Signalisation et physiopathologie cardiovasculaire

Laboratory presentation

The SPC revolves around three teams developing complementary themes on animal and cell models to study the mechanisms involved in cardiac function through membrane receptors, ion channels, cyclic nucleotides, energy metabolism, calcium, and intracellular compartments. The unit aims to elucidate new pathophysiological mechanisms and identify new therapeutic targets in the treatment of heart failure and arrhythmias. It is in charge of innovative projects within the LabEx LERMIT in partnership with other laboratories of the IPSIT.

The 20 latest publications

Title Authors Publication date Source
The ESC Working Group Cardiac Cellular Electrophysiology Ana Maria Gómez 12/07/21 European heart journal
Macrophage responses associated with COVID-19: A pharmacological perspective Nada J. Habeichi 11/15/20 European Journal of Pharmacology
Targeting Orai1-Mediated Store-Operated Ca<sup>2+</sup> Entry in Heart Failure Jessica Sabourin, Ana Maria Gómez, Jean Pierre Benitah, ... 10/08/20 Frontiers in Cell and Developmental Biology
Fibroblast growth factor 23 decreases PDE4 expression in heart increasing the risk of cardiac arrhythmia; Klotho opposes these effects Delphine Mika, Rodolphe Fischmeister 09/01/20 Basic Research in Cardiology
AIF meets the CHCHD4/Mia40-dependent mitochondrial import pathway Nazanine Modjtahedi, Camille Reinhardt, Kenza Nedara, ... 06/01/20 Biochimica et Biophysica Acta - Molecular Basis of Disease
Sex-based differences in myocardial infarction-induced kidney damage following cigarette smoking exposure: more renal protection in premenopausal female mice Nada J. Habeichi 06/01/20 Bioscience reports
β-adrenergic regulation of the L-type Ca<sup>2+</sup> current: The missing link eventually discovered Jérôme Leroy, Rodolphe Fischmeister 06/01/20 Medecine/Sciences
Excitation-contraction coupling and relaxation alteration in right ventricular remodelling caused by pulmonary arterial hypertension Jessica Sabourin 01/01/20 Archives of Cardiovascular Diseases
Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca<sup>2+</sup> Handling After Pressure Overload Jessica Sabourin, Florence Lefebvre, Fiona Bartoli, ... 01/01/20 Circulation
Implication of the deacetylase sirtuin-1 on synovial angiogenesis and persistence of experimental arthritis Christophe Lemaire, Julie Pires Da Silva 07/01/20 Annals of the Rheumatic Diseases
Investigating cardiac β-adrenergic nuclear signaling with FRET-based biosensors Grégoire Vandecasteele, Ibrahim Bedioune 01/01/20 Annales d'Endocrinologie
Response by Benitah et al to Letter Regarding Article, "orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca<sup>2+</sup> Handling after Pressure Overload" Jessica Sabourin, Jean Pierre Benitah 06/02/20 Circulation
BET bromodomain inhibitors and pulmonary arterial hypertension: Take care of the heart Jérôme Piquereau 11/01/19 American Journal of Respiratory and Critical Care Medicine
Disturbed fatty acid oxidation, endoplasmic reticulum stress, and apoptosis in left ventricle of patients with type 2 diabetes Christophe Lemaire, Mélanie Gressette 10/01/19 Diabetes
Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction A. Guellich, Delphine Mika, Grégoire Vandecasteele, ... 10/01/19 Cardiovascular Research
Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension Valérie Domergue 09/13/19 Circulation research
The oyster Crassostrea gigas, a new model against cancer C. Brenner 01/01/19 Medecine sciences : M/S
Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension Jessica Sabourin, Ana Maria Gómez, Boris Manoury 02/12/19 Circulation
Endoplasmic reticulum stress induces cardiac dysfunction through architectural modifications and alteration of mitochondrial function in cardiomyocytes Christophe Lemaire, Renée Ventura-Clapier, Anne Garnier, ... 02/01/19 Cardiovascular research
Is Epac1 a good therapeutic strategy against cardiac remodelling? Laetitia Pereira 01/01/19 Cardiovascular research

Nombre de publications du laboratoire par domaine scientifique

Chaque publication du laboratoire peut être rangée dans une ou plusieurs disciplines scientifiques : la figure ci-dessus présente le nombre de publications du laboratoire pour chaque discipline de la classification ASJC (Elsevier)