Journée scientifique GS LSH - CRISPR tools: more than a knockout
Présentation
La Graduate School Life Sciences and Health (GS LSH) organise sa 10ème journée scientifique intitulée "CRISPR tools: more than a knockout" le mardi 24 juin 2025 dans l'amphithéâtre Olivier Kahn à Henri Moissan (HM2), 17 avenue des Sciences, 91400 Orsay.
Objectifs : présenter les dernières avancées en matière d'outils CRISPR et favoriser la collaboration entre laboratoires.
Ce colloque se déroulera en présentiel de 8h30 à 18h et accueillera trois keynote :
- Christine Pourcel, Institute for Integrative Biology of the Cell
- Eric Batsché, Institut de Biologie Paris-Seine
- Hervé Vaucheret, Institut Jean-Pierre Bourgin
INSCRIPTION
Gratuite mais obligatoire avant le 3 juin
Programme
8h30 Welcome participants
9h00 A word from the graduate school life sciences and health - Philippe Noirot
9h10 Introduction - Alessia Zamborlini (IMVA-HB, INSERM U1184/CEA/Univ. Paris Saclay)
Chairpersons: Alessia Zamborlini and Daan Noordermeer
9h30 Christine Pourcel (Institute for Integrative Biology of the Cell, UMR 9198)
The CRISPR-Cas system: a key player in the control of genomic exchanges in prokaryotes
Session 1 - Genome editing plateforms at Paris Saclay
10h15 Jean-Pierre Levraud/Axel Benchetrit (Institut des Neurosciences Paris-Saclay, UMR 9197)
Genome editing of zebrafish in TEFOR Paris-Saclay: KO, KI and more
10h30 Coffee break
11h00 Joanne Edouard (Institute for Integrative Biology of the Cell, UMR 9198)
Genome editing support at the I2BC: expertise with Cas9 and Tn5 tools
11h15 Albert Chesneau (Institut des Neurosciences Paris-Saclay, UMR 9197)
Genome Editing in Xenopus
11h30 Eric Batsché (Institut de Biologie Paris-Seine, UAR 3631)
CRISPR-Cas9–Mediated Epigenome Engineering to Explore Chromatin's Role in Alternative Splicing
12h15 Lunch break
Session 2 - CRISPR tools in plants and Xenopus model
Chairpersons: Reini Luco and Daan Noordermeer
13h15 Hervé Vaucheret (Institut Jean-Pierre Bourgin, INRAE, UMR 1318)
Heritable and non-heritable silencing unexpectedly triggered by CRISPR-Cas9 in plants
14h Pierre-François Perroud (Institut Jean-Pierre Bourgin, INRAE, UMR 1318)
Maturation of the Prime Editing tool in plants
14h30 Muriel Perron (Institut des Neurosciences Paris-Saclay, UMR 9197)
CRISPR technology in Xenopus enables retinal degeneration modeling and reveals key mechanisms driving regeneration
15h Coffee break
Session 3 - CRISPR application in medicine
Chairpersons: Laurie Menger and Jérôme Bouligand
15h30 Isabelle Bernard-Pierrot (Institut Curie, UMR 144)
Using PERTURB-seq to uncover core regulatory circuitry driving cell identity in luminal bladder cancer
16h Thomas Mercher (Institut Gustave Roussy, UMR 1170)
Precise modeling of a pediatric leukemia fusion oncogene starting from normal human cells
16h30 Laurie Menger (Institut Gustave Roussy, UMR 1015)
Systematic identification of targets for T cell resistance to host immune rejection
17h Andoni Echaniz Laguna (Hôpital Bicêtre, U 1195)
CRISPR-Cas9 In Vivo Gene Editing for Hereditary Transthyretin Amyloidosis
17h30 Conclusion
Clôture des inscriptions : mardi 3 juin 2025
Contact : gs.lsh@universite-paris-saclay.fr