[{"command":"insert","method":null,"selector":".course-modal-ajax-placeholder-959339","data":"\u003Cdiv class=\u0022container content-rte\u0022\u003E\n \u003Cdiv class=\u0022row\u0022\u003E\n \u003Cdiv class=\u0022box col-md-6 bg-primary text-white\u0022\u003E\n \u003Ch2 class=\u0022h1 text-left\u0022\u003E Genome Engineering\n\u003C\/h2\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EECTS :\n 3.5\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ESemestre calendaire :\n Semestre 1\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ED\u00e9tail du volume horaire\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan class=\u0022field__label h4 mt-5 \u0022\u003ECours magistraux :\u003C\/span\u003E\n \u003Cspan\u003E11\u003C\/span\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan class=\u0022field__label h4 mt-5 \u0022\u003ETravaux pratiques :\u003C\/span\u003E\n \u003Cspan\u003E9\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ELangue d\u0026#039;enseignement\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003EAnglais\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EEnseignement \u00e0 distance\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003Enon\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022box col-md-6\u0022\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EPr\u00e9requis\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003E\u003Cp\u003Enone\u003C\/p\u003E\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EProgramme \/ plan \/ contenus\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003E\u003Cp\u003EThis course will cover up-to-date techniques for DNA assembly (eg Gibson, Golden Gate, LIC, SLIC...), for site-directed DNA recombination (eg Cre-Lox, integrase, etc.), multiplex gene and genome editing (eg PACE, CRISPR, TALEN...), genome-scale engineering (eg genome reduction, genome synthesis, genome transplantation, MAGE, CAGE...) and explore the implications of continued advances toward the development of \ufb02exibly programmable \u201cchassis\u201d, novel biochemistries (eg non-canonical amino acids, XNA...), and safer engineering (eg genetic confinement, synthetic consortia...).\u003C\/p\u003E\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EObjectifs d\u0026#039;apprentissage\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003E\u003Cp\u003EGenome engineering technologies are revolutionising Life Sciences as they enable the rational design of synthetic biological systems. Recent advances in genome engineering have dramatically expanded our ability to engineer cells in a directed and combinatorial manner.\u0026nbsp;\u003C\/p\u003E\n\u003Cp\u003EAt the end of the course, students will be able to:\u003C\/p\u003E\n\u003Cp\u003E- Explain the principles of several genome engineering techniques\u003C\/p\u003E\n\u003Cp\u003E- Adapt genome engineering techniques to a given scientific issue\u003C\/p\u003E\n\u003Cp\u003E- Conceive orthogonal systems and explain their advantages and limitations\u003C\/p\u003E\n\u003Cp\u003E- Evaluate on-going research in the development of flexibly programmable chassis\u003C\/p\u003E\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EOrganisation g\u00e9n\u00e9rale et modalit\u00e9s p\u00e9dagogiques\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003E\u003Cp\u003EThe course module is organised in 14h of lectures and 6h of practical courses to introduce knowledge and methodological tools.\u003C\/p\u003E\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EBibliographie\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003E\u003Cp\u003ETextbook is not required in this course. We will use primary literature materials and power point slides. But, students are welcome to do some background reading using recommended reviews below:\u003C\/p\u003E\n\u003Cp\u003E- Esvelt KM, Wang HH. Genome-scale engineering for systems and synthetic biology. Mol Syst Biol 2013, 9:641.\u003C\/p\u003E\n\u003Cp\u003E- Annaluru N, et al. Total synthesis of a functional designer eukaryotic chromosome. Science 2014, 344:55-58.\u003C\/p\u003E\n\u003Cp\u003E- Kosuri S, Church GM. Large-scale de novo DNA synthesis: technologies and applications. Nat Methods 2014, 11:499-507.\u003C\/p\u003E\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ENature de l\u0026#039;\u00e9valuation\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003EEvaluation Continue non Int\u00e9grale\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n\u003C\/div\u003E\n","settings":null}]