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Hypertension pulmonaire : physiopathologie et innovation thérapeutique

Laboratory presentation

Inserm UMR-S 999 is a major actor in national and international translational research on pulmonary hypertension, leading to major physiopathological, medical and surgical advances. It is subdivided into two research, physiopathological and clinical teams composed of researchers, clinicians and surgeons who have been working in synergy since 2010. Thanks to a national register of patients (National Reference Center for Severe Pulmonary Hypertension), a biobank of cells and tissues, and an internationally recognized expertise, the two teams are studying the mechanisms of pulmonary vascular remodeling and associated heart disease in humans, rodents and large animals.

The 20 latest publications

Title Authors Publication date Source
Smooth muscle Rac1 contributes to pulmonary hypertension Christophe Guignabert 07/01/22 British Journal of Pharmacology
Oscillation Transmission of Modern High-Frequency Neonatal Ventilators Under Different Lung Mechanics Conditions Daniele De Luca 07/01/22 Respiratory Care
Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension Marc Humbert, David Montani, Barbara Girerd, Olivier Sitbon 06/15/22 American Journal of Respiratory and Critical Care Medicine
HFp<sup>2</sup>EF: heart failure with pulmonary dysfunction and preserved ejection fraction? Marc Humbert 06/14/22 European Heart Journal
Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study J. L. Teboul 06/01/22 Intensive Care Medicine
Oral anticoagulants (NOAC and VKA) in chronic thromboembolic pulmonary hypertension Marc Humbert, Gerald Simonneau 06/01/22 Journal of Heart and Lung Transplantation
Early echocardiography by treating physicians and outcome in the critically ill: An ancillary study from the prospective multicenter trial FROG-ICU X. Monnet 06/01/22 Journal of Critical Care
Recommandations des sociétés d'experts sur la prise en charge du pneumothorax spontané primaire: Recommendations from expert societies on the management of primary spontaneous pneumothorax A. Beauvais, Elise Noel-Savina, G. Mangiapan, Jonathan Messika, S. Jounneau, Thibaut J. Desmettre 06/01/22 Revue des Maladies Respiratoires Actualites
To be or not to be… treated with initial combination therapy, that is the (PAH) question Athénaïs Boucly, Marc Humbert, Olivier Sitbon 06/01/22 European Respiratory Journal
The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis T. Pham 05/01/22 Intensive Care Medicine
Extracorporeal Membrane Oxygenation for Respiratory Failure Related to COVID-19: A Nationwide Cohort Study Julien Guihaire 05/01/22 Anesthesiology
Using the Plasma Proteome for Risk Stratifying Patients with Pulmonary Arterial Hypertension Barbara Girerd, David Montani, Athénaïs Boucly, Olivier Sitbon, Marc Humbert 05/01/22 American Journal of Respiratory and Critical Care Medicine
C-reactive protein predicts early clinical outcomes and long-term mortality after left ventricular assisted device Rui Shi 05/01/22 International Journal of Artificial Organs
New Mutations and Pathogenesis of Pulmonary Hypertension: Progress and Puzzles in Disease Pathogenesis Christophe Guignabert 04/29/22 Circulation Research
Platelet-Derived Growth Factor Receptor Type α Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension L. Tu, Raphaël Thuillet, Marc Humbert, Christophe Guignabert 04/05/22 Journal of the American Heart Association
Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort Marc Humbert, Peter Dorfmüller, Olaf Mercier, Christophe Guignabert 04/01/22 Journal of Heart and Lung Transplantation
Determinants of survival after lung transplantation in telomerase-related gene mutation carriers: A retrospective cohort Jérôme Le Pavec 04/01/22 American Journal of Transplantation
Respiratory symptoms and radiological findings in post-acute COVID-19 syndrome Etienne Marie Jutant, Antoine Beurnier, Xavier Jaïs, Athénaïs Boucly, Sophie Bulifon, Mitja Jevnikar, Jérémie Pichon, Anne Roche, Andrei Seferian, Olivier Sitbon, Marc Humbert, Laurent Savale, David Montani 04/01/22 ERJ Open Research
Meta-Analysis of Lung Ultrasound Scores for Early Prediction of Bronchopulmonary Dysplasia Daniele De Luca 04/01/22 Annals of the American Thoracic Society
Role of Ion Channel Remodeling in Endothelial Dysfunction Induced by Pulmonary Arterial Hypertension Hélène Le Ribeuz, Fabrice Antigny 04/01/22 Biomolecules

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)