Le centre ImVA, est une Unité Mixte de Recherche entre le CEA de Fontenay-aux-Roses (UMR E1 CEA-PSUD), l’Université Paris-Sud et l’INSERM (Hôpital du Kremlin Bicêtre/Unité1012).
At the Fontenay-aux-Roses campus, we will have access to the “Infectious Diseases Models for Innovative Therapies (IDMIT) infrastructure” :
- 1500 m2 of laboratories and offices with flow cytometry, mass cytometry (Equipex 2010 investment), and cell sorting suites (in BSL2 and BSL3 containment conditions);
- NHP facilities with BSL2 and BSL3 containment and in vivo imaging equipment (near-infrared fluorescence, confocal endomicroscopy, bi-photon microscopy, PET-CT).
The IDMIT infrastructure (see below) will be hosted in a new building housing center staff (2016), with a total area of 8800 m2, and to fund sustained improvements in technology, including a PET-CT machine in BSL3 containment conditions. Also, the proximity of the center to the MIRCen infrastructure will facilitate access to 7T MRI for NHPs in BSL2 and BSL3 containment conditions. MIRCen has considerable expertise in preclinical models for neurological diseases, including experimental autoimmune encephalitis (EAE) and multiple sclerosis (MS) in macaques.
At Bicêtre Hospital, the laboratory occupies 450 m2 and has excellent facilities for cell sorting in BSL2 containment, flow cytometry, in vitro imaging and mouse facilities. A new wing of the medical school will make it possible to increase the area available for research activities and to develop new animal facilities. Finally, clinical interfaces are facilitated through daily clinical duties in five different clinical units and strong involvement in translational medicine and therapeutic trials, together with the excellent core facilities available for translational research (clinical investigation center, biological banks, strong interfaces with the Immunology Department).