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Institut de Chimie des Substances Naturelles

Laboratory presentation

With a staff of nearly 200 people, ICSN is the chemistry center of the CNRS campus of Gif-sur-Yvette. The Institute is located on the edge of the future Paris-Saclay campus, which will bring together nearly 10% of French research, and is an integral part of this new University. The ICSN develops activities at the chemistry-biology interface, with natural substances as object of study and main source of inspiration.
Organized in four departments, it has multidisciplinary expertise in organic exploratory chemistry, medicinal chemistry and natural substances, biological chemistry, and structural and analytical biology and chemistry. It relies on state-of-the-art equipment and researchers and engineers with unique know-how.
Internationally, it coordinates numerous national and European research projects. At the origin of many valued patents and startups, the ICSN regularly collaborates with small and large companies in the pharmaceutical and agro-food fields.

The 20 latest publications

Title Authors Publication date Source
Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins François Bontems 07/05/22 EMBO Reports
Fluorescent Cu<sup>2+</sup> sensor based on phenanthroline-BODIPY conjugate: A mechanistic study Pascal Retailleau 07/01/22 Dyes and Pigments
A one-pot synthesis and X-Ray structural characterization of new highly substituted-allyl carbamates Benoit Crousse 06/15/22 Journal of Molecular Structure
Expansion of the Strigolactone Profluorescent Probes Repertory: The Right Probe for the Right Application Guillaume Clavé, Arnaud Chevalier, Suzanne Daignan Fornier, François Didier Boyer 06/02/22 Frontiers in Plant Science
Exploring the Biosynthetic Potential of TsrM, a B<inf>12</inf>-dependent Radical SAM Methyltransferase Catalyzing Non-radical Reactions Nazarii Sabat, Xavier Guinchard 06/01/22 Chemistry - A European Journal
Bacterial Nucleotidyl Cyclases Activated by Calmodulin or Actin in Host Cells: Enzyme Specificities and Cytotoxicity Mechanisms Identified to Date Pascal Retailleau 06/01/22 International Journal of Molecular Sciences
2,3,5-Tri-O-benzyl-D-xylofuranose Pascal Retailleau 06/01/22 MolBank
The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis Bogdan I. Iorga 05/31/22 Proceedings of the National Academy of Sciences of the United States of America
Chiral Phosphoric Acid-Catalyzed Enantioselective Formal [4+2] Cycloaddition Between Dienecarbamates and 2-Benzothioazolimines Wei Yang Ma, Emeric Montinho-Inacio, Bogdan I. Iorga, Pascal Retailleau, Luc Neuville, Géraldine Masson 05/17/22 Advanced Synthesis and Catalysis
Base-Mediated Generation of Ketenimines from Ynamides: Addition of Hydrazones to Give Acetimidohydrazides** Capucine Mahe, Agathe C.A. D'Hollander 05/13/22 European Journal of Organic Chemistry
Treating leishmaniasis in Amazonia, part 2: Multi-target evaluation of widely used plants to understand medicinal practices Véronique Eparvier 05/10/22 Journal of Ethnopharmacology
A structural homologue of the plant receptor D14 mediates responses to strigolactones in the fungal phytopathogen Cryphonectria parasitica François Didier Boyer 05/01/22 New Phytologist
Anti Regiospecificity in the Photosensitized Cycloaddition of 4-Tetrazolouracil Nucleoside<sup>†</sup> Frédéric Peyrane 05/01/22 Photochemistry and Photobiology
Dynamic imaging of cell wall polysaccharides by metabolic click-mediated labeling of pectins in living elongating cells Aurélie Baron, Laura Fourmois, Boris Vauzeilles 05/01/22 Plant Journal
Synthesis of Dihydro-5H-Benzo[c]-Fluorenes, Dihydroindeno[c]-Chromenes and Thiochromenes via Intramolecular Cyclization and their Effect on Human Leukemia Cells Jun Yan, Christine Tran, Olivier Provot, Abdallah Hamze 04/26/22 Advanced Synthesis and Catalysis
ICBS 2021: Looking Toward the Next Decade of Chemical Biology Boris Vauzeilles 04/15/22 ACS Chemical Biology
Dereplication of Acetogenins from Annona muricata by Combining Tandem Mass Spectrometry after Lithium and Copper Postcolumn Cationization and Molecular Networks Pierre Champy 04/06/22 Journal of the American Society for Mass Spectrometry
Enantioselective Au(I)-Catalyzed Multicomponent Annulations via Tethered Counterion-Directed Catalysis Zhenhao Zhang, Nazarii Sabat, Angela Marinetti, Xavier Guinchard 04/01/22 ACS Catalysis
Optimization of the rapid carbapenem inactivation method for use with AmpC hyperproducers-authors' response Mǎdǎlina Maria Muntean, Andrei Alexandru Muntean, Elodie Creton, Garance Cotellon, Saoussen Oueslati, Delphine Girlich, Rémy A. Bonnin, Thierry Naas 04/01/22 Journal of Antimicrobial Chemotherapy
Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller François Bontems 03/07/22 Journal of Experimental Medicine

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)