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Chimie et modélisation pour la biologie du cancer

Laboratory presentation

The central activity of the CMIB unit is to develop small molecules to investigate and control the biological activities of the main targets involved in cancer. These are essentially non-B (quadruplex) nucleic acid structures and kinases. IR-photoexcitable probes designed for both subcellular monitoring and targeted photo-aging are also important research axes. The drug and probe design activity is supported by the molecular modeling approach and Multimodal imaging (TEM, NanoSIMS, MRI). These approaches include the development of image processing and analysis methods as well as the design of software tools and protocols for biology imaging. The CMIB unit hosts the Institut Curie-CNRS library, 9000 chemical compounds, preclinical MRI imaging and chemical imaging platforms.

The 20 latest publications

Title Authors Publication date Source
Effect of peripherical groups on the two-photon brightness of (E)-3-benzyl-6-bromo-2-styryl-3H-imidazo[4,5-b]pyridine derivatives Sandrine Piguel 07/15/22 Journal of Molecular Liquids
Photoactivatable V-Shaped Bifunctional Quinone Methide Precursors as a New Class of Selective G-quadruplex Alkylating Agents Sophie Bombard, Daniela Verga 06/21/22 Chemistry - A European Journal
Use of Dental Defects Associated with Low-Dose di(2-Ethylhexyl)Phthalate as an Early Marker of Exposure to Environmental Toxicants Nicolas Roubier, E. Vennat 06/01/22 Environmental Health Perspectives
The Long Non-Coding RNA HOXA-AS2 Promotes Proliferation of Glioma Stem Cells and Modulates Their Inflammation Pathway Mainly through Post-Transcriptional Regulation Pierre Verrelle 05/01/22 International Journal of Molecular Sciences
Assessment of presumed small-molecule ligands of telomeric i-DNA by biolayer interferometry (BLI) Joseph Boissieras, Anton Granzhan 03/30/22 Chemical Communications
G-quadruplexes in helminth parasites Yu Luo, Daniela Verga 03/21/22 Nucleic Acids Research
Cellular Detection of a Mitochondria Targeted Brominated Vinyl Triphenylamine Optical Probe (TP−Br) by X-Ray Fluorescence Microscopy Sounderya Nagarajan, Florent Poyer, Laura Fourmois, Delphine Naud-Martin, Florence Mahuteau-Betzer 03/10/22 Chemistry - A European Journal
On the Road Toward More Efficient Biocompatible Two-Photon Excitable Fluorophores Marie Auvray, Delphine Naud-Martin, Matthieu Poulain, Margaux Bossuat, Florence Mahuteau-Betzer 03/07/22 Chemistry - A European Journal
Harnessing an emissive guanine surrogate to design small-molecule fluorescent chemosensors of O<sup>6</sup>-methylguanine-DNA-methyltransferase (MGMT) Alexandra Fillion, Jaime Franco Pinto, Anton Granzhan 03/07/22 Organic and Biomolecular Chemistry
Two-photon brightness of highly fluorescent imidazopyridine derivatives: Two-photon and ultrafast transient absorption studies Sandrine Piguel 02/15/22 Journal of Molecular Liquids
Synthesis and antiproliferative activity of 6BrCaQ-TPP conjugates for targeting the mitochondrial heat shock protein TRAP1 Clelia Mathieu, Elias Fattal, Juliette Vergnaud-Gauduchon 02/05/22 European Journal of Medicinal Chemistry
Influence of electron-withdrawing groups in two-photon absorption of imidazopyridines derivatives Sandrine Piguel 02/01/22 Dyes and Pigments
Protein Dimerization via Tyr Residues: Highlight of a Slow Process with Co‐Existence of Numerous Intermediates and Final Products Patricia Duchambon 02/01/22 International Journal of Molecular Sciences
High-Relaxivity Molecular MRI Contrast Agent to Target Gb3-Expressing Cancer Cells Rose Marie Dubuisson 01/19/22 Bioconjugate Chemistry
Convergent and Practical Synthesis of Fluorescent Triphenylamine Derivatives and Their Localization in Living Cells Marie Auvray, Florence Mahuteau-Betzer 01/17/22 European Journal of Organic Chemistry
Acridine–O<sup>6</sup>-benzylguanine hybrids: Synthesis, DNA binding, MGMT inhibition and antiproliferative activity Jaime Franco Pinto, Alexandra Fillion, Patricia Duchambon, Sophie Bombard, Anton Granzhan 01/05/22 European Journal of Medicinal Chemistry
Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening Jaime Franco 01/01/22 Journal of Enzyme Inhibition and Medicinal Chemistry
The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds Claire Beauvineau 01/01/22 DMM Disease Models and Mechanisms
BrdU immuno-tagged G-quadruplex ligands: a new ligand-guided immunofluorescence approach for tracking G-quadruplexes in cells Thibaut Masson, Corinne Landras Guetta, Eugénie Laigre, Anne Cucchiarini, Patricia Duchambon, Mare Paule Teulade-Fichou, Daniela Verga 12/16/21 Nucleic Acids Research
Differential normal skin transcriptomic response in total body irradiated mice exposed to scattered versus scanned proton beams Frédérique Megnin-Chanet 12/01/21 Scientific Reports

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)