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Ingénierie et Plateformes au Service de l'Innovation Thérapeutique

Laboratory presentation

L’Institut Paris Saclay d’Innovation Thérapeutique (IPSIT) is a mixed unit of service (UMS) composed of 11 technological platforms. It plays a leading role in the development of the scientific projects of the associated units of Châtenay-Malabry, Clamart and Plessis Robinson sites whose common objectives are to identify new therapeutic targets. IPSIT is also at the service of private and public research laboratories from the Île-de-France Sud region.

The 20 latest publications

Title Authors Publication date Source
Rapid assessment of fatty acyls chains of phospholipids and plasmalogens by atmospheric pressure chemical ionization in positive mode and high-resolution mass spectrometry using in-source generated monoacylglycerol like fragments intensities Audrey Solgadi, Bastien Prost 06/21/22 Journal of Chromatography A
Hippocampal Excitatory Synaptic Transmission and Plasticity Are Differentially Altered during Postnatal Development by Loss of the X-Linked Intellectual Disability Protein Oligophrenin-1 F. Dumont 05/01/22 Cells
Transcriptional profiling of β-2M<sup>−</sup>SPα-6<sup>+</sup>THY1<sup>+</sup> spermatogonial stem cells in human spermatogenesis Maelle Givelet, Virginie Firlej, Bruno Lassalle, Anne Sophie Gille, Clementine Lapoujade, Amandine Jarysta, Françoise Pflumio, Isabelle Allemand, Lydia Riou, Pierre Fouchet 04/12/22 Stem Cell Reports
Before in vivo studies: In vitro screening of sphingomyelin nanosystems using a relevant 3D multicellular pancreatic tumor spheroid model Nadège Bidan, Aure Vanhecke, S. Mura 04/05/22 International Journal of Pharmaceutics
Modulation of the Bile Acid Enterohepatic Cycle by Intestinal Microbiota Alleviates Alcohol Liver Disease Dragos Ciocan, Madeleine Spatz, Nicolas Trainel, Kévin Hardonnière, Cindy Hugot, Gabriel Perlemuter, Anne Marie Cassard 03/01/22 Cells
The unforeseen intracellular lifestyle of Enterococcus faecalis in hepatocytes Nicolas Trainel, Anne Marie Cassard 01/01/22 Gut Microbes
Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only Audrey Solgadi 12/01/21 Biology of Sex Differences
The linoleic acid content of the stratum corneum of ichthyotic golden retriever dogs is reduced as compared to healthy dogs and a significant part is oxidized in both free and esterified forms Audrey Solgadi 12/01/21 Metabolites
Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues Bastien Prost 11/05/21 European Journal of Medicinal Chemistry
Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload Valérie Domergue 11/01/21 Cardiovascular Research
Multi-tissue characterization of GILZ expression in dendritic cell subsets at steady state and in inflammatory contexts Molène Docq, Mathias Vétillard, Carmen Gallego, Agnieszka Jaracz-Ros, Françoise Mercier-Nomé, Françoise Bachelerie, Géraldine Schlecht-Louf 11/01/21 Cells
Gut microbiota reshaped by pectin treatment improves liver steatosis in obese mice Camille Houron, Dragos Ciocan, Nicolas Trainel, Cindy Hugot, Madeleine Spatz, Gabriel Perlemuter, Anne Marie Cassard 11/01/21 Nutrients
Rapid assessment of triacylglycerol fatty acyls composition by LC-APPI<sup>+</sup>-HRMS using monoacylglycerol like fragments intensities Audrey Solgadi 09/15/21 Analytica Chimica Acta
Tuning morphology of Pickering emulsions stabilised by biodegradable PLGA nanoparticles: How PLGA characteristics influence emulsion properties Valérie Nicolas 08/01/21 Journal of Colloid and Interface Science
Saccharomyces cerevisiae DNA repair pathways involved in repair of lesions induced by mixed ternary mononuclear Cu(II) complexes based on valproic acid with 1,10-phenanthroline or 2,2’- bipyridine ligands Françoise Dumas 08/01/21 Mutation Research - Genetic Toxicology and Environmental Mutagenesis
Phospholipids: Identification and implication in muscle pathophysiology Audrey Solgadi, Bastien Prost 08/01/21 International Journal of Molecular Sciences
Transtympanic injection of a liposomal gel loaded with N-acetyl-L-cysteine: A relevant strategy to prevent damage induced by cochlear implantation in guinea pigs? Audrey Solgadi 07/15/21 International Journal of Pharmaceutics
Detection of LongR<sup>3</sup>-IGF-I, Des(1-3)-IGF-I, and R<sup>3</sup>-IGF-I using immunopurification and high resolution mass spectrometry for antidoping purposes Valérie Domergue 07/01/21 Drug Testing and Analysis
Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury Laura Wrzosek, Dragos Ciocan, Cindy Hugot, Madeleine Spatz, Margot Dupeux, Camille Houron, Vanessa Liévin-Le Moal, Virginie Puchois, Gladys Ferrere, Nicolas Trainel, Cosmin Sebastian Voican, Gabriel Perlemuter, Anne Marie Cassard 07/01/21 Gut
Cochleate formulations of Amphotericin b designed for oral administration using a naturally occurring phospholipid Valérie Nicolas, Bastien Prost 06/15/21 International Journal of Pharmaceutics

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)