Institut de Chimie des Substances Naturelles

Présentation du laboratoire

Avec un effectif de près de 200 personnes, l'ICSN constitue le pôle chimie du campus CNRS de Gif-sur-Yvette. L'Institut est situé en bordure du futur campus Paris-Saclay, qui regroupera près de 10% de la recherche française, et fait partie intégrante de cette nouvelle Université. L'ICSN développe des activités à l'interface chimie-biologie, avec les substances naturelles comme objet d'étude et source principale d'inspiration.
Organisé en quatre départements, il dispose de compétences pluridisciplinaires en chimie organique exploratoire, en chimie médicinale et substances naturelles, en chimie biologique, et en biologie et chimie structurales et analytiques. Il s'appuie sur un équipement à la pointe et des chercheurs et ingénieurs au savoir-faire unique.
Implanté à l'international, il coordonne de nombreux projets de recherche nationaux et européens. A l'origine de nombreux brevets valorisés et de startups, l'ICSN collabore régulièrement avec des petites et grandes entreprises des domaines pharmaceutiques et agro-alimentaires.

Les 20 dernières publications

Titre Auteurs Date de publication Source
Neuroprotective Effect of CR-777, a Glutathione Derivative of Withaferin A, Obtained through the Bioconversion of Withania somnifera (L.) Dunal Extract by the Fungus Beauveria bassiana Géraldine Le Goff, Guillaume Arcile, Jamal Ouazzani 16/12/2019 Molecules
Enantioselective Gold-Catalyzed Pictet-Spengler Reaction Pascal Retailleau, Xavier Guinchard, Nicolas Glinsky-Olivier 06/12/2019 Organic Letters
Enantioselective Gold(I)-Catalyzed Hydrative Cyclizations of N-Propargyl-ynamides into 3,6-Dihydropyridinones Pascal Retailleau, Arnaud Voituriez, Angela Marinetti, ... 06/12/2019 Organic Letters
Phosphahelicenes with (Thio)Phosphinic Acid and Ester Functions by the Oxidative Photocyclisation Approach Pascal Retailleau, Arnaud Voituriez, Angela Marinetti, ... 05/12/2019 Chemistry - A European Journal
The synthesis and characterization of giant Calixarenes Vincent Guérineau 01/12/2019 Nature Communications
Biosynthetic investigation of γ-lactones in Sextonia rubra wood using in situ TOF-SIMS MS/MS imaging to localize and characterize biosynthetic intermediates Alain Brunelle, David Touboul, Tingting Fu 01/12/2019 Scientific Reports
The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach Veronique Eparvier 01/12/2019 Scientific Reports
Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin Christina Sizun 01/12/2019 Nature Communications
Contalactone, a contaminant formed during chemical synthesis of the strigolactone reference GR24 is also a strigolactone mimic Pascal Retailleau, Frank Pelissier, François Didier Boyer, ... 01/12/2019 Phytochemistry
Defects in t<sup>6</sup>A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome Ewen Lescop 01/12/2019 Nature Communications
Synthesis of novel isoxazolines and isoxazoles of N-substituted pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives through [3+2] cycloaddition Vincent Guérineau, David Touboul 01/12/2019 Arabian Journal of Chemistry
C25 steroids from the marine mussel-derived fungus Penicillium ubiquetum MMS330 Thi Phuong Thuy Hoang 01/12/2019 Phytochemistry Letters
Cytotoxic prenylated flavonoids from the leaves of Macaranga indica Marc Litaudon 01/12/2019 Phytochemistry Letters
Performance evaluation of molecular docking and free energy calculations protocols using the D3R Grand Challenge 4 dataset Bogdan I. Iorga, Edithe Selwa, Eddy Elisée, ... 01/12/2019 Journal of Computer-Aided Molecular Design
Synthesis of Cyclic N-Hydroxylated Ureas and Oxazolidinone Oximes Enabled by Chemoselective Iodine(III)-Mediated Radical or Cationic Cyclizations of Unsaturated N-Alkoxyureas Pascal Retailleau, Kevin Cariou, Laure Peilleron 19/11/2019 Advanced Synthesis and Catalysis
Aerobic Tetrazine-Catalyzed Oxidative Nitroso-Diels-Alder Reaction of N-Arylhydroxylamines with Dienecarbamates: Access to Functionalized 1,6-Dihydro-1,2-oxazines Géraldine Masson, Thibaut Courant, Jérémy Merad, ... 07/11/2019 ChemCatChem
Isolation of phenanthrenes and identification of phorbol ester derivatives as potential anti-CHIKV agents using FBMN and NAP from Sagotia racemosa David Touboul, Marc Litaudon, Fanny Roussi, ... 01/11/2019 Phytochemistry
Pyrrolo-imidazo[1,2- a]pyridine Scaffolds through a Sequential Coupling of N-Tosylhydrazones with Imidazopyridines and Reductive Cadogan Annulation, Synthetic Scope, and Application Pascal Retailleau, Jérôme Bignon, Helene Levaique 01/11/2019 Journal of Organic Chemistry
Scale inhibition effect of Hylocereus undatus solution on calcium carbonate formation Marc Litaudon, Fanny Roussi, Xavier Cachet 15/10/2019 Journal of Crystal Growth
Supercritical fluid chromatography coupled to mass spectrometry for lipidomics Laurent Laboureur, David Touboul, Stephanie Boutet-Mercey, ... 01/10/2019 Journal of Mass Spectrometry