Hypertension artérielle pulmonaire : physiopathologie et innovation thérapeutique

Présentation du laboratoire

L'Inserm UMR-S 999 est un acteur majeur de la recherche translationnelle nationale et internationale sur l'hypertension pulmonaire, à l'origine d'avancées physiopathologiques, médicales et chirurgicales majeures. Elle se subdivise en deux équipes de recherche, physiopathologique et clinique composées de chercheurs, cliniciens et chirurgiens qui travaillent en synergie depuis 2010. Grâce à un registre national de patients (Centre de Référence National de l'Hypertension Pulmonaire Sévère), une biobanque de cellules et tissus et une expertise mondialement reconnue, les deux équipes étudient les mécanismes du remodelage vasculaire pulmonaire et des cardiopathies associées chez l'Homme, le rongeur et le gros animal.

Les 20 dernières publications

Titre Auteurs Date de publication Source
Current use of vasopressors in septic shock Xavier Monnet 01/12/2019 Annals of Intensive Care
Influence of changes in ventricular systolic function and loading conditions on pulse contour analysis-derived femoral dP/dt <inf>max</inf> Jean Louis Teboul, Xavier Monnet, Denis Chemla, ... 01/12/2019 Annals of Intensive Care
Initial management of diabetic ketoacidosis and prognosis according to diabetes type: a French multicentre observational retrospective study Benjamin Sztrymf 01/12/2019 Annals of Intensive Care
Efficacy of immunosuppressants with bridge vasodilator therapy in severe lupus erythematosus-associated pulmonary arterial hypertension Laurent Savale, Marc Humbert 01/12/2019 ESC Heart Failure
Patients with pulmonary arterial hypertension with and without cardiovascular risk factors: Results from the AMBITION trial Gérald Simonneau 01/12/2019 Journal of Heart and Lung Transplantation
Clinical phenotypes and outcomes of precapillary pulmonary hypertension of sickle cell disease Laurent Savale, Marc Humbert, David Montani, ... 01/12/2019 European Respiratory Journal
Pulmonary arterial hypertension registries: Past, present and into the future Marc Humbert, Olivier Sitbon 01/12/2019 European Respiratory Review
How to detect a positive response to a fluid bolus when cardiac output is not measured? Jean Louis Teboul, Xavier Monnet, Nadia Anguel, ... 01/12/2019 Annals of Intensive Care
When one cannot see the forest for the trees: femoral dP/dt <inf>max</inf>, LVEF and pulse pressure in critically ill patients Xavier Monnet, Denis Chemla, S. Vaquer 01/12/2019 Annals of Intensive Care
Pulmonary hypertension due to pulmonary artery obstructions by malignant tumoral cells Laurent Savale 01/11/2019 Respiratory Medicine and Research
BET bromodomain inhibitors and pulmonary arterial hypertension: Take care of the heart Frédéric Perros 01/11/2019 American Journal of Respiratory and Critical Care Medicine
Klippel-Trenaunay syndrome as a rare cause of chronic thromboemboembolic pulmonary hypertension Elie Fadel, Laurent Savale, Marc Humbert, ... 01/11/2019 Respiratory Medicine and Research
Phenotypically Silent Bone Morphogenetic Protein Receptor 2 Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing the Risk for Neointimal Transformation Peter Dorfmüller, Marc Humbert 22/10/2019 Circulation
Inducible cardiac-specific deletion of SIRT1 in male mice reveals progressive cardiac dysfunction and sensitization of the heart to pressure overload Catherine Rucker-Martin 02/10/2019 International Journal of Molecular Sciences
Screening for pulmonary arterial hypertension in systemic sclerosis Laurent Savale, Marc Humbert, David Montani, ... 30/09/2019 European respiratory review : an official journal of the European Respiratory Society
Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension Olaf Mercier, Marc Humbert, David Montani, ... 13/09/2019 Circulation research
Response Denis Chemla 01/09/2019 Chest
Lysyl oxidase-a possible role in systemic sclerosis-associated pulmonary hypertension: a multicentre study Maria Rosa Ghigna, Marc Humbert, Christophe Guignabert 01/09/2019 Rheumatology (Oxford, England)
Seeing the forest for the (arterial) tree: Vascular pruning and the chronic obstructive pulmonary disease pulmonary vascular phenotype Marc Humbert, David Montani 15/08/2019 American Journal of Respiratory and Critical Care Medicine
Response by mendes-ferreira et al to letter regarding article, "bmpr2 mutant rats develop pulmonary and cardiac characteristics of pulmonary arterial hypertension" Frédéric Perros, Grégoire Manaud 13/08/2019 Circulation