Physiopathogénèse et traitement des maladies du Foie

Présentation du laboratoire

L'unité Physiopathogénèse et traitement des maladies du foie a pour but de développer la recherche translationnelle dans les pathologies hépatiques autour de deux thématiques majeures : les cancers hépatiques d'une part, et les hépatites (dont virales) d'autre part avec la volonté de proposer des thérapies innovantes.
Elle est composée de chercheurs et de cliniciens renommés ainsi que d'ATR qui permettent de faire le pont entre le laboratoire et le lit du malade. L'unité est très impliquée dans les essais cliniques internationaux pour la prise en charge des carcinomes hépatiques et des hépatites. En outre, elle profite des équipements mis à disposition par le plateau technique de l'Institut Lwoff et du réseau d'experts du DHU Hepatinov.

Les 20 dernières publications

Titre Auteurs Date de publication Source
The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression François Le Naour 01/12/2019 Nature Communications
FABP4 and MMP9 levels identified as predictive factors for poor prognosis in patients with nonalcoholic fatty liver using data mining approaches and gene expression analysis Catherine Guettier, D. Samuel, Audrey Coilly, ... 01/12/2019 Scientific Reports
Hepatitis B virus replicating in hepatocellular carcinoma encodes HBx variants with preserved ability to antagonize restriction by Smc5/6 M. A. Buendia, Cyrille Feray, Guillaume Fallot, ... 01/12/2019 Antiviral Research
La publication au JO de nouveaux règlements européens sur les dispositifs médicaux pourrait-elle changer la pratique du diagnostic oncogénétique en France ? Antoinette Lemoine, P. Pham, Nelly Bosselut, ... 01/10/2019 Annales de biologie clinique
Evaluation of Readministration of Immune Checkpoint Inhibitors after Immune-Related Adverse Events in Patients with Cancer Michael Collins 01/09/2019 JAMA Oncology
Prognostic Value and Prediction of Extratumoral Microvascular Invasion for Hepatocellular Carcinoma Marc Antoine Allard, R. Adam, D. Samuel, ... 15/08/2019 Annals of Surgical Oncology
Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection Jérôme Caron, Anne Weber, E. Luce, ... 29/07/2019 Stem Cell Research and Therapy
Management of Fulminant Hepatitis B D. Samuel, Philippe Ichai 01/07/2019 Current Infectious Disease Reports
Arterial Lactate Concentration at the End of Liver Transplantation Is an Early Predictor of Primary Graft Dysfunction Denis Castaing, Eric Vibert, Daniel Cherqui, ... 01/07/2019 Annals of surgery
Predictive model for microvascular invasion of hepatocellular carcinoma among candidates for either hepatic resection or liver transplantation Marc Antoine Allard, R. Adam, D. Samuel, ... 01/06/2019 Surgery (United States)
Hepatitis B virus reactivation in transplant patients treated for hepatitis C recurrence: Prophylaxis makes the difference Lina Mouna, Anne Marie Roque-Afonso, Jean Charles Duclos-Vallée, ... 01/06/2019 Journal of Hepatology
Tetraspanin CD82 organizes dectin-1 into signaling domains to mediate cellular responses to candida albicans François Le Naour 01/06/2019 Journal of Immunology
Insight into microtubule nucleation from tubulin-capping proteins Christian Poüs, Antoine Pilon 14/05/2019 Proceedings of the National Academy of Sciences of the United States of America
Early mitochondrial fragmentation is a potential in vitro biomarker of environmental stress Christian Poüs, Daniel Perdiz 01/05/2019 Chemosphere
Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study D. Samuel 06/04/2019 The Lancet
Safety and efficacy of the combination simeprevir-sofosbuvir in HCV genotype 1- and 4-mono-infected patients from the French ANRS CO22 hepather cohort D. Samuel 02/04/2019 BMC Infectious Diseases
Management of acute kidney injury in cirrhosis Faouzi Saliba 01/04/2019 Hepato-Gastro et Oncologie Digestive
Septin 9 has Two Polybasic Domains Critical to Septin Filament Assembly and Golgi Integrity Christian Poüs, D. Samuel, Nassima Benzoubir, ... 29/03/2019 Food Science and Human Wellness
Determination of rubella virus-specific humoral and cell-mediated immunity in pregnant women with negative or equivocal rubella-specific IgG in routine screening Christelle Vauloup-Fellous 01/03/2019 Journal of Clinical Virology
Reply to: “Acute liver failure due to immune-mediated hepatitis successfully managed with plasma exchange: New settings call for new treatment strategies?” Eleonora De Martin, D. Samuel, Barbara Papouin 01/03/2019 Journal of Hepatology