Institut de radiobiologie cellulaire et moléculaire - DRF/JACOB

Présentation du laboratoire

L'Institut de recherche en radiobiologie cellulaire et moléculaire (IRCM) est un institut de recherche unique en Europe et qui a une reconnaissance internationale en radiobiologie, radiothérapie, stabilité du génome, cancer et régénération tissulaire. S'appuyant sur la créativité et la prise de risque des chercheurs et sur des plateformes technologiques de pointe, l'IRCM a développé une recherche fondamentale sur des organismes modèles, une recherche sur les pathologies humaines et leurs traitements et une recherche associée au développement industriel.

Les 20 dernières publications

Titre Auteurs Date de publication Source
Multi-species annotation of transcriptome and chromatin structure in domesticated animals S. Vincent-Naulleau 30/12/2019 BMC Biology
Identification of an XRCC1 DNA binding activity essential for retention at sites of DNA damage J. Pablo Radicella, Anna Campalans 01/12/2019 Scientific Reports
Survey of allele specific expression in bovine muscle Emmanuelle Bourneuf 01/12/2019 Scientific reports
EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells Pierre Fouchet, Maëlle Givelet 01/12/2019 Nature Communications
Ontogenic changes in hematopoietic hierarchy determine pediatric specificity and disease phenotype in fusion oncogene– driven myeloid leukemia Francoise Pflumio, Marie Laure Arcangeli 01/12/2019 Cancer Discovery
KLF4 inhibition promotes the expansion of keratinocyte precursors from adult human skin and of embryonic-stem-cell-derived keratinocytes Paul Henri Roméo, Loubna Chadli, Pierre Vaigot, ... 01/12/2019 Nature Biomedical Engineering
Identification of the periplasmic DNA receptor for natural transformation of Helicobacter pylori Prashant P. Damke, J. Pablo Radicella, Xavier Veaute, ... 01/12/2019 Nature Communications
A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease Denise L. Gay 01/12/2019 Nature Communications
Mimicking polyclonal immune response in therapy: from combination of two monoclonal antibodies to oligoclonal antibody-based mixtures Thierry Chardès 01/12/2019 Medecine sciences : M/S
Hypoxia Regulates Lymphoid Development of Human Hematopoietic Progenitors Francoise Pflumio, Irina Naguibneva, Julien Calvo, ... 19/11/2019 Cell Reports
Contribution of single-cell transcriptomics to the characterization of human spermatogonial stem cells: Toward an application in male fertility regenerative medicine? Pierre Fouchet, Clémentine Lapoujade, Anne Sophie Gille 02/11/2019 International Journal of Molecular Sciences
Maternal vitamin C regulates reprogramming of DNA methylation and germline development G. Livera, Marie Justine Guerquin 12/09/2019 Nature
Bystander effectors of chondrosarcoma cells irradiated at different LET impair proliferation of chondrocytes Yannick Saintigny, François Chevalier, Marion Boulanger, ... 01/09/2019 Journal of Cell Communication and Signaling
Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation François Chevalier, Jean Baptiste Austry, Utpal Ghosh, ... 01/08/2019 Journal of Bone Oncology
Interplay between FACT subunit SPT16 and TRIM33 can remodel chromatin at macrophage distal regulatory elements Paul Henri Roméo, Federica Ferri, Vilma Barroca, ... 22/07/2019 Epigenetics and Chromatin
Hematopoietic stem and progenitor cell responses to low radiation doses–implications for leukemia risk Paul Henri Roméo, Nathalie Gault 03/07/2019 International Journal of Radiation Biology
TRIM33 deficiency in monocytes and macrophages impairs resolution of colonic inflammation Marion Dalloz, Paul Henri Roméo, Federica Ferri, ... 01/06/2019 EBioMedicine
A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation Francoise Pflumio, Rima Haddad 01/06/2019 Cancer discovery
The C-terminal domain of HpDprA is a DNA-binding winged helix domain that does not bind double-stranded DNA J. Pablo Radicella, Stéphanie Marsin 01/05/2019 FEBS Journal
Epigenetic silencing affects L-asparaginase sensitivity and predicts outcome in T-ALL Francoise Pflumio 15/04/2019 Clinical Cancer Research