[{"command":"insert","method":null,"selector":".course-modal-ajax-placeholder-958547","data":"\u003Cdiv class=\u0022container content-rte\u0022\u003E\n \u003Cdiv class=\u0022row\u0022\u003E\n \u003Cdiv class=\u0022box col-md-6 bg-primary text-white\u0022\u003E\n \u003Ch2 class=\u0022h1 text-left\u0022\u003E Prokaryotic genomics\n\u003C\/h2\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EECTS :\n 3\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ESemester:\n Semestre 2\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ED\u00e9tail du volume horaire\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan class=\u0022field__label h4 mt-5 \u0022\u003ELecture:\u003C\/span\u003E\n \u003Cspan\u003E9\u003C\/span\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan class=\u0022field__label h4 mt-5 \u0022\u003EDirected study:\u003C\/span\u003E\n \u003Cspan\u003E13.5\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ELangue d\u0026#039;enseignement\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003EAnglais\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EEnseignement \u00e0 distance\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003Enon\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022box col-md-6\u0022\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EPr\u00e9requis\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003E\u003Cp\u003E\u25cf\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Basic knowledge of molecular biology, microbial genetics, and genomics\u003Cbr\u003E\n\u25cf\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Familiarity with sequence formats (FASTA, GFF, GenBank)\u003Cbr\u003E\n\u25cf\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Awareness of databases such as NCBI, UniProt, and KEGG\u003C\/p\u003E\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EProgramme \/ plan \/ contenus\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003E\u003Cp\u003E1. Introduction to Prokaryotic Genomes\u003Cbr\u003E\n2. Genome Annotation\u0026nbsp;\u003Cbr\u003E\n3. Comparative Genomics\u0026nbsp;\u003Cbr\u003E\nConcepts: orthology, synteny, gene conservation, rearrangements\u003Cbr\u003E\n4. Pangenomics and Pangenome Graphs\u003Cbr\u003E\n5. Metabolic Reconstruction and Comparative Metabolism analysis\u003Cbr\u003E\n6. Integrative Project: Comparative Genomics, Pangenome, and\/or Metabolic Reconstruction\u003C\/p\u003E\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EObjectifs d\u0026#039;apprentissage\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003E\u003Cp\u003EBy the end of this course, students will be able to:\u003Cbr\u003E\n1.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Describe the structure, organization, and variability of prokaryotic genomes\u003Cbr\u003E\n2.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Perform genome annotation using reference pipelines and databases.\u003Cbr\u003E\n3.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Compare genomes across species to identify orthologous and unique genes.\u003Cbr\u003E\n4.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Reconstruct and analyze metabolic pathways from annotated genomes.\u003Cbr\u003E\n5.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Build, interpret, and visualize pangenomes using comparative genomics tools.\u003Cbr\u003E\n6.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Understand how genome diversity relates to functional and ecological adaptation\u003C\/p\u003E\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EOrganisation g\u00e9n\u00e9rale et modalit\u00e9s p\u00e9dagogiques\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003E\u003Cp\u003ETeaching methods:\u003C\/p\u003E\n\u003Cul\u003E\n\u003Cli\u003ELectures: conceptual and methodological foundations\u003C\/li\u003E\n\u003Cli\u003EPractical sessions: data annotation, comparative genomics, and metabolic analysis\u003C\/li\u003E\n\u003Cli\u003ETutorials: case discussions and interpretation of results\u003C\/li\u003E\n\u003Cli\u003EProject-based learning: small group work on a microbial dataset\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EComp\u00e9tences\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003E\u003Cp\u003EC1.1. Formuler des probl\u00e9matiques et des hypoth\u00e8ses de travail permettant la conception et la r\u00e9alisation d\u2019un projet dans son domaine d\u2019expertise et \/ou \u00e0 l\u2019interface de plusieurs domaines en biologie.\u003C\/p\u003E\n\u003Cp\u003EC1.4. Produire et valider des donn\u00e9es scientifiques.\u003C\/p\u003E\n\u003Cp\u003EC2.1. Actualiser ses connaissances th\u00e9oriques et technologiques par une veille dans son domaine en relation avec l\u2019\u00e9tat de la recherche.\u003C\/p\u003E\n\u003Cp\u003EC2.3. Se former \u00e0 de nouveaux outils technologiques.\u003C\/p\u003E\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003EBibliographie\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003E\u003Cp\u003E\u25cf\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Tettelin H, et al. . Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial \u0022pan-genome\u0022. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13950-5. doi: 10.1073\/pnas.0506758102. Epub 2005 Sep 19. Erratum in: Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16530. PMID: 16172379; PMCID: PMC1216834.\u003Cbr\u003E\n\u25cf\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Gautreau G, et al. . PPanGGOLiN: Depicting microbial diversity via a partitioned pangenome graph. PLoS Comput Biol. 2020 Mar 19;16(3):e1007732. doi: 10.1371\/journal.pcbi.1007732. Erratum in: PLoS Comput Biol. 2021 Dec 10;17(12):e1009687. doi: 10.1371\/journal.pcbi.1009687. PMID: 32191703; PMCID: PMC7108747.\u003C\/p\u003E\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003Cdiv class=\u0022field-spacing\u0022\u003E\n \u003Cdiv class=\u0022field__label h3 dash\u0022\u003ENature de l\u0026#039;\u00e9valuation\u003C\/div\u003E\n \u003Cdiv class=\u0022mt-5 text-justify\u0022\u003E\n \u003Cspan\u003EEvaluation Continue non Int\u00e9grale\u003C\/span\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n\u003C\/div\u003E\n","settings":null}]