universities or from Engineering schools. After a first year of master (M1), or an equivalent qualification (4 years of successful higher education after finishing high-school), in either Biology, applied Mathematics, Computer Science, Chemistry or Physics. Bi-disciplinary curriculums including biology is favored, but highly-achieving and motivated students in any of the cited disciplines can apply.

Skills
  • Apply engineering approaches to biology.

  • Design, model and predict the behavior of biological synthetic parts, circuits and chassis.

  • Recommend and execute experimental plans to engineer and test synthetic biological systems.

  • Integrate concepts and technologies across disciplinary boundaries.

  • Conceive and develop collaborative research work within interdisciplinary teams with applications in Systems & Synthetic Biology (iGEM).

  • Anticipate the economical and societal challenges of synthetic biology to plan future career paths.

Post-graduate profile

About 70% of students in previous classes pursue doctoral studies, while others hold research-engineering positions in the biotechnology and pharmaceutical industries or in academic research laboratories. Moreover, several previous graduates are founders of biotech startups.

Career prospects

The professional perspectives of M2 SSB lie in the massive development of Synthesis Biology, and the orientation of the biotechnology and pharmaceutical industry towards the use of predictive models and the modeling of biological systems.
About 70% of students in previous classes pursue doctoral studies, while others hold research-engineering positions in the biotechnology and pharmaceutical industries or in academic research laboratories. Moreover, several previous graduates are founders of biotech startups.

Collaboration(s)
Laboratories

Génomique métabolique - DRF/JACOB/Génoscope
MICrobiologie de l'ALImentation au Service de la Santé Humaine
Informatique, Biologie Intégrative & Systèmes Complexes
Laboratoire de Mathématiques et Modélisation d'Evry
Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement
Mathématiques et Informatique Appliquées du Génome à l'Environnement
Laboratoire Européen de Recherche pour la Polyarthrite rhumatoïde
Institut Jean-Pierre Bourgin.

Laboratoire Jean-Perrin (UMR 8237 CNRS - Sorbonne Université)
Molécules Thérapeutique In Silico (Mti, U 973 Inserm - Université Paris Diderot)
SYNBIOCHEM, Manchester Institute of Biotechnology, Royaume-Uni.

Programme

During the first semester, from September to end of January, students must attend 5 core compulsory modules and 5 elective modules (chosen among 11), for a total of 30 European Credits (ECTS). Refresher courses in either biology or mathematics and computer science are also proposed.

Subjects ECTS Lecture directed study practical class Lecture/directed study Lecture/practical class directed study/practical class distance-learning course Project Supervised studies
Introduction to Biology 0 8 32
Introduction to Mathematics and Computer Science for Biology 0 18 22
Subjects ECTS Lecture directed study practical class Lecture/directed study Lecture/practical class directed study/practical class distance-learning course Project Supervised studies
Cell Factory Design 2.5 11 3 6
Chips for Molecular Evolution 2.5 20
Computational Inference and Modeling of Biological Networks 2.5 6 14
Computational Protein Design 2.5 12 8
Design of Experiments and Machine Learning in Synthetic Biology 2.5 20
Environmental Biotech and Upstream Processing 2.5 20
Industrial Biotech and Downstream Processing 2.5 12.5 7.5
Nanobiology 2.5 12 8
Network Systems: Modeling and Analysis 2.5 20
Rational Protein Engineering 2.5 20
Statistical Analysis of Large Scale Gene Expression Data 2.5 20
Subjects ECTS Lecture directed study practical class Lecture/directed study Lecture/practical class directed study/practical class distance-learning course Project Supervised studies
Biological Parts and Devices 3.5 11 9
Biosafety and Ethical Questions of Synthetic Biology 2 10
Genome Engineering 3.5 11 3 6
Metabolic Engineering 3.5 12 8
Synthetic Biology Practical Course 5 45

The second semester, from February to end of July, consists in a 6–months research training. Students may perform this internship in one of the academic laboratories or biotechnology companies located on site or elsewhere in France or abroad.

Subjects ECTS Lecture directed study practical class Lecture/directed study Lecture/practical class directed study/practical class distance-learning course Project Supervised studies
Research Internship 30 40
Modalités de candidatures
Application period
From 15/01/2024 to 04/07/2024
Compulsory supporting documents
  • Motivation letter.

  • All transcripts of the years / semesters validated since the high school diploma at the date of application.

  • Curriculum Vitae.

Additional supporting documents
  • Letter of recommendation or internship evaluation.

    (or the names and addresses of 2 referees)
  • Document at your convenience.

    (any other document that you consider important for the evaluation of your application)
  • VAP file (obligatory for all persons requesting a valuation of the assets to enter the diploma).

  • Supporting documents :
    - Residence permit stating the country of residence of the first country
    - Or receipt of request stating the country of first asylum
    - Or document from the UNHCR granting refugee status
    - Or receipt of refugee status request delivered in France
    - Or residence permit stating the refugee status delivered in France
    - Or document stating subsidiary protection in France or abroad
    - Or document stating temporary protection in France or abroad.

Contact(s)
Course manager(s)
Jean-Loup Faulon - jean-loup.faulon@inra.fr
Matthieu JULES - matthieu.jules@inrae.fr
Admission