M2 Systems and Synthetic Biology

Apply for the degree
  • Places available
    15
  • Language(s) of instruction
    English
Présentation
Objectives

The vigorous development of Systems and Synthetic Biology constitutes a huge challenge that must be met both from the research and education perspectives. M2 SSB represents the first step towards nurturing a new brand of researchers and engineers to face up to the challenge.
The aim of M2 SSB is to provide students from the Life Sciences, Mathematics, Engineering, Chemistry, Physical and Computer Sciences a mean to fruitfully engage in collaborative work across disciplinary boundaries, with applications in Systems & Synthetic Biology. Students undertaking the course will gain hands-on experience in experimental biology, modeling and designing. They will also enhance transversal capacities including planning a project, giving a seminar, perceiving the industrial, economical and ethical issues associated with these developing fields.

Location
EVRY
Course Prerequisites
Applicants may come from Universities or from Engineering schools. After a first year of master (M1), or an equivalent qualification (4 years of successful higher education after finishing high-school), in either Biology, applied Mathematics, Computer Science, Chemistry or Physics. Bi-disciplinary curriculums including biology is favored, but highly-achieving and motivated students in any of the cited disciplines can apply.
Skills
  • Apply engineering approaches to biology.

  • Design, model and predict the behavior of biological synthetic parts, circuits and chassis.

  • Recommend and execute experimental plans to engineer and test synthetic biological systems.

  • Integrate concepts and technologies across disciplinary boundaries.

  • Conceive and develop collaborative research work within interdisciplinary teams with applications in Systems & Synthetic Biology (iGEM).

  • Anticipate the economical and societal challenges of synthetic biology to plan future career paths.

Post-graduate profile

About 70% of students in previous classes pursue doctoral studies, while others hold research-engineering positions in the biotechnology and pharmaceutical industries or in academic research laboratories. Moreover, several previous graduates are founders of biotech startups.

Career prospects

The professional perspectives of M2 SSB lie in the massive development of Synthesis Biology, and the orientation of the biotechnology and pharmaceutical industry towards the use of predictive models and the modeling of biological systems.
About 70% of students in previous classes pursue doctoral studies, while others hold research-engineering positions in the biotechnology and pharmaceutical industries or in academic research laboratories. Moreover, several previous graduates are founders of biotech startups.

Collaboration(s)
Laboratories

Génomique métabolique - DRF/JACOB/Génoscope
MICrobiologie de l'ALImentation au Service de la Santé Humaine
Informatique, Biologie Intégrative & Systèmes Complexes
Laboratoire de Mathématiques et Modélisation d'Evry
Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement
Mathématiques et Informatique Appliquées du Génome à l'Environnement
Laboratoire Européen de Recherche pour la Polyarthrite rhumatoïde
Institut Jean-Pierre Bourgin.

Laboratoire Jean-Perrin (UMR 8237 CNRS - Sorbonne Université)
Molécules Thérapeutique In Silico (Mti, U 973 Inserm - Université Paris Diderot)
SYNBIOCHEM, Manchester Institute of Biotechnology, Royaume-Uni.

Programme

During the first semester, from September to end of January, students must attend 5 core compulsory modules and 5 elective modules (chosen among 11), for a total of 30 European Credits (ECTS). Refresher courses in either biology or mathematics and computer science are also proposed.

Matières ECTS Cours TD TP Cours-TD Cours-TP TD-TP A distance Projet Tutorat
Introduction to Mathematics and Computer Science for Biology 0 18 22
Introduction to Biology 0 8 32
Matières ECTS Cours TD TP Cours-TD Cours-TP TD-TP A distance Projet Tutorat
Statistical Analysis of Large Scale Gene Expression Data 2.5 20
Rational Protein Engineering 2.5 20
Network Systems: Modeling and Analysis 2.5 20
Nanobiology 2.5 12 8
Industrial Biotech and Downstream Processing 2.5 12.5 7.5
Environmental Biotech and Upstream Processing 2.5 20
Design of Experiments and Machine Learning in Synthetic Biology 2.5 20
Computational Protein Design 2.5 12 8
Computational Inference and Modeling of Biological Networks 2.5 6 14
Chips for Molecular Evolution 2.5 20
Cell Factory Design 2.5 11 3 6
Matières ECTS Cours TD TP Cours-TD Cours-TP TD-TP A distance Projet Tutorat
Synthetic Biology Practical Course 5 45
Metabolic Engineering 3.5 12 8
Genome Engineering 3.5 11 3 6
Biosafety and Sociological Questions on Synthetic Biology 2 10
Biological Parts and Devices 3.5 11 9

The second semester, from February to end of July, consists in a 6–months research training. Students may perform this internship in one of the academic laboratories or biotechnology companies located on site or elsewhere in France or abroad.

Matières ECTS Cours TD TP Cours-TD Cours-TP TD-TP A distance Projet Tutorat
Research Internship 30 40
Modalités de candidatures
Application period
From 15/01/2020 to 06/09/2020
Compulsory supporting documents
  • Curriculum Vitae.

  • Motivation letter.

  • All transcripts of the years / semesters validated since the high school diploma at the date of application.

Additional supporting documents
  • VAP file (obligatory for all persons requesting a valuation of the assets to enter the diploma).

  • Letter of recommendation or internship evaluation.

    (or the names and addresses of 2 referees)
  • Document at your convenience.

    (any other document that you consider important for the evaluation of your application)
Contact(s)
Course manager(s)
Jean-Loup Faulon - jean-loup.faulon@inra.fr
Jules Matthieu - matthieu.jules@inra.fr