Published on 5 June 2015
Europe

Find vaccines against viral diseases in cattle and pigs

SAPHIR for Strengthening Animal Production and Health through Immune Response was selected by the European Commission under the research program Horizon 2020 and the security sustainable food call and priority community challenges. It aims to develop vaccine strategies against endemic pathogens causing major economic losses in cattle farms, pig and poultry. It involves 14 research institutes, SMEs 5 and a pharmaceutical company, from 11 European countries and China. The total amount of the project is 10.7 million, including 9 million by the Commission and 1.7 million by the Swiss government. Its duration is 4 years.

SAPHIR, project coordinated by INRA, is original to involve, through the various private and public partners, European and Chinese scientists for excellence in various disciplines for an integrated approach (pathologists, geneticists, microbiologists, sociologists, economists, mathematicians ...).

The objectives of SAPHIR and the expected innovations
Scientifically: decipher the mechanisms of the immune response and action of the pathogen, understanding the impact of animal profile in the vaccine response (genetics, age ...), optimize the formulation of vaccines and adjuvants to induce immunity fast, wide and long, inducing mucosal immunity.
 
Technologically: developing vaccine production from new technologies, enabling safe and epidemiological control of diseases, developing effective and easy to use methods, identify immuno-competence markers for selection of hardier animals.
 
At socio-economic level understand the socio-economic factors that influence the use and acceptability of vaccines by professionals and communicate with stakeholders through integrated strategies for health on farms.
 
Scientists gathered in this project are interested in representative conditions of each of the sectors for which vaccination is nonexistent or ineffective on the ground:
for cattle, bovine respiratory syncytial virus and Mycoplasma bovis,
for pigs, the virus of porcine reproductive and respiratory syndrome and Mycoplasma hyopneumoniae, for poultry, Eimeria sp. and Clostridium perfringens.