Published on 19 May 2015
Research
Fibroblaste

soon patented on a protease responsible for this disease.

The Institut Pasteur and CNRS researchers, in collaboration with scientists from the CEA and the Institut Gustave Roussy, were able to restore normal activity in cells from patients with early aging syndrome, Cockayne syndrome. They found the involvement in this pathology of the protease HTRA3 enzyme. Overexpressed in patients, it causes a malfunction of the mitochondria, which play a key role in the onset of aging symptoms in children. This work, published in the PNAS Plus journal, describe one of the mechanisms responsible for the premature aging hitherto unknown and will enlighten the aging process in general.

Read in french the communiqué de presse on CNRS website.

Publication source :

Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome, PNAS, May 18, 2015
Laurent Chatre, Denis Biard, Alain Sarasin, and Miria Ricchetti.