Institut des Cellules souches pour le traitement et l'étude des maladies monogéniques

Présentation du laboratoire

L'Institut des cellules Souches pour le Traitement et l'Etude des maladies Monogéniques (I-Stem) est un centre de R&D dédié à l'élaboration de traitements fondés sur les potentiels offerts par les cellules souches pluripotentes et applicable aux maladies rares d'origine génétique. Son domaine d'activité s'étend depuis la recherche fondamentale de mécanismes pathologiques jusqu'au transfert de nouvelles thérapies à la recherche clinique. Les grandes indications pathologiques étudiées actuellement sont relatives aux maladies du muscle, des motoneurones et de la peau.

Les 20 dernières publications

Titre Auteurs Date de publication Source
Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins Christian Pinset, Emmanuelle Massourides, Virginie Mournetas 01/12/2019 Nature Communications
Altered spinogenesis in iPSC-derived cortical neurons from patients with autism carrying de novo SHANK3 mutations Alexandra Benchoua, Aurélie Poulet 01/12/2019 Scientific Reports
Identification of thiostrepton as a pharmacological approach to rescue misfolded alpha-sarcoglycan mutant proteins from degradation Isabelle Richard, Nathalie Bourg, Sara F. Henriques, ... 01/12/2019 Scientific Reports
Automation of human pluripotent stem cell differentiation toward retinal pigment epithelial cells for large-scale productions Léa Lesueur, Lise Morizur, Christelle Monville, ... 01/12/2019 Scientific Reports
MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates Anselme L. Perrier, Aurore Bugi, Marie Michael 01/12/2019 Nature Communications
Induced pluripotent stem cells-derived neurons from patients with Friedreich ataxia exhibit differential sensitivity to resveratrol and nicotinamide Jacqueline Gide, Cécile Martinat, Marc Peschanski, ... 01/12/2019 Scientific Reports
KLF4 inhibition promotes the expansion of keratinocyte precursors from adult human skin and of embryonic-stem-cell-derived keratinocytes Gilles Lemaître 01/12/2019 Nature Biomedical Engineering
Characterizing the interplay between gene nucleotide composition bias and splicing Hélène Polvèche 29/11/2019 Genome Biology
The abietane diterpene taxodione contributes to the antioxidant activity of rosemary by-product in muscle tissue Xavier Nissan, Alessandra Lo Cicero 01/11/2019 Journal of Functional Foods
Longitudinal characterization of cognitive and motor deficits in an excitotoxic lesion model of striatal dysfunction in non-human primates Anselme L. Perrier 01/10/2019 Neurobiology of Disease
CTIP2-Regulated Reduction in PKA-Dependent DARPP32 Phosphorylation in Human Medium Spiny Neurons: Implications for Huntington Disease Anselme L. Perrier, Morgane Louessard 10/09/2019 Stem Cell Reports
Photoreceptor cell replacement in macular degeneration and retinitis pigmentosa: A pluripotent stem cell-based approach Karim Ben M'Barek 01/07/2019 Progress in Retinal and Eye Research
Interplay between coding and exonic splicing regulatory sequences Hélène Polvèche 01/05/2019 Genome Research
Distinctive Krebs cycle remodeling in iPSC-derived neural and mesenchymal stem cells Laetitia Aubry 09/04/2019 Biochemical and Biophysical Research Communications
Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network Anselme L. Perrier, Simona Gribaudo, Patricia Lino 12/02/2019 Stem Cell Reports
Comprehensive human stem cell differentiation in a 2D and 3D mode to cardiomyocytes for long-term cultivation and multiparametric monitoring on a multimodal microelectrode array setup Mathilde Girard 01/02/2019 Biosensors and Bioelectronics
Reply: Could weight loss contribute to the improved mobility with metformin in patients with myotonic dystrophy type 1? Marc Peschanski 01/02/2019 Brain
Pluripotent Stem Cell-Based Drug Screening Reveals Cardiac Glycosides as Modulators of Myotonic Dystrophy Type 1 Léa Lesueur, Sandrine Baghdoyan, Jacqueline Gide, ... 25/01/2019 Food Science and Human Wellness
Cell therapy for retinal dystrophies: From cell suspension formulation to complex retinal tissue bioengineering Christelle Monville, Karim Ben M’Barek 01/01/2019 Stem Cells International
Cathepsin B pH-Dependent Activity Is Involved in Lysosomal Dysregulation in Atrophic Age-Related Macular Degeneration Christelle Monville, Alexandra Plancheron 01/01/2019 Oxidative Medicine and Cellular Longevity