[{"command":"insert","method":null,"selector":".course-modal-ajax-placeholder-958661","data":"\u003Cdiv class=\u0022container content-rte\u0022\u003E\n  \u003Cdiv class=\u0022row\u0022\u003E\n    \u003Cdiv class=\u0022box col-md-6 bg-primary text-white\u0022\u003E\n      \u003Ch2 class=\u0022h1 text-left\u0022\u003E  DNA Damage Repair in Normal and Cancer Cells\n\u003C\/h2\u003E\n                  \u003Cdiv class=\u0022field-spacing\u0022\u003E\n        \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EECTS :\n          2.5\n        \u003C\/div\u003E\n      \u003C\/div\u003E\n                  \u003Cdiv class=\u0022field-spacing\u0022\u003E\n        \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ESemestre calendaire :\n          Semestre 1\n        \u003C\/div\u003E\n      \u003C\/div\u003E\n            \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ED\u00e9tail du volume horaire\u003C\/div\u003E\n                                                    \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                          \u003Cspan class=\u0022field__label h4 mt-5 \u0022\u003ETravaux dirig\u00e9s :\u003C\/span\u003E\n                                      \u003Cspan\u003E23\u003C\/span\u003E\n                      \u003C\/div\u003E\n                                                            \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ELangue d\u0026#039;enseignement\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003EAnglais\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EEnseignement \u00e0 distance\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003Enon\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n      \u003C\/div\u003E\n    \u003Cdiv class=\u0022box col-md-6\u0022\u003E\n            \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EPr\u00e9requis\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cp\u003ELicence de biologie ou \u00e9quivalent\u003C\/p\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EProgramme \/ plan \/ contenus\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cp\u003EThe course consists of 22 hours of teaching (18 h lectures, 4 h tutorials), combining theoretical foundations with interactive sessions:\u003Cbr\u003E\nLectures (18 h)\u003Cbr\u003E\n\u2022 Introduction to genome stability and instability.\u003Cbr\u003E\n\u2022 DNA damage types and sources: endogenous and exogenous.\u003Cbr\u003E\n\u2022 DNA damage sensing and signaling pathways.\u003Cbr\u003E\n\u2022 DNA repair mechanisms: base excision repair, nucleotide excision repair, mismatch repair.\u003Cbr\u003E\n\u2022 DNA double-strand break repair: homologous recombination and non-homologous end joining.\u003Cbr\u003E\n\u2022 DNA replication and recombination stress.\u003Cbr\u003E\n\u2022 Epigenome and chromatin dynamics in DNA repair.\u003Cbr\u003E\n\u2022 Telomere biology and genome stability.\u003Cbr\u003E\n\u2022 Cell cycle checkpoints and coordination with DNA repair.\u003Cbr\u003E\n\u2022 Cell fate decisions after DNA damage: apoptosis, senescence, survival.\u003Cbr\u003E\n\u2022 Deregulation of DNA damage response in cancer and therapeutic implications.\u003Cbr\u003E\n\u2022 Targeting genome instability: current and emerging cancer therapies.\u003Cbr\u003E\nTutorials (4 h)\u003Cbr\u003E\n\u2022 Critical analysis of research articles related to DNA damage response.\u003Cbr\u003E\n\u2022 Group discussions of experimental data and methodologies used in the field.\u003Cbr\u003E\n\u2022 Preparation for the final written exam through exercises and guided data interpretation.\u003C\/p\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EObjectifs d\u0026#039;apprentissage\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cp\u003EAt the end of the course, students should be able to:\u003Cbr\u003E\n\u2022 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Describe and explain the molecular mechanisms of DNA damage detection, signaling, and repair.\u003Cbr\u003E\n\u2022 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Understand the integration of DNA damage response pathways with cell cycle regulation, replication stress management, and cell fate determination (apoptosis, senescence, survival).\u003Cbr\u003E\n\u2022 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Analyze and compare the mechanisms of genome maintenance in normal cells versus their deregulation in cancer cells.\u003Cbr\u003E\n\u2022 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Evaluate how genomic instability, telomere dysfunction, and epigenome alterations contribute to tumor initiation and progression.\u003Cbr\u003E\n\u2022 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Discuss current therapeutic strategies targeting genome instability in cancer and their rationale.\u003Cbr\u003E\n\u2022 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Develop critical thinking through discussion of primary literature and exposure to ongoing research methodologies.\u003C\/p\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EOrganisation g\u00e9n\u00e9rale et modalit\u00e9s p\u00e9dagogiques\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cp\u003EThis course provides students with a detailed understanding of the cellular and molecular mechanisms that ensure the maintenance of genome integrity and explores how their deregulation drives cancer development. It bridges fundamental concepts of genome biology with the physiopathology of cancer and highlights the translational aspects of current research. Through lectures delivered by internationally recognized experts, the course introduces the main pathways of DNA repair, replication, recombination, and cell cycle control, as well as their integration in genome stability and tumorigenesis.\u003C\/p\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EModalit\u00e9s p\u00e9dagogiques particuli\u00e8res\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cp\u003EThe UE is taught entirely in English and combines lectures (18 h) and tutorials (4 h) in an interactive format. Lectures are delivered by a multidisciplinary team of experts from Universit\u00e9 Paris-Saclay, Institut Curie, Institut Gustave Roussy, IRCM, and I2BC, ensuring that students are exposed to state-of-the-art research in DNA damage response and cancer biology.\u003Cbr\u003E\nStudents are encouraged to actively participate through questions, discussions, and analysis of selected scientific publications. Tutorials focus on data interpretation and critical thinking, thereby reinforcing the concepts introduced during lectures.\u003Cbr\u003E\nAssessment\u003Cbr\u003E\n\u2022 First session (MC2C):\u0026nbsp;\u003Cbr\u003E\nMultiple Choice Questionnaire :40% of the final grade\u003Cbr\u003E\nWritten examination (2h) :60% of the final grade\u003Cbr\u003E\n\u2022 Second chance (MC2C): 2-hour written exam or oral examination.\u003C\/p\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n                        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ENature de l\u0026#039;\u00e9valuation\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003EEvaluation Continue non Int\u00e9grale\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n      \u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n","settings":null}]