[{"command":"insert","method":null,"selector":".course-modal-ajax-placeholder-950685","data":"\u003Cdiv class=\u0022container content-rte\u0022\u003E\n  \u003Cdiv class=\u0022row\u0022\u003E\n    \u003Cdiv class=\u0022box col-md-6 bg-primary text-white\u0022\u003E\n      \u003Ch2 class=\u0022h1 text-left\u0022\u003E  Pharmacologie mol\u00e9culaire\n\u003C\/h2\u003E\n                  \u003Cdiv class=\u0022field-spacing\u0022\u003E\n        \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EECTS :\n          3\n        \u003C\/div\u003E\n      \u003C\/div\u003E\n                  \u003Cdiv class=\u0022field-spacing\u0022\u003E\n        \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ESemestre calendaire :\n          Semestre 1\n        \u003C\/div\u003E\n      \u003C\/div\u003E\n            \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ED\u00e9tail du volume horaire\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                          \u003Cspan class=\u0022field__label h4 mt-5 \u0022\u003ECours magistraux :\u003C\/span\u003E\n                                      \u003Cspan\u003E8\u003C\/span\u003E\n                      \u003C\/div\u003E\n                                              \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                          \u003Cspan class=\u0022field__label h4 mt-5 \u0022\u003ETravaux dirig\u00e9s :\u003C\/span\u003E\n                                      \u003Cspan\u003E12\u003C\/span\u003E\n                      \u003C\/div\u003E\n                                                            \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                          \u003Cspan class=\u0022field__label h4 mt-5 \u0022\u003EApprentissage autonome :\u003C\/span\u003E\n                                      \u003Cspan\u003E4\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ELangue d\u0026#039;enseignement\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003EFran\u00e7ais\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EEnseignement \u00e0 distance\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003Enon\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n      \u003C\/div\u003E\n    \u003Cdiv class=\u0022box col-md-6\u0022\u003E\n            \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EPr\u00e9requis\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cp\u003EConnaissances des notions de pharmacologie et des principes de l\u2019\u00e9valuation pharmacologique des m\u00e9dicaments\u0026nbsp;:\u0026nbsp;\u003C\/p\u003E\n\u003Cul\u003E\n\u003Cli\u003EMots cl\u00e9s\u0026nbsp;: cible pharmacologique, r\u00e9cepteur, enzyme, canal ionique, affinit\u00e9, activit\u00e9, agoniste, antagoniste, s\u00e9lectivit\u00e9, puissance, efficacit\u00e9.\u0026nbsp;\u003C\/li\u003E\n\u003Cli\u003ELes param\u00e8tres associ\u00e9s et les m\u00e9thodologies classiques permettant de les d\u00e9terminer.\u003C\/li\u003E\n\u003Cli\u003ELa biologie cellulaire des principales voies de couplage des r\u00e9cepteurs membranaires\u0026nbsp;: r\u00e9cepteurs coupl\u00e9s \u00e0 des prot\u00e9ine G, \u00e0 activit\u00e9 enzymatique, ionotropiques ou nucl\u00e9aires.\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EProgramme \/ plan \/ contenus\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cul\u003E\n\u003Cli\u003ERappels sur la pharmacologie mol\u00e9culaire\u0026nbsp;: ma\u00eetriser les notions cl\u00e9s, les param\u00e8tres\u003C\/li\u003E\n\u003Cli\u003EPerfectionnement en Pharmacom\u00e9trie\u0026nbsp;: cas de caract\u00e9risations complexes (modulateurs allost\u00e9riques, agonistes inverses, agonistes biais\u00e9s)\u003C\/li\u003E\n\u003Cli\u003EDiversit\u00e9 des voies de transduction du signal\u0026nbsp;: voies \u00ab\u0026nbsp;canoniques\u0026nbsp;\u00bb et \u00ab\u0026nbsp;non-canoniques\u0026nbsp;\u00bb, et les grandes fonctions biologiques associ\u00e9es.\u003C\/li\u003E\n\u003Cli\u003EM\u00e9thodologies classiques de caract\u00e9risation pharmacologique et leur perfectionnement\u003C\/li\u003E\n\u003Cli\u003EExemples d\u2019autres m\u00e9thodologies et leurs applications (Technologies Kinexa, Biacore, biosenseurs FRET, BRET, cristallographie, intelligence artificielle)\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EObjectifs d\u0026#039;apprentissage\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cul\u003E\n\u003Cli\u003EIdentifier et int\u00e9grer les diff\u00e9rentes donn\u00e9es pharmacologiques caract\u00e9risant l\u2019action de entit\u00e9s mol\u00e9culaires sur leur cible.\u003C\/li\u003E\n\u003Cli\u003EInterpr\u00e9ter les r\u00e9sultats d\u2019exp\u00e9riences visant \u00e0 mettre en \u00e9vidence ces propri\u00e9t\u00e9s par des m\u00e9thodologies classiques ou innovantes.\u003C\/li\u003E\n\u003Cli\u003ECommuniquer clairement et pr\u00e9cis\u00e9ment les donn\u00e9es pharmacologiques exp\u00e9rimentales.\u003C\/li\u003E\n\u003Cli\u003EMettre en perspective les propri\u00e9t\u00e9s mol\u00e9culaires des agents pharmacologiques en termes d\u2019utilisation th\u00e9rapeutique.\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EOrganisation g\u00e9n\u00e9rale et modalit\u00e9s p\u00e9dagogiques\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cul\u003E\n\u003Cli\u003EL\u2019UE comprend 8h de cours magistraux (CM)\u003C\/li\u003E\n\u003C\/ul\u003E\n\u003Cp\u003E- des cours magistraux dispens\u00e9s par des enseignants de pharmacologie\u003C\/p\u003E\n\u003Cp\u003E- des interventions de chercheurs experts utilisant les m\u00e9thodologies de pharmacologie mol\u00e9culaire pour leurs travaux.\u003C\/p\u003E\n\u003Cul\u003E\n\u003Cli\u003EDes travaux dirig\u00e9s intensifs (12h) permettront de forger les capacit\u00e9s d\u2019analyse \u00e0 partir d\u2019\u00e9tudes de cas de complexit\u00e9 croissante. Des s\u00e9ances auront lieu en salle informatique afin de profiter du logiciel Graphpad Prism dans l\u2019analyse des donn\u00e9es et l\u2019\u00e9laboration de graphiques.\u003C\/li\u003E\n\u003Cli\u003ETravail en autonomie (4h) d\u2019\u00e9laboration de compte-rendu\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n                        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EBibliographie\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cp\u003E1.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Hill, S.J. G-protein-coupled receptors: past, present and future. \u003Cem\u003EBr J Pharmacol\u003C\/em\u003E \u003Cstrong\u003E2006\u003C\/strong\u003E, \u003Cem\u003E147 Suppl 1\u003C\/em\u003E, S27-37, doi:10.1038\/sj.bjp.0706455.\u003C\/p\u003E\n\u003Cp\u003E2.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Pearce, A.; Redfern-Nichols, T.; Wills, E.; Rosa, M.; Manulak, I.; Sisk, C.; Huang, X.; Atakpa-Adaji, P.; Prole, D.L.; Ladds, G. Quantitative approaches for studying G protein-coupled receptor signalling and pharmacology. \u003Cem\u003EJ Cell Sci\u003C\/em\u003E \u003Cstrong\u003E2025\u003C\/strong\u003E, \u003Cem\u003E138\u003C\/em\u003E, doi:10.1242\/jcs.263434.\u003C\/p\u003E\n\u003Cp\u003E3.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Gregory, K.J.; Sexton, P.M.; Christopoulos, A. Overview of receptor allosterism. \u003Cem\u003ECurr Protoc Pharmacol\u003C\/em\u003E \u003Cstrong\u003E2010\u003C\/strong\u003E, \u003Cem\u003EChapter 1\u003C\/em\u003E, Unit 1 21, doi:10.1002\/0471141755.ph0121s51.\u003C\/p\u003E\n\u003Cp\u003E4.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Rang, H.P.R., J.M.; Flower R.J.; Henderson, G. , (Ed.) \u003Cem\u003ERang and Dale\u0027s pharmacology\u003C\/em\u003E. Eighth edition ed.; [United Kingdom] : Elsevier Churchill Livingstone, [2016]: 2016.\u003C\/p\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ENature de l\u0026#039;\u00e9valuation\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003EEvaluation Continue non Int\u00e9grale\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n      \u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n","settings":null}]