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Immunologie anti-tumorale et immunothérapie des cancers

Laboratory presentation

The laboratory of cancer immunology and immunotherapy against cancer has 2 major research themes. The first is the immunology of tumors and immunotherapy against cancer and the second is the role of mRNA translation in the antigen presentation. These topics include studies on the intestinal microbiota and tumors inflammation, immunotherapy customized by monoclonal antibodies or on the cross-presentation to MHC class I on antigenic peptides. This research focuses on a better understanding of immunology in cancer patients and to improve personalized treatments to better fight this disease. This work in partnership with numerous industrial partners has already enabled the implementation of 6 patents.

The 20 latest publications

Title Authors Publication date Source
Response to contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells Camille Blériot, Florent Ginhoux 07/12/22 Immunity
Infection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19 Pierre Moine, Simon Bessis, Mathieu Godement, Djillali Annane 07/01/22 Cellular and Molecular Life Sciences
Immune contexture of paediatric cancers Aurelien Marabelle 07/01/22 European Journal of Cancer
Health-related quality of life in patients treated with pembrolizumab for microsatellite instability–high/mismatch repair–deficient advanced solid tumours: Results from the KEYNOTE-158 study Aurelien Marabelle 07/01/22 European Journal of Cancer
BCG therapy downregulates HLA-I on malignant cells to subvert antitumor immune responses in bladder cancer Julien Adam 06/15/22 Journal of Clinical Investigation
Dynamics of circulating calprotectin accurately predict the outcome of moderate COVID-19 patients Gérôme Jules-Clément, Sarobidy Rapeteramana 06/01/22 EBioMedicine
Antibiotic Exposure and Immune Checkpoint Inhibitors in Patients With NSCLC: The Backbone Matters Lisa Derosa 06/01/22 Journal of Thoracic Oncology
A subpopulation of hepatic macrophages involved in metabolism regulation Camille Blériot, Florent Ginhoux 06/01/22 Medecine/sciences
Efficacy and safety of larotrectinib in TRK fusion-positive primary central nervous system tumors Birgit Geoerger 06/01/22 Neuro-Oncology
Boosting the immunotherapy response by nutritional interventions Laurence Zitvogel 06/01/22 Journal of Clinical Investigation
Genomic Analysis of Waterpipe Smoke-Induced Lung Tumor Autophagy and Plasticity Salem Chouaib 06/01/22 International Journal of Molecular Sciences
Clinical, pathologic, and molecular features of inflammatory myofibroblastic tumors in children and adolescents Veronique Minard-Colin 05/01/22 Pediatric Blood and Cancer
Cobimetinib in Pediatric and Young Adult Patients with Relapsed or Refractory Solid Tumors (iMATRIX-cobi): A Multicenter, Phase I/II Study Birgit Geoerger 05/01/22 Targeted Oncology
Pembrolizumab for previously treated advanced anal squamous cell carcinoma: results from the non-randomised, multicohort, multicentre, phase 2 KEYNOTE-158 study Aurelien Marabelle 05/01/22 The Lancet Gastroenterology and Hepatology
The European MAPPYACTS Trial: Precision Medicine Program in Pediatric and Adolescent Patients with Recurrent Malignancies Ludovic Lacroix, Sophie Cotteret, Jean Yves Scoazec 05/01/22 Cancer Discovery
Vaccine Therapy in Non-Small Cell Lung Cancer Stéphanie Corgnac 05/01/22 Vaccines
Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition Jean Paul Thiery, Salem Chouaib, Stéphane Terry 04/27/22 Frontiers in Immunology
Cancer stem-like cells evade CD8<sup>+</sup>CD103<sup>+</sup> tumor-resident memory T (T<inf>RM</inf>) lymphocytes by initiating an epithelial-to-mesenchymal transition program in a human lung tumor model Aziza Caidi, Marc Deloger 04/13/22 Journal for ImmunoTherapy of Cancer
Cross-reactivity between microbial and tumor antigens Laurence Zitvogel 04/01/22 Current Opinion in Immunology
Immunogenic cell stress and death Laurence Zitvogel 04/01/22 Nature Immunology

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)