Signalisation et Physiopathologie Cardiovasculaire

Présentation du laboratoire

Le SPC s'articule autour de trois équipes développant des thèmes complémentaires sur des modèles animaux et cellulaires pour étudier les mécanismes impliqués dans la fonction cardiaque au travers des récepteurs membranaires, des canaux ioniques, des nucléotides cycliques, du métabolisme énergétique, du calcium, et de compartiments intracellulaires.
L'unité a vocation à élucider des nouveaux mécanismes physiopathologiques et identifier de nouvelles cibles thérapeutiques dans les traitements de l'insuffisance cardiaque et des arythmies.Elle est en charge de projets novateurs au sein du LabEx LERMIT en partenariat avec les autres laboratoires de l'IPSIT.

Les 20 dernières publications

Titre Auteurs Date de publication Source
BET bromodomain inhibitors and pulmonary arterial hypertension: Take care of the heart Jérôme Piquereau 01/11/2019 American Journal of Respiratory and Critical Care Medicine
Disturbed fatty acid oxidation, endoplasmic reticulum stress, and apoptosis in left ventricle of patients with type 2 diabetes Christophe Lemaire, Mélanie Gressette 01/10/2019 Diabetes
Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction Aziz Guellich, Delphine Mika, Grégoire Vandecasteele, ... 01/10/2019 Cardiovascular Research
Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension Boris Manoury, Valérie Domergue 13/09/2019 Circulation research
The oyster Crassostrea gigas, a new model against cancer Catherine Brenner 01/01/2019 Medecine sciences : M/S
Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension Jessica Sabourin, Ana M. Gomez, Boris Manoury, ... 12/02/2019 Circulation
Endoplasmic reticulum stress induces cardiac dysfunction through architectural modifications and alteration of mitochondrial function in cardiomyocytes Christophe Lemaire, Renée Ventura-Clapier, Anne Garnier, ... 01/02/2019 Cardiovascular research
Is Epac1 a good therapeutic strategy against cardiac remodelling? Laetitia Pereira 01/01/2019 Cardiovascular research
Ion Channels in Pulmonary Hypertension: A Therapeutic Interest? Jessica Sabourin 14/10/2018 International journal of molecular sciences
Heart rate: when macrophages hit the note Grégoire Vandecasteele 01/10/2018 Medecine sciences : M/S
Arrhythmias precede cardiomyopathy and remodeling of Ca<sup>2+</sup> handling proteins in a novel model of long QT syndrome Ana M. Gomez, J. P. Benitah, Linwei Li 01/10/2018 Journal of Molecular and Cellular Cardiology
Anticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death article Catherine Brenner 01/07/2018 Cell Death and Disease
Multimed: An integrated, multi-application platform for the real-time recording and sub-millisecond processing of biosignals Romain Perrier 01/07/2018 Sensors (Switzerland)
QSOX1, a novel actor of cardiac protection upon acute stress in mice Ana M. Gomez, Marine Gandon 01/06/2018 Journal of Molecular and Cellular Cardiology
Ca<sup>2+</sup>handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy Jessica Sabourin, Ana M. Gomez, J. P. Benitah 01/05/2018 Journal of Molecular and Cellular Cardiology
Specific Activation of the Alternative Cardiac Promoter of Cacna1c by the Mineralocorticoid Receptor Jessica Sabourin, Florence Lefebvre, Patrick Lechêne, ... 30/03/2018 Circulation Research
Nicotinamide riboside preserves cardiac function in a mouse model of dilated cardiomyopathy Boris Manoury, Mathias Mericskay, Anne Garnier, ... 01/01/2018 Circulation
The Oxygen Paradox, the French Paradox, and age-related diseases Mathias Mericskay 01/12/2017 GeroScience
T-type Ca<sup>2 +</sup> channels elicit pro-proliferative and anti-apoptotic responses through impaired PP2A/Akt1 signaling in PASMCs from patients with pulmonary arterial hypertension Jessica Sabourin 01/10/2017 Biochimica et Biophysica Acta - Molecular Cell Research
Antihypertensive and vasodilator effects of methanolic extract of Inula viscosa: Biological evaluation and POM analysis of cynarin, chlorogenic acid as potential hypertensive Rodolphe Fischmeister, Véronique Leblais 01/09/2017 Biomedicine and Pharmacotherapy