GO Paris-Saclay and Evry Paris-Saclay, two teams of students from Université Paris-Saclay, each won a gold medal at the International Genetically Engineered Machine competition (iGEM 2018) held in Boston in late October. The Evry Paris-Saclay team was also nominated in the "Best New Composite Part" category for BBa_K2675042, a cassette of expression and secretion of hexapeptide SAIRGA in E. coli.
The Evry Paris-Saclay team, composed of students from Université Paris-Saclay (14 students from Université d’Evry, 1 student from Université Paris-Sud) and one student from Université Paris 1 Panthéon-Sorbonne, has developed a synthetic biology project. Entitled "PepTalk: Repurposing Bacteriophage Peptide Signals For Expanded Bacterial Communication Vocabulary," it provides the foundations for the development of an orthogonal intercellular communication system in E. coli (see project at http://2018.igem.org/Team:Evry_Paris-Saclay).
The project was developed with the financial support of several partners including Université d’Evry, Genopole and Université Paris-Saclay & Investissements d'Avenir through the supervision of iSSB laboratories within UMR 8030 Génomique Métabolique (CEA-CNRS-UEVE, Evry), Micalis (INRA-APT, Jouy-en-Josas) and through access to the Genopole abSYNTH synthetic biology platform.
The Paris-Saclay GO team, composed of students from Université Paris-Saclay (Université Paris-Sud, AgroParisTech and ENSTA), has developed a synthetic biology project entitled "MethotrExit: The HeteroGenious Cleaning Factory." The project is based on the development of strains capable of effectively degrading a hospital wastewater pollutant (methotrexate) and on the design of a synthetic expression system to generate a division of labor in populations of bacteria (see project at http://2018.igem.org/Team:GO_Paris-Saclay).
This project was developed thanks to financial support from several partners, including I2BC (UMR 9198), Université Paris-Saclay & Investissements d'Avenir and Université Paris-Sud (including the project FSDIE, Magister degree in Biology and Second year of master's in fundamental microbiology in the Biology-Health curriculum) and through the supervision of the I2BC laboratories (UMR 9198).