Biomarqueurs en cancérologie et onco-hématologie

Présentation du laboratoire

Les activités de recherche du laboratoire BECCOH portent sur les essais cliniques et le développement de biomarqueurs, pour les patients atteints de cancers cutanés, digestifs ou pulmonaires, ou d'histocytoses. Les équipes du laboratoire visent des transversalités fortes en particulier autour du développement et de la validation de biomarqueurs prédictifs et pronostiques permettant une spécification toujours plus poussée de la prise en charge thérapeutique des patients.Le laboratoire BECCOH dispose d'une plateforme de pathologie histologique et moléculaire pour l'étude des néoplasies, et est adossé à un centre de ressources biologiques (CRB) certifié par AFNOR à la norme NF96-900.

Les 20 dernières publications

Titre Auteurs Date de publication Source
Notch signaling molecules as prognostic biomarkers for acute myeloid leukemia P. Takam Kamga 01/12/2019 Cancers
Erdheim-Chester Disease: a Concise Review Jean François Emile 01/12/2019 Current Rheumatology Reports
Resistance mechanisms to osimertinib in EGFR-mutated advanced non-small-cell lung cancer: A multicentric retrospective French study Thierry Chinet, Etienne Giroux Leprieur, Camille Mehlman 01/11/2019 Lung Cancer
Pembrolizumab and concurrent hypo-fractionated radiotherapy for advanced non-resectable cutaneous squamous cell carcinoma P. Saiag, Elisa Funck-Brentano, Christine Longvert, ... 01/11/2019 European Journal of Dermatology
La classification TNM en pratique Etienne Giroux Leprieur 01/10/2019 Revue des Maladies Respiratoires Actualites
Local myofascitis: An unusual adverse reaction to lanreotide autogel injection Marie Laure Raffin-Sanson, Laure Cazabat 01/09/2019 Annales d'Endocrinologie
Plasma biomarkers and immune checkpoint inhibitors in non-small cell lung cancer: New tools for better patient selection? Jean François Emile, Thierry Chinet, Etienne Giroux Leprieur, ... 01/09/2019 Cancers
Mucoadhesive thermosensitive hydrogel for the intra-tumoral delivery of immunomodulatory agents, in vivo evidence of adhesion by means of non-invasive imaging techniques Robert Malafosse, Claude Capron, Katia Lemdani 15/08/2019 International Journal of Pharmaceutics
Role of antibiotic use, plasma citrulline and blood microbiome in advanced non-small cell lung cancer patients treated with nivolumab Jean François Emile, Catherine Julié, Thierry Chinet, ... 10/07/2019 Journal for ImmunoTherapy of Cancer
FOLFOX alone or combined with rilotumumab or panitumumab as first-line treatment for patients with advanced gastroesophageal adenocarcinoma (PRODIGE 17-ACCORD 20-MEGA): a randomised, open-label, three-arm phase II trial Jean François Emile 01/07/2019 European Journal of Cancer
Systemic Histiocytosis (Langerhans Cell Histiocytosis, Erdheim-Chester Disease, Destombes-Rosai-Dorfman Disease): from Oncogenic Mutations to Inflammatory Disorders Jean François Emile 01/07/2019 Current oncology reports
Can we classify ampullary tumours better? Clinical, pathological and molecular features. Results of an AGEO study Jean François Emile 02/04/2019 British Journal of Cancer
Highly sensitive methods are required to detect mutations in histiocytoses Jean Donadieu, Jean François Emile, Zofia Hélias-Rodzewicz, ... 28/02/2019 Haematologica
Inhibition of notch signaling enhances chemosensitivity in B-cell precursor acute lymphoblastic leukemia P. Takam Kamga 01/02/2019 Cancer Research
Sarcoidosis occurring during BRAF/MEK inhibitors is associated with paradoxical ERK activation in Erdheim-Chester patients Jean François Emile, Zofia Hélias-Rodzewicz 01/10/2019 Journal of the European Academy of Dermatology and Venereology
Extracellular vesicles mediate mesenchymal stromal cell-dependent regulation of B cell PI3K-Akt signaling pathway and actin cytoskeleton P. Takam Kamga 01/01/2019 Frontiers in Immunology
Positive plasma cotinine during platinum-based chemotherapy is associated with poor response rate in advanced non-small cell lung cancer patients Jean François Emile, Thierry Chinet, Etienne Giroux Leprieur, ... 01/01/2019 PloS one
Response to trametinib of histiocytosis with an activating PTPN11 mutation Jean François Emile, Zofia Hélias-Rodzewicz 02/01/2020 Leukemia and Lymphoma
Laparoscopic Revision of Bariatric Surgeries in Two Patients with Severe Resistant Hypocalcemia After Endocrine Cervical Surgery Marie Laure Raffin-Sanson, Capucine de Marcellus 01/04/2020 Obesity Surgery
Autoimmunity associated with Erdheim-Chester disease improves with BRAF/MEK inhibitors Jean François Emile 01/01/2019 Haematologica