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Biomolécules : conception, isolement, synthèse

Laboratory presentation

The CNRS BioCIS UMR (Biomolecules: Design, Isolation, Synthesis) is a major player in academic research within the Pharmacy UFR (Paris-Saclay University). It has solid expertise in the field of biologically active natural substances, the development of synthesis methodologies and the rational design of new chemical entities (NECs) for therapeutic purposes. Our research efforts in therapeutic innovation focus primarily on neurodegenerative diseases (eg, synucleinopathies, tauopathies) and rare diseases (PAH, epilepsies), anti-infectious, antiparasitic and anti-tumor agents (eg, immuno-oncology, immunoconjugates). The scientific objective is the search for bioactive NECs in the aforementioned fields. With the establishment of a screening platform (CIBLOT) and the possession of a chemical library (approximately 2000 molecules), the scientific expertise of BioCIS is recognized in the fields of natural and synthetic substances. Our partnership approach with biotechnology companies or national and international pharmaceutical groups on eminently topical research projects and our ability to develop our activity at the chemistry-biology interface (filing of patents) clearly illustrate the successes achieved by BioCIS in the field of therapeutic innovation.

The 20 latest publications

Title Authors Publication date Source
Effect of peripherical groups on the two-photon brightness of (E)-3-benzyl-6-bromo-2-styryl-3H-imidazo[4,5-b]pyridine derivatives Sandrine Piguel 07/15/22 Journal of Molecular Liquids
A one-pot synthesis and X-Ray structural characterization of new highly substituted-allyl carbamates Benoit Crousse 06/15/22 Journal of Molecular Structure
Recent Developments in the Photochemical Synthesis of Functionalized Imidazopyridines Christine Tran, Abdallah Hamze 06/01/22 Molecules
Combined LC-MS/MS and Molecular Networking Approach Reveals Antioxidant and Antimicrobial Compounds from Erismadelphus exsul Bark Mehdi A. Beniddir 06/01/22 Plants
Synthesis, antiviral and antitumor activities investigations of a series of Ribavirin C-nucleoside analogue prodrugs Nazarii Sabat, Abdelhakim Ouarti, Florian Gallier, Nadège Lubin-Germain, Jacques Uziel 05/01/22 Bioorganic Chemistry
Targeting chalcone binding sites in living Leishmania using a reversible fluorogenic benzochalcone probe Sébastien Pomel, Philippe M. Loiseau 05/01/22 Biomedicine and Pharmacotherapy
Antioxidant Quercetin 3-O-Glycosylated Plant Flavonols Contribute to Transthyretin Stabilization Nicolo Tonali 05/01/22 Crystals
Formulation of Amphotericin B in PEGylated Liposomes for Improved Treatment of Cutaneous Leishmaniasis by Parenteral and Oral Routes Philippe M. Loiseau 05/01/22 Pharmaceutics
Synthesis of Dihydro-5H-Benzo[c]-Fluorenes, Dihydroindeno[c]-Chromenes and Thiochromenes via Intramolecular Cyclization and their Effect on Human Leukemia Cells Jun Yan, Christine Tran, Olivier Provot, Abdallah Hamze 04/26/22 Advanced Synthesis and Catalysis
Dereplication of Acetogenins from Annona muricata by Combining Tandem Mass Spectrometry after Lithium and Copper Postcolumn Cationization and Molecular Networks Pierre Champy 04/06/22 Journal of the American Society for Mass Spectrometry
Label-free LC-HRMS-based enzymatic activity assay for the detection of DDC, MAO and COMT inhibitors Abha Harfouche, Karine Leblanc, Ghislain Heslaut, Bruno Figadère, Alexandre Maciuk 04/01/22 Journal of Pharmaceutical and Biomedical Analysis
The Potential of 2-Substituted Quinolines as Antileishmanial Drug Candidates Philippe M. Loiseau, Sébastien Pomel, Rémy Durand, Bruno Figadère 04/01/22 Molecules
Biological Investigation of a Water-Soluble Isoginkgetin-Phosphate Analogue, Targeting the Spliceosome with in Vivo Antitumor Activity Boris Letribot, Dolor Renko, Mouad Alami, Samir Messaoudi 03/24/22 Journal of Medicinal Chemistry
High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators Abdallah Hamze, Olivier Provot 03/18/22 ACS Chemical Biology
Sonogashira cross-coupling as a key step in the synthesis of new glycoporphyrins Morgane de Robichon, Angélique Ferry 03/15/22 Organic Chemistry Frontiers
Azoliums and Ag(I)-N-Heterocyclic Carbene Thioglycosides: Synthesis, Reactivity and Bioactivity Dmytro Ryzhakov, Franck Le Bideau, Riyadh Ahmed Atto Al-Shuaeeb, Mouad Alami, Samir Messaoudi 03/07/22 European Journal of Organic Chemistry
Direct Access to Fluorinated Sulfonylhydrazides and Study of Their Reactivity in Thiolation Reaction on Indoles Tingting Cao, Benoit Crousse 03/01/22 Helvetica Chimica Acta
Going ballistic: Leishmania nuclear subversion of host cell plasticity Maria Gutiérrez-Sanchez 03/01/22 Trends in Parasitology
Recent Progress on the Mild Deprotection of Dithioketals, Dithioacetals, and Oxathiolanes Jun Yan, Abdallah Hamze, Olivier Provot 02/18/22 European Journal of Organic Chemistry
Two-photon brightness of highly fluorescent imidazopyridine derivatives: Two-photon and ultrafast transient absorption studies Sandrine Piguel 02/15/22 Journal of Molecular Liquids

Nombre de publications du laboratoire par domaine scientifique

Chaque publication du laboratoire peut être rangée dans une ou plusieurs disciplines scientifiques : la figure ci-dessus présente le nombre de publications du laboratoire pour chaque discipline de la classification ASJC (Elsevier)