Jacqueline Cherfils: from molecular switches to drugs
… of proteins (classified into five main subfamilies: RAS, RAB, RHO, RAN and ARF), which control most of our cells' … inactive (OFF) to the active (ON) state , and shortly afterwards the first structure of a GTPase-activating protein. … cell biology, brefeldin A, the only GTPase inhibitor that was known at the time. In 2003, the biologist and her team …
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