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Hémostase, inflammation, thrombose

Laboratory presentation

The Hemostasis, Inflammation and Thrombosis Unit is interested in the platelets biology and associated cardiovascular diseases. This well-defined research perimeters, hospital involvement and the I2B's technical resources at the Bicêtre hospital site offer high international visibility. It brings together two synergistic teams, each made up of biologists and clinicians. Team 1 studies the physiology of haemostasis and its pathological aspects, focusing particularly on haemorrhagic pathologies, such as hemophilia, Willebrand disease, filaminopathies, gray platelet syndrome or Scott\'s syndrome. In addition, this team is in charge of the nanobodies synthesis, new tools created from antibodies for the study of biological phenomena and the treatment of pathologies. Team 2 is interested in the communication between inflammation and hemostasis and its implications in vascular pathologies as well as in platelet and endothelial calcium homeostasis. Some projects are of a fundamental nature while another aspect aims to develop new therapies.

The 20 latest publications

Title Authors Publication date Source
Antithrombotic potential of a single-domain antibody enhancing the activated protein C-cofactor activity of protein S Josepha C. Sedzro, Frédéric Adam, Claire Auditeau, Elsa Bianchini, Allan De Carvalho, Ivan Peyron, Sadyo Daramé, Olivier D. Christophe, Peter J. Lenting, Cecile V. Denis, Delphine Borgel, François Saller 07/01/22 Journal of Thrombosis and Haemostasis
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies Marc Vasse 05/24/22 Proceedings of the National Academy of Sciences of the United States of America
Towards novel treatment options in von Willebrand disease Peter J. Lenting, Claire Kizlik-Manson, Caterina Casari 05/01/22 Haemophilia
How can the design of therapeutic SERPINs be improved? Elsa Bianchini, Claire Auditeau, Delphine Borgel 05/01/22 Journal of Thrombosis and Haemostasis
The immunosuppressant drug Cyclosporin A aggravates irradiation effects in endothelial cells Kathia Beddek, Régis Bobe 04/30/22 Biochemical and Biophysical Research Communications
How I manage pregnancy in women with Glanzmann thrombasthenia Roseline d'Oiron 04/28/22 Blood
In vitro recovery of FIX clotting activity as a marker of highly functional hepatocytes in a hemophilia B iPSC model Olivier D. Christophe 04/01/22 Hepatology
The Proteolytic Inactivation of Protein Z-Dependent Protease Inhibitor by Neutrophil Elastase Might Promote the Procoagulant Activity of Neutrophil Extracellular Traps in Sepsis Elsa Bianchini, Mahita Razanakolona, Allan De Carvalho, Cecile V. Denis, Marc Vasse, Delphine Borgel 04/01/22 Thrombosis and Haemostasis
Emicizumab does not interfere with the activated clotting time Maximilien Desvages, Roseline d'Oiron, Delphine Borgel, Dominique Lasne 03/01/22 Haemophilia
Osteoprotegerin modulates platelet adhesion to von Willebrand factor during release from endothelial cells Nikolett Wohner, Vincent Muczynski, Philip G. de Groot, Peter J. Lenting 03/01/22 Journal of Thrombosis and Haemostasis
Gain-of-Function Variant pPro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics Cecile V. Denis 02/01/22 Thrombosis and Haemostasis
The VWF/LRP4/αVβ3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells Vincent Muczynski, Paulette Legendre, Marc Damien Lourenco-Rodrigues, Olivier D. Christophe, Peter J. Lenting, Cecile V. Denis 02/01/22 Cardiovascular Research
TaSER: Combining forces to stop the clot Cecile V. Denis, Peter J. Lenting 02/01/22 Journal of Thrombosis and Haemostasis
Microlyse: a thrombolytic agent that targets VWF for clearance of microvascular thrombosis Peter J. Lenting 01/27/22 Blood
Letter comments on: Efficacy and safety of BNT162b2 vaccination in solid cancer patients receiving anti-cancer therapy - A single-centre prospective study: Interaction between lymphopenia and anti-SARS-CoV-2 antibodies after two injections of the Pfizer-BioNTech vaccine in patients with cancers treated by chemotherapy or immunotherapy Marc Vasse 01/01/22 European Journal of Cancer
Long-term safety and efficacy of lentiviral hematopoietic stem/progenitor cell gene therapy for Wiskott–Aldrich syndrome Anne Galy 01/01/22 Nature Medicine
Impact of COVID-19 on thrombus composition and response to thrombolysis: Insights from a monocentric cohort population of COVID-19 patients with acute ischemic stroke Marc Vasse 01/01/22 Journal of Thrombosis and Haemostasis
A compact integrated microfluidic oxygenator with high gas exchange efficiency and compatibility for long-lasting endothelialization Caterina Casari, Cecile V. Denis, Peter J. Lenting 12/21/21 Lab on a Chip - Miniaturisation for Chemistry and Biology
GFHT proposals on the practical use of argatroban — With specifics regarding vaccine-induced immune thrombotic thrombocytopaenia (VITT) Dominique Lasne 12/01/21 Anaesthesia, Critical Care & Pain Medicine
Cultured platelets from micro to macro, how to move towards an efficient production? Alexandre Kauskot, Cecile V. Denis 12/01/21 Bulletin de l'Academie Nationale de Medecine

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)