[{"command":"insert","method":null,"selector":".course-modal-ajax-placeholder-961068","data":"\u003Cdiv class=\u0022container content-rte\u0022\u003E\n  \u003Cdiv class=\u0022row\u0022\u003E\n    \u003Cdiv class=\u0022box col-md-6 bg-primary text-white\u0022\u003E\n      \u003Ch2 class=\u0022h1 text-left\u0022\u003E  Chimie pharmaceutique : \u00ab Approches Innovantes en Conception de M\u00e9dicaments \u00bb\n\u003C\/h2\u003E\n                  \u003Cdiv class=\u0022field-spacing\u0022\u003E\n        \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EECTS :\n          6\n        \u003C\/div\u003E\n      \u003C\/div\u003E\n                  \u003Cdiv class=\u0022field-spacing\u0022\u003E\n        \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ESemester:\n          Semestre 1\n        \u003C\/div\u003E\n      \u003C\/div\u003E\n            \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ED\u00e9tail du volume horaire\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                          \u003Cspan class=\u0022field__label h4 mt-5 \u0022\u003ELecture:\u003C\/span\u003E\n                                      \u003Cspan\u003E24\u003C\/span\u003E\n                      \u003C\/div\u003E\n                                \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                          \u003Cspan class=\u0022field__label h4 mt-5 \u0022\u003EPractical study :\u003C\/span\u003E\n                                      \u003Cspan\u003E15\u003C\/span\u003E\n                      \u003C\/div\u003E\n                                \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                          \u003Cspan class=\u0022field__label h4 mt-5 \u0022\u003EDirected study:\u003C\/span\u003E\n                                      \u003Cspan\u003E6\u003C\/span\u003E\n                      \u003C\/div\u003E\n                                                            \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ELangue d\u0026#039;enseignement\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003EFran\u00e7ais\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EEnseignement \u00e0 distance\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003Enon\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n      \u003C\/div\u003E\n    \u003Cdiv class=\u0022box col-md-6\u0022\u003E\n            \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EPr\u00e9requis\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cul\u003E\n\u003Cli\u003EMa\u00eetriser les principales r\u00e9actions en chimie organique ;\u003C\/li\u003E\n\u003Cli\u003ENotions de base sur les propri\u00e9t\u00e9s physicochimiques des mol\u00e9cules organiques et sur leur analyse ;\u003C\/li\u003E\n\u003Cli\u003ENotions de bases de chimie m\u00e9dicinale (principales cibles des m\u00e9dicaments, concept de relation structure-activit\u00e9, pharmacomodulation pour la conception de nouvelles mol\u00e9cules bioactives).\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EProgramme \/ plan \/ contenus\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cul\u003E\n\u003Cli\u003E\n\u003Cp\u003EI \u2013 Outils biophysiques pour l\u2019\u00e9tude d\u2019interactions biologiques et la d\u00e9couverte de m\u00e9dicaments ;\u0026nbsp;\u003C\/p\u003E\n\u003C\/li\u003E\n\u003Cli\u003E\n\u003Cp\u003EII- Conjugu\u00e9s et d\u00e9gradation Cibl\u00e9e : nouvelles strat\u00e9gies th\u00e9rapeutiques\u003C\/p\u003E\n\u003Cp\u003EII.a. Les conjugu\u00e9s anticorps-m\u00e9dicament (ADC) en chimie m\u00e9dicinale\u0026nbsp;\u003C\/p\u003E\n\u003Cp\u003EII.b. PROTACs : vers une nouvelle \u00e8re de la d\u00e9gradation cibl\u00e9e des prot\u00e9ines\u0026nbsp;\u003C\/p\u003E\n\u003C\/li\u003E\n\u003Cli\u003E\n\u003Cp\u003EIII- Modulation allost\u00e9rique et inhibition covalente en chimie m\u00e9dicinale ;\u0026nbsp;\u003C\/p\u003E\n\u003Cp\u003EIII.a. Ciblage allost\u00e9rique et modulation non orthost\u00e9rique des r\u00e9cepteurs ;\u003C\/p\u003E\n\u003Cp\u003EIII.b. D\u00e9veloppement de m\u00e9dicaments covalents : m\u00e9canismes, sp\u00e9cificit\u00e9 et exemples r\u00e9cents \u0026nbsp;;\u003C\/p\u003E\n\u003C\/li\u003E\n\u003Cli\u003E\n\u003Cp\u003EIV. Approches \u00e9mergentes pour la m\u00e9decine de pr\u00e9cision : Approches \u00e9pig\u00e9n\u00e9tiques et polypharmacologiques en conception de m\u00e9dicaments ;\u003C\/p\u003E\n\u003C\/li\u003E\n\u003Cli\u003E\n\u003Cp\u003EV- Peptidomim\u00e9tiques: nouveaux m\u00e9dicaments, ciblage, passage membranaire, synth\u00e8se ;\u0026nbsp;\u003C\/p\u003E\n\u003C\/li\u003E\n\u003Cli\u003E\n\u003Cp\u003EVI- Mod\u00e9lisation mol\u00e9culaire et Intelligence artificielle pour la conception de mol\u00e9cules actives.\u003C\/p\u003E\n\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EObjectifs d\u0026#039;apprentissage\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cul\u003E\n\u003Cli\u003EMaitriser les strat\u00e9gies de conception et d\u0027optimisation de candidat-m\u00e9dicament\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EOrganisation g\u00e9n\u00e9rale et modalit\u00e9s p\u00e9dagogiques\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cp\u003EDes cours magistraux appuy\u00e9s par des TD sur articles scientifiques seront dispens\u00e9s. Des TP sur projets seront effectu\u00e9s en mod\u00e9lisation mol\u00e9culaire.\u003C\/p\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n                        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EBibliographie\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003E\u003Cp\u003ERevues sur les interactions prot\u00e9ine-prot\u00e9ine : a) Toward Small-Molecule Inhibition of Protein\u2013Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions, Curr Top Med Chem. 2018, 18, 674. b) Inhibitors of Protein-Protein Interactions (PPIs): An Analysis of Scaffold Choices and Buried Surface Area, Curr Opin Chem Biol. 2018, 44, 75.\u003C\/p\u003E\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n        \u003Cdiv class=\u0022field-spacing\u0022\u003E\n      \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ENature de l\u0026#039;\u00e9valuation\u003C\/div\u003E\n                        \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n                                      \u003Cspan\u003EEvaluation Continue non Int\u00e9grale\u003C\/span\u003E\n                      \u003C\/div\u003E\n                  \u003C\/div\u003E\n      \u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n","settings":null}]