Service de Chimie Bio-organique et de Marquage - DRF/JOLIOT/DMTS

Présentation du laboratoire

Le Service de Chimie Bioorganique et de Marquage (SCBM, département Médicament et Technologie pour la Santé, Institut Joliot) regroupe une cinquantaine de personnes dont une vingtaine de doctorants et post-doctorants. Les recherches se concentrent autour des thématiques suivantes : Marquage isotopique, Molécules bioactives, Nouveaux outils pour la biologie, Nanosciences.
L'ensemble de ces recherches fait appel à un savoir-faire commun à tous les chercheurs du service : la chimie organique. Ces recherches nécessitent, la plupart du temps, une approche multidisciplinaire réalisée en étroite collaboration avec des partenaires académiques ou industriels.

Les 20 dernières publications

Titre Auteurs Date de publication Source
Accelerated Discovery in Photocatalysis by a Combined Screening Approach Involving MS Tags Frédéric Taran, Davide Audisio, Elodie Decuypère, ... 06/12/2019 Organic Letters
Toxicological assessment of ITER-like tungsten nanoparticles using an in Vitro 3D human airway epithelium model Bernard Rousseau, Isabelle George 01/10/2019 Nanomaterials
Tuning the catalytic activity and selectivity of water-soluble bimetallic RuPt nanoparticles by modifying their surface metal distribution Grégory Pieters 21/09/2019 Nanoscale
In vitro analysis of the effects of ITER-like tungsten nanoparticles: Cytotoxicity and epigenotoxicity in BEAS-2B cells Bernard Rousseau, Sébastien Garcia-Argote 01/09/2019 Nanomaterials
Glucocorticoids delay RAF-induced senescence promoted by EGR1 Jean Christophe Cintrat 22/08/2019 Journal of cell science
DABMA: A Derivative of ABMA with improved broad-spectrum inhibitory activity of toxins and viruses Jean Christophe Cintrat, Valérie Pons, Romain Noël 08/08/2019 ACS Medicinal Chemistry Letters
Design of model tokamak particles for future toxicity studies: Morphology and physical characterization Bernard Rousseau, Jacques Chêne, Sébastien Garcia-Argote, ... 01/08/2019 Fusion Engineering and Design
Spermine-NBD as fluorescent probe for studies of the polyamine transport system in Leishmania donovani Jean Christophe Cintrat 15/07/2019 Bioorganic and Medicinal Chemistry Letters
Triphenylbismuth Dichloride-Mediated Conversion of Thioamides to Nitriles Eric Doris, Edmond Gravel, Elumalai Gopi 07/07/2019 European Journal of Organic Chemistry
Aptamer-decorated polydiacetylene micelles with improved targeting of cancer cells Eric Doris, Edmond Gravel, Anaëlle Doerflinger 30/06/2019 International Journal of Pharmaceutics
Bimodal Detection of Proteins by <sup>129</sup> Xe NMR and Fluorescence Spectroscopy Gaëlle Milanole 03/06/2019 ChemBioChem
Dodecyl creatine ester-loaded nanoemulsion as a promising therapy for creatine transporter deficiency Frédéric Taran, Sophie Dezard 01/06/2019 Nanomedicine
Tumor targeted micellar nanocarriers assembled from epipodophyllotoxin-based amphiphiles Eric Doris, Edmond Gravel, Dinh Vu Nguyen, ... 21/05/2019 Nanoscale
Controlled Release of a Micelle Payload via Sequential Enzymatic and Bioorthogonal Reactions in Living Systems Eric Doris, Edmond Gravel, Frédéric Taran, ... 06/05/2019 Angewandte Chemie - International Edition
Using hydrogen isotope incorporation as a tool to unravel the surfaces of hydrogen-treated nanodiamonds Sébastien Garcia-Argote, Grégory Pieters, Emilie Nehlig, ... 28/04/2019 Nanoscale
Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen-Isotope Exchange Sébastien Garcia-Argote, David Alexandre Buisson, Grégory Pieters, ... 01/04/2019 Angewandte Chemie - International Edition
Squalene-Adenosine Nanoparticles: Ligands of Adenosine Receptors or Adenosine Prodrug? Sébastien Garcia-Argote, Grégory Pieters 01/04/2019 The Journal of pharmacology and experimental therapeutics
Sydnone-based turn-on fluorogenic probes for no-wash protein labeling and in-cell imaging Frédéric Taran, Davide Audisio, A. Sallustrau, ... 01/01/2019 Chemical Communications
Catalytic Dehydrosulfurization of Thioamides to Nitriles by Gold Nanoparticles Supported on Carbon Nanotubes Eric Doris, Edmond Gravel, Elumalai Gopi 05/12/2019 ChemCatChem
Catalytic Decarboxylation/Carboxylation Platform for Accessing Isotopically Labeled Carboxylic Acids Olivier Loreau, Davide Audisio, A. Sallustrau 05/07/2019 ACS Catalysis