Laboratoire de Génétique et de biologie cellulaire

Présentation du laboratoire

Les principaux thèmes de recherche développés au LGBC concernent d'une part les modalités et la régulation des processus de mort cellulaire, en particulier au niveau mitochondrial, et d'autre part, les mécanismes compensatoires impliqués dans le maintien de l'homéostasie tissulaire à la suite de stress impliquant la mitochondrie ou le réticulum endoplasmique. Pour cela, nous utilisons des modèles cellulaires de mammifères et les drosophiles..

En parallèle, nous menons des projets en collaboration qui utilisent notamment des modèles mimant des pathologies chez la drosophile.

Les 20 dernières publications

Titre Auteurs Date de publication Source
HLA-B27 alters BMP/TGFβ signalling in Drosophila, revealing putative pathogenic mechanism for spondyloarthritis I. Guenal, S. Gaumer, A. Rincheval-Arnold, ... 01/12/2019 Annals of the Rheumatic Diseases
Investigating the effects of different natural molecules on the structure and oligomerization propensity of hen egg-white lysozyme Ali Châari 01/08/2019 International Journal of Biological Macromolecules
The endoplasmic reticulum unfolded protein response varies depending on the affected region of the tissue but independently from the source of stress Bernard Mignotte, S. Szuplewski, S. Gaumer, ... 01/07/2019 Cell Stress and Chaperones
High-resolution transcription maps reveal the widespread impact of roadblock termination in yeast Jessie Colin 15/02/2018 EMBO Journal
FGF1 induces resistance to chemotherapy in ovarian granulosa tumor cells through regulation of p53 mitochondrial localization Sevasti Manousakidi, Bernard Mignotte, Sylvina Bouleau, ... 01/02/2018 Oncogenesis
Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity Delphine Sitterlin 01/10/2017 Journal of Hepatology
FGF1 protects neuroblastoma SH-SY5Y cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation F. Montazer-Torbati, Bernard Mignotte, Flore Renaud, ... 31/08/2017 Cell death & disease
Clone war: tumour-suppressive cell competition Bernard Mignotte 01/06/2017 Medecine/Sciences
Evolutionary conservation of Notch signaling inhibition by TMEM131L overexpression Bernard Mignotte, S. Szuplewski, I. Guenal 13/05/2017 Biochemical and Biophysical Research Communications
The comeback of mitochondria in Drosophila apoptosis Bernard Mignotte, I. Guenal, Amandine Clavier, ... 01/05/2016 Medecine/Sciences
Apoptosis in Drosophila: Which role for mitochondria? Bernard Mignotte, I. Guenal, Jessie Colin, ... 01/03/2016 Apoptosis
FGF1 C-terminal domain and phosphorylation regulate intracrine FGF1 signaling for its neurotrophic and anti-apoptotic activities Bernard Mignotte, Sylvina Bouleau, Flore Renaud, ... 04/02/2016 Cell Death and Disease
Two different specific JNK activators are required to trigger apoptosis or compensatory proliferation in response to Rbf1 in Drosophila Adrienne Baillet, Bernard Mignotte, I. Guenal, ... 17/01/2016 Cell Cycle
A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1 Frédéric Canal 29/12/2015 BMC Cancer
Insights into kinetics of agitation-induced aggregation of hen lysozyme under heat and acidic conditions from various spectroscopic methods Ali Châari 01/11/2015 PLoS ONE
Quantification of Ataxin-3 and Ataxin-7 aggregates formed in vivo in Drosophila reveals a threshold of aggregated polyglutamine proteins associated with cellular toxicity Bernard Mignotte, S. Gaumer, Gérald Vinatier, ... 04/09/2015 Biochemical and Biophysical Research Communications
Inactivation of p53 is sufficient to induce development of pulmonary hypertension in rats Vincent Rincheval, Bernard Mignotte 29/06/2015 PLoS ONE
Daytime CLOCK Dephosphorylation Is Controlled by STRIPAK Complexes in Drosophila Sylvina Bouleau 26/05/2015 Cell Reports
p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies S. Gaumer 16/01/2015 Journal of Biological Chemistry
The Drosophila retinoblastoma protein, Rbf1, induces a Debcl- and Drp1-dependent mitochondrial apoptosis Bernard Mignotte, V. Ruby, I. Guenal, ... 01/01/2015 Journal of Cell Science