Strategic Research Initiatives (IRS) are inter-institution research projects accredited by Université Paris Saclay.

These initiatives help laboratories combine forces to address high-level science and technology issues and are developed in conjunction with existing projects. It is through the IRSs, in part, that the joint research strategy set by Université Paris Saclay’s members is to be implemented. They will facilitate development of knowledge and expertise, often in collaboration with industrial and other partners.

Three key fields

  1. Life sciences
  2. Chemistry, environment, materials and energy
  3. Physics, mathematics, and information and communication technology.


  • Funding from Université Paris-Saclay (through IDEX – the excellence initiative program)
  • Funding from Université Paris-Saclay member institutions
  • Industrial commitments
  • Potential support from SATT Paris-Saclay, the technology transfer office

The 23 accredited IRSs


3D - CHROME (3D CHRomosome Organization)

The objective of 3D-CHROME is to consolidate a research and teaching network centered on understanding the biology of chromosomes and their three-dimensional organization, and the impact of this organization during the development of diseases and in evolving species. 3D-CHROME develops technologies for imaging chromosomes in living cells.


BioTherAlliance aims to create a cluster of excellence in biotherapies at Université Paris-Saclay in view of accelerating technology transfer (clinical and industrial). It is a cross-cutting project focused on two areas—gene therapy for neurological diseases and cellular engineering for biotherapies. It brings together life sciences, sociology, mathematics, chemistry and physics teams to invent tools to overcome the technological barriers that are blocking the advancement of biotherapies.


NUTRIPERSO focuses on personalized nutrition and nutritional recommendations to prevent the development of chronic diseases. It studies the prevention of the onset of type 2 diabetes by translating general nutritional recommendations into recommendations tailored to specific individual and population risks, and by measuring the long-term impact on health, the effectiveness and the cost of interventions on individuals according to their social group.

SySABCD (SYStèmes Analytiques pour les Biomarqueurs et la Chimie Durable)

SysABCD is a project involving 24 Paris-Saclay research partners and hospitals. It is designed to create new synergies between analytical science for sustainable chemistry and other fields of application. It aims to develop miniaturized analytical systems and methods for defining disease biomarkers and diagnostic tools.

BME (BioMedical Engineering)

BME is a multidisciplinary project at the interface of physics, chemistry and computer science with biology and medicine that connects 48 research teams from Université Paris-Saclay. Its objective is to accelerate innovation in three areas of life science: chemistry and physics for the exploration of living cells, new microfluidic sensors that are biocompatible and autonomous, and systems and methods in medical imaging.


BRAINSCOPES is an interdisciplinary project in neuroscience and optics that explores the architecture and function of the nervous system in both healthy and diseased states through new imaging techniques. It will be implemented through five collaborative actions to develop both optical and non-optical technologies and methods specific to neuroscience.

B2SRI (Biologie des Systèmes et Synthétique Research Initiative)

B2SRI is a research project involving 22 research teams in quantitative and formal sciences and 12 life sciences teams, thus structuring the research community in systems biology and in one of its applications, synthetic biology. This predictive biology and biological engineering project is designed to model problems in the fields of health, agriculture and biotechnologies.


NanoTheRad aims to improve and personalize the treatment of cancer by radio- and chemotherapy. It involves 36 research teams working at eight Université Paris-Saclay member institutions.

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ACE - ICSEN (Adaptation aux Changements Environnementaux - Institut Climat Société Environnement)

ACE-ICSEN is an integrated research project involving seven teams. It studies the processes of adaptation of living organisms, the erosion of biodiversity and its impacts on organisms’ health in their natural environment and in climatic environments modified by human activity, and explores potentially sustainable economic solutions.


BIOPROBE is a chemistry and physics project focused on synthesizing molecular markers to monitor living matter through analytical cellular imaging, in diagnosis and personalized medicine.

FAPS (Fabrication Additive Paris-Saclay)

FAPS is a project that has 16 Université Paris-Saclay laboratories working on additive manufacturing. It is centered on setting up an experimental platform composed of a SLM Form AddUp 350 machine and a hybrid robot for additive and subtractive manufacturing.

ISC2D (Institut des Sciences Catalytiques pour la Chimie Durable)

ISC2D is an industrial transition project focused on oxygen-rich renewable raw materials such as CO2 and biomass, and bio-based materials and their transformation through efficient, selective and environmentally-respectful processes which use enzymatic tools.

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MOMENTOM (MOlecules and Materials for the ENergy of TOMorrow)

MOMENTOM concerns molecules and materials for the energy of the future. It brings together 26 research laboratories in chemistry, materials physics, the humanities and social sciences, and life sciences. It has both a local dimension, through initiatives on energy and materials, and a European dimension through its contribution to the European strategy of “clean, safe and efficient energy”. The challenges its aims to overcome are crucial to energy transition because they concern energy capture, conversion, catalysis and storage.

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NAN'EAU is an interdisciplinary project that draws on life sciences, chemistry, physics and engineering in the aim of developing a multiple microscopic imaging approach with electron, photon and X-ray imaging. It aims to study the behavioral dynamics of organic, inorganic and living materials in liquid environments such as living cells, as well as nanomaterials for energy production, storage and conversion.


PhyChiM3 brings together 40 research teams working on solar energy, photosynthesis and photoreactive materials, and atmospheric chemistry for the environment and health.


B5GI (Beyond 5G Initiative)

B5GI is an initiative that mobilizes researchers right across Université Paris-Saclay around some of the key issues for future communications: energy consumption, security and upscaling, particularly in the context of the Internet of Things. The research program has been developed in close collaboration with industrial partners from the Paris-Saclay cluster.

CDS2.0 (Center for Data Science)

CDS2.0 is a research and engineering program at Université Paris-Saclay devoted to the emerging field of data science. It follows on from the CDS project, which helped structure UPSaclay’s interdisciplinary data science ecosystem. CDS2.0 draws on skills in data management, statistics, signal processing, automated learning and data visualization for applications in fields ranging from life sciences, physics, and astrophysics to earth and climate sciences.

iCODE (Institute for Control and Decision)

iCODE is an interdisciplinary project that brings UPSaclay researchers together to focus on challenges in various areas of application of control theory, robotics, neuroscience and energy management. It follows on from the iCODE project, which created a reference community made up of research teams in mathematics, engineering, economics and decision science.

IQUPS (Ingénierie Quantique Unversité Paris-Saclay)

IQUPS is destined to become Université Paris-Saclay's center for quantum engineering, based on the many UPSaclay teams which are highly active in this field and enjoy strong international visibility. It will strengthen the facilities used to manufacture quantum devices and combined-theoretical/experimental approaches. This shift towards more applied objectives coincides with the multiplication of physical systems and the expertise of teams that have been at the forefront of the field’s development since the 1980s.

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Psi 2 (Paris-Saclay International Programs for Physical Sciences and their Interfaces)

Psi2 is an initiative that funds and organizes a series of international theme-based programs (two parallel series of programs: one in astrophysics and cosmology and the other in physics and its interfaces), based on long-term visits by high-calibre scientists and academic activities involving them (seminars, courses, etc.).

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SPACEOBS is an incubator designed to integrate Université Paris-Saclay's strengths in the field of space research. It brings together some fifteen laboratories from the Departments of Geosciences and Astrophysics and of Information Science and Technology, involving nine members of UPSaclay. It is a means to initiate synergies for the definition and exploitation of future space missions in collaboration with the French national space agency, and participates in training students in the field of space science.

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SRI (Spintronics Research Initiative)

SRI will be Université Paris-Saclay’s spintronics “hub”. It will facilitate development of future low-power ICT applications in nanoscale physics and spintronics, beyond the limits of current CMOS (Complementary Metal Oxide Semiconductor) technology. Innovative practices in terms of start-ups and the education of young scientists in nanosciences and nanotechnologies through international cooperation will be an essential element of this initiative.

SYDYN (Synergy for Ultrafast Dynamics in Matter)

SYDYN is an interdisciplinary project to develop a research center on ultra-fast dynamics, which studies the evolution of matter in real time and on the smallest time scales currently possible.