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Immunologie intégrative des tumeurs et immunothérapie des cancers

Laboratory presentation

The laboratory Tumor Integrative Immunology is studying tumor antigens, T-cell reactivity, the impact of the tumor microenvironment on tumor resistance (role on plasticity in particular) and more generally genetics and biology of breast cancer, lung, kidneys and cancers related to melanomas. This work are undertaken thanks to partnerships with industrial companies, which has allowed 2 patents filing as well as the creation of 2 startups and the development of new innovative immunotherapy approaches.

The 20 latest publications

Title Authors Publication date Source
The Promise of Targeting Hypoxia to Improve Cancer Immunotherapy: Mirage or Reality? Salem Chouaib 06/20/22 Frontiers in Immunology
BCG therapy downregulates HLA-I on malignant cells to subvert antitumor immune responses in bladder cancer Julien Adam 06/15/22 Journal of Clinical Investigation
Genomic Analysis of Waterpipe Smoke-Induced Lung Tumor Autophagy and Plasticity Salem Chouaib 06/01/22 International Journal of Molecular Sciences
Vaccine Therapy in Non-Small Cell Lung Cancer Stéphanie Corgnac 05/01/22 Vaccines
Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition Jean Paul Thiery, Salem Chouaib, Stéphane Terry 04/27/22 Frontiers in Immunology
Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models Jean Paul Thiery 04/22/22 Frontiers in Oncology
Cancer stem-like cells evade CD8<sup>+</sup>CD103<sup>+</sup> tumor-resident memory T (T<inf>RM</inf>) lymphocytes by initiating an epithelial-to-mesenchymal transition program in a human lung tumor model Aziza Caidi, Marc Deloger 04/13/22 Journal for ImmunoTherapy of Cancer
Outcome of Progressive Multifocal Leukoencephalopathy Treated by Interleukin-7 Jacques Gasnault 04/01/22 Annals of Neurology
Modulating tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors: A TAM-pting approach Salem Chouaib 03/01/22 Pharmacology and Therapeutics
The Effect of Hypoxia and Hypoxia-Associated Pathways in the Regulation of Antitumor Response: Friends or Foes? Jérôme Thiery, Stéphane Terry, Salem Chouaib 02/08/22 Frontiers in Immunology
The proliferation of belatacept-resistant T cells requires early IFNα pathway activation Florence Herr, Karen Bargiel, Amelia Vernochet, Fan Ye, Manon Dekeyser, Antoine Durrbach 02/01/22 American Journal of Transplantation
Plasmacytoid urothelial carcinoma (UC) are luminal tumors with similar CD8+ Tcell density and PD-L1 protein expression on immune cells as compared to conventional UC Julien Adam 01/01/22 Urologic Oncology: Seminars and Original Investigations
Association of AXL and PD-L1 Expression with Clinical Outcomes in Patients with Advanced Renal Cell Carcinoma Treated with PD-1 Blockade Nathalie Chaput 12/15/21 Clinical Cancer Research
Integrin-α<inf>V</inf>-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade Ines Malenica, Julien Adam, Stéphanie Corgnac, Isabelle Damei, Laetitia Grynszpan, Gwendoline Gros, Vincent de Montpréville, Fathia Mami-Chouaib 12/01/21 Nature Communications
Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition (Nature Reviews Molecular Cell Biology, (2020), 21, 6, (341-352), 10.1038/s41580-020-0237-9) Pierre Savagner 12/01/21 Nature Reviews Molecular Cell Biology
When Immunity Kills: The Lessons of SARS-CoV-2 Outbreak Yassine Taoufik, Stéphanie Corgnac, Antoine Durrbach, Fathia Mami-Chouaib 09/24/21 Frontiers in Immunology
Nanomedicine-based cancer immunotherapy: recent trends and future perspectives Salem Chouaib 09/01/21 Cancer Gene Therapy
Investigation of new biomarkers of kidney injury in renal transplant recipients undergoing graft biopsy Antoine Durrbach 09/01/21 Clinical Transplantation
Prolonged in-hospital stay and higher mortality after Covid-19 among patients with non-Hodgkin lymphoma treated with B-cell depleting immunotherapy Yassine Taoufik 08/01/21 American Journal of Hematology
The most common vhl point mutation r167q in hereditary vhl disease interferes with cell plasticity regulation Stéphanie Buart, Stéphane Terry, Abdérémane Abdou, Julien Adam, Jérôme Thiery, Pierre Savagner, Salem Chouaib 08/01/21 Cancers

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)