Stabilité génétique et oncogenèse

Présentation du laboratoire

Le laboratoire Stabilité génétique et oncogenèse travaille sur la réponse cellulaire et moléculaire à l'altération de l'ADN. Ces altérations peuvent être responsables d'anomalies du développement, au vieillissement prématuré, à une prédisposition de l'apparition de cancer ou encore une mort cellulaire. Les recherches portent donc sur la compréhension des mécanismes de réparation de l'ADN de cellulaire humaines et murines à partir d'analyses biochimiques, génétiques, moléculaires et cellulaires. Ces travaux ont déjà permis la création de nombreuses innovations protégées par 4 brevets.

Les 20 dernières publications

Titre Auteurs Date de publication Source
Inherited transmission of the CSF3R T618I mutational hotspot in familial chronic neutrophilic leukemia Christophe Willekens, S. de Botton 26/12/2019 Blood
Primary central nervous system lymphoma: Initial features, outcome, and late effects in 75 children and adolescents Charlotte Rigaud 23/12/2019 Blood Advances
XPD/ERCC2 mutations interfere in cellular responses to oxidative stress Alain Sarasin 19/12/2019 Mutagenesis
Efficacy and safety of dabrafenib in pediatric patients with BRAF V600 mutation–positive relapsed or refractory low-grade glioma: Results from a phase I/IIa study Birgit Geoerger 15/12/2019 Clinical Cancer Research
Analysis of biomarkers and association with clinical outcomes in patients with differentiated thyroid cancer: Subanalysis of the sorafenib phase III DECISION trial Martin Schlumbeger 15/12/2019 Clinical Cancer Research
A phase I and pharmacokinetic study of oral dabrafenib in children and adolescent patients with recurrent or refractory BRAF V600 mutation–positive solid tumors Birgit Geoerger 15/12/2019 Clinical Cancer Research
Impact of breast cancer molecular subtypes on the incidence, kinetics and prognosis of central nervous system metastases in a large multicentre real-life cohort Suzette Delaloge, G. Louvel 10/12/2019 British Journal of Cancer
Immune biomarkers in thymic epithelial tumors: Expression patterns, prognostic value and comparison of diagnostic tests for PD-L1 Maria Virginia Bluthgen, Benjamin Besse 04/12/2019 Biomarker Research
Worsening and newly diagnosed paraneoplastic syndromes following anti-PD-1 or anti-PD-L1 immunotherapies, a descriptive study Olivier Lambotte, Aurélien Marabelle, Jean Marie Michot, ... 03/12/2019 Journal for ImmunoTherapy of Cancer
Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort Marina Kvaskoff, Agnès Fournier, Patrick Arveux 02/12/2019 BMC Medicine
Phosphorylation of CENP-A on serine 7 does not control centromere function Viviana Barra 01/12/2019 Nature communications
BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation Sophie Postel-Vinay 01/12/2019 Nature Communications
CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary Alexandra Leary, Aurélie Auguste 01/12/2019 Nature Communications
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species David Pierre Enot, Guido Kroemer, Sylvère Durand, ... 01/12/2019 Nature Communications
Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner Magali Lacroix-Triki 01/12/2019 Nature Communications
The complexity of tumor shape, spiculatedness, correlates with tumor radiomic shape features Éric Deutsch, Elaine Johanna Limkin, Sylvain Reuze, ... 01/12/2019 Scientific reports
Crizotinib-induced immunogenic cell death in non-small cell lung cancer Erika Vacchelli, Véronique Minard-Colin, Sylvère Durand, ... 01/12/2019 Nature Communications
Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages Eric Solary, Nathalie Droin, M'boyba Khadija Diop, ... 01/12/2019 Nature Communications
SNAI1 recruits HDAC1 to suppress SNAI2 transcription during epithelial to mesenchymal transition Jean Paul Thiery 01/12/2019 Scientific Reports
Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein Éric Deutsch, Frédérique Mégnin-Chanet 01/12/2019 Scientific Reports