The recent advances in cell and developmental biology (including imaging, stem cell biology and systems biology) integrate biological mechanisms at multiple scales, from the level of molecular complexes to the whole organism. These fundamental discoveries will have significant therapeutic benefits, notably in cancer biology and regenerative medicine. The “Gene, Cell, and Development” (GCD) Master course explores molecular, genetic and epigenetic mechanisms from cell to organism. This training provides the concepts and methods to understand the variety of processes controlling cell biology during development, differentiation, and disease.
English is the universal language of modern biology, either within laboratories, institutes and meetings or for written communication. In order for French students to become fluent in scientific English, and to open the course to foreign students, the GCD course will be mostly in English and the scientific articles to present will be in English. An average level of scholar english will be sufficient. Evaluations will be either in French or in English.
The GCD course includes introductory and advanced lectures by Professors and researchers. A variety of digital and online resources will be used during the lectures, tutorials and workshops as pedagogical tools (films, simulations etc...).
The GCD course includes an international colloquium, sponsored by Institut Curie, a world-class French cancer research center, in association with Université Paris Sud. For a week, several national and international speakers are invited to present their research around the themes of development and cancer. These seminars are open to GCD master students, students from other masters, Ph. D., and researchers. It is a unique opportunity for the GCD master students to meet researchers in their fields of interest in an informal setting.
The second year of Masters is the introduction to scientific research: to develop their personal thinking on the lectures and the recent scientific literature, the students will conduct personal work under the supervision of a scientific mentor. The students will present a bibliographic seminar, chosen on the subject developped in one of the lectures. During such tutored projects, the students develop their communication skills, and benefit from the expertise of academics or researchers recognized in their field.
Finally, the GCD course includes a reinforced practical training. A two-weeks practical course is organized in association with scientific laboratories and platforms. This course allows small groups of students to discover current laboratory techniques, from the basics to some of the latest methodologies, notably using advanced imaging. Students will learn to communicate and share of their results, analyze their experimental results and critically discuss them, under the form of a short research-like article. Students thus get trained into the rigorous criteria of scientific method. The practical training also includes a six months internship during which the student develops his own scientific project within a host research laboratory.
Modalités de contrôle des connaissances associées aux unités d'enseignement des S1 et S2
Accédez au détail des répartitions horaires Cours/TP/TD
- S3 - Semestre 3 P2
Matières Ects Cours TD TP Dynamique et communication cellulaire - UPSud 3 21h 10h - Approche génétique et cellulaire du développement - UPSud 3 21h 10h - Bioimagerie : traitement et analyse des images biologiques digitales 3 10h - 15h ARN non-codants et épigénétique - UPSud 3 20h 5h - Neuro-développement et cellules souches - UPSud 3 10h - 15h Développement et oncogénèse, aspects théoriques 3 21h 10h - Développement et oncogénèse, aspects pratiques 6 6h - 64h Analyse bibliographique et Projet scientifique 6 - - -
- S4 - Semestre 4 P2
Matières Ects Cours TD TP Stage en laboratoire P2 30 - 50h -
Teaching will mainly be located on Université Paris-Sud campus. The Institut Curie International Colloquium will take place at Institut Curie, on Orsay Campus. Practical courses will take place in several locations, including Université Paris-Sud campus.
The main job prospects after this second year of masters will be in fundamental and applied research in France or abroad. This can be achieved mostly by pursuing a Ph.D. thesis, but a few engineer level positions are open after a master thesis. Positions will be found in major academic research institutes, affiliated to University, CNRS, INSERM, INRA, or CEA. The Ph.D. thesis will open the path to an academic research career. Aside academia, other job openings will be found in private companies, as this master degree provides background to become project manager in research and development, clinical research investigator or research engineer. This training is also recommended for clinicians and medical students willing to acquire a fundamental knowledge in cell and developmental biology and pursue clinical research.
The students following the GCD master will work for six months in a host research laboratory, to develop a personal research project, under the close supervision of a mentor. This project will be prepared beforehand, during a specific Teaching Unit, to explore the litterature of the proposed subject and to prepare the outline of the final scientific report. At the end of the research, a written manuscript and and oral presentation (in French or English) will be evaluated by the master committee. In addition to being an immersion into laboratory research, this training potentially sets the basis for a longer Ph.D. project.
The “Gene, Cell, and Development” Master course is an advanced course on cell biology during development, differentiation, and disease. A series of lectures, practical courses and personal research will enable the students to understand the recent developments and the current challenges of research around those themes. Science and medical students will thus acquire theoretical knowledge and practical skills essential for them to understand the research topics of their future host laboratories, wherever they will pursue academic, applied or clinical research.
The Gene Cell and Development Master course is open to international students, provided that they have acquired a level equivalent to the first year of Masters.
Les modalités d'examen de la candidature sont les suivantes : Examen de dossier à déposer sur le site web de l'UPSaclay et éventuellement entretien
Mandatory supporting documents
Additional supporting documents
Many laboratories will be available to host the practical training for the GCD master students. This master course is closely linked to many laboratories developing research in cell biology, developmental biology, stem cell research, cancer research in the Paris Saclay Campus and in other French Campuses. Students will find a variety of approaches to explore normal and pathological cell biology, as depicted on the websites of each institute. A list of the main Paris Saclay host laboratories is provided below. I2BC (Institut de Biologie Intégrative de la Cellule) – Gif-sur-Yvette Institut Curie - Orsay IPS2 (Institut of Plant Sciences Paris-Saclay) Orsay IDEEV (Institut Diversité, Ecologie et Evolution du Vivant) NeuroPSI (Neuroscience Paris Saclay Institute)- Gif sur Yvette – Orsay - Saclay I2C (Infection et Inflammation Chronique) INSERM – UVSQ, Montigny le Bretonneux Handicap Neuromusculaire INSERM – UVSQ, Montigny le Bretonneux Laboratoire Gamète, Implantation, Gestation UVSQ, Montigny le Bretonneux Laboratoire de Génétique et Biologie Cellulaire UVSQ, Montigny le Bretonneux Institut Micalis INRA de Jouy-en-Josas BDR (Biologie du Développement et Reproduction) INRA, Jouy-en-Josas GABI (Génétique Animale et Biologie Intégrative) INRA, Jouy-en-Josas Institut des cellules souches pour le traitement et l'étude des maladies monogéniques (I-Stem), INSERM-AFM,Evry Centre National de Génotypage (CNG), CEA Evry, Genoscope, CEA Evry Généthon, AFM-Téléthon, Evry Laboratoire de Recherche Européen pour la Polyarthrite rhumatoïde (GenHotel), UEVE Laboratoires de Biologie de la Genopole d’Evry LBPA (Laboratoire de biologie et de pharmacologie appliquée) – ENS Cachan Institut Gustave Roussy – Villejuif.